NS 3861

Catalog #: 4831 Datasheet

Catalog #	Availability	Size / Price	Qty
4831/5
4831/25

NS 3861 | CAS No. 216853-60-0 | Additional Nicotinic Receptor Agonists

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Description: α3β2 full agonist; also α3β4 partial agonist

Chemical Name: 3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NS 3861 is a α3β2 full agonist (EC₅₀ = 1.6 μM). Also α3β4 partial agonist (EC₅₀ = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (K_i values are 0.62, 7.8, 25 and 55 nM respectively).

Technical Data

M.Wt:

400.29

Formula:

C₁₂H₁₄BrNS.C₄H₄O₄

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

216853-60-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.
Harpsøe et al.
J.Biol.Chem., 2013;288:2559

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