NSC 668036
Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
Purity: ≥98%
Biological Activity
NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of a specific inhibitor of the dishevelled PDZ domain.
Shan et al.
Biochemistry, 2005;44:15495 -
Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process.
Wang et al.
Exp.Cell Res., 2015;331:115
Product Datasheets
Citations for NSC 668036
The citations listed below are publications that use Tocris products. Selected citations for NSC 668036 include:
3 Citations: Showing 1 - 3
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The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation.
Authors: Carr Et al.
J.Biol.Chem. 2023;299:104645
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Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells.
Authors: Ming Et al.
Elife 2022;11
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Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells.
Authors: Carlos Et al.
Front Oncol 2021;11:729228
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