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Nutlin-3

Catalog #: 3984
8 Citations Datasheet
Catalog # Availability Size / Price Qty
3984/10
Nutlin-3 | CAS No. 548472-68-0 | p53 Inhibitors
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Description: MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Technical Data

M.Wt:
581.49
Formula:
C30H30Cl2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
548472-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from F. Hoffmann-La Roche Ltd.

Background References

  1. Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia.
    Seipel K, Marques M, Bozzini M, Meinken C, Mueller B, Pabst T
    Clin Cancer Res, 2016;22(3):746-56.
  2. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
    M Periyasamy, AK Singh, C Gemma, C Kranjec, R Farzan, DA Leach, N Navaratnam, HL Pálinkás, BG Vértessy, TR Fenton, J Doorbar, F Fuller-Pac, DW Meek, RC Coombes, L Buluwela, S Ali
    Nucleic Acids Res., 2017;0(0):.
  3. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
    Vassilev et al.
    Science, 2004;303:844

Product Datasheets

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Citations for Nutlin-3

The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:

8 Citations: Showing 1 - 8

  1. Comparison of Different Clinical Chemotherapeutical Agents' Toxicity and Cell Response on Mesenchymal Stem Cells and Cancer Cells.
    Authors: Gergely Et al.
    Cells  2022;11
  2. Replication stress promotes cell elimination by extrusion.
    Authors: Daniel P Et al.
    Nature  2021;593:591-596
  3. Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
    Authors: Peter Et al.
    Life Sci Alliance  2020;3
  4. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
    Authors: Keeva Et al.
    Nat Chem Biol  2018;14:118-125
  5. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
    Authors: Norlin Et al.
    Development  2018;145
  6. A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
    Authors: Yang Et al.
    Nat Commun  2016;7:13599
  7. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
    Authors: Bussey Et al.
    J Zhejiang Univ Sci B  2016;5:1
  8. Small molecule induced reactivation of mutant p53 in cancer cells.
    Authors: Alan R Et al.
    Nucleic Acids Res  2013;41:6034-44

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