NSC 636819

Catalog #: 5287 1 Review Datasheet

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5287/50

NSC 636819 | CAS No. 1618672-71-1 | Histone Demethylase Inhibitors

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Description: KDM4A/KDM4B inhibitor

Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene

Purity: ≥98%

View All Products for Histone Demethylase Inhibitors

Product Details

Reviews (1)

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data

M.Wt:

510.15

Formula:

C₂₂H₁₂Cl₄N₂O₄

Solubility:

Soluble to 10 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1618672-71-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.
Chu et al.
J.Med.Chem., 2014;57:5975

Product Datasheets

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SDS

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Reviews for NSC 636819

Average Rating: 5 (Based on 1 Review)

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Good Product.

By Anonymous on 08/20/2018

Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.

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