Home / Guanylyl Cyclase Inhibitors / NS 2028

NS 2028

Catalog #: 4517
1 Citation Datasheet
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4517/50
NS 2028 | CAS No. 204326-43-2 | Guanylyl Cyclase Inhibitors
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Description: Potent soluble guanylyl cyclase (sGC) inhibitor

Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Technical Data

M.Wt:
269.05
Formula:
C9H5BrN2O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
204326-43-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Protective role of cellular prion protein against TNF?-mediated inflammation through TACE ?-secretase
    J Ezpeleta, F Boudet-Dev, M Pietri, A Baudry, V Baudouin, A Alleaume-B, N Dagoneau, O Kellermann, JM Launay, B Schneider
    Sci Rep, 2017;7(1):7671.
  2. Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.
    von Wantoch Rekowski et al.
    Bioorg.Med.Chem., 2010;18:1288
  3. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.
    Morbidelli et al.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2010;298:R824
  4. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
    Olesen et al.
    Br.J.Pharmacol., 1998;123:299

Product Datasheets

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Citation for NS 2028

The citations listed below are publications that use Tocris products. Selected citations for NS 2028 include:

1 Citation: Showing 1 - 1

  1. 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase.
    Authors: Ping Et al.
    J Biol Chem  2019;294:15577-15592

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