Nocodazole
Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester
Purity: ≥95%
Biological Activity
Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses
L Guillaud, D Dimitrov, T Takahashi
Elife, 2017;6(0):. -
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
Mol Pain, 2014;10(0):45. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.
Lin et al.
Elife, 2014;3:e04766 -
Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.
Webb et al.
Int.J.Biochem.Cell Biol., 2004;36:2541 -
Methods in mammalian autophagy research.
Mizushima et al.
Cell, 2010;140:313 -
Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.
Vasquez et al.
Mol.Biol.Cell, 1997;8:973
Product Datasheets
Citations for Nocodazole
The citations listed below are publications that use Tocris products. Selected citations for Nocodazole include:
12 Citations: Showing 1 - 10
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Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
Authors: Bernier Et al.
Cell Rep 2019;27:2895
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Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Authors: Paonessa Et al.
Cell Rep 2019;26:582
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Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells.
Authors: Romero Et al.
Nat Commun 2018;9:4010
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Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
Authors: Macheret and Halazonetis
Nature 2018;555:112
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Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.
Authors: Guo Et al.
Front Cell Neurosci 2016;18:202
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Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
Authors: Lin Et al.
Nat Commun 2015;6:18577
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Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells.
Authors: Tauchman Et al.
Nat Cell Biol 2015;6:10036
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Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process.
Authors: Hutchins and Wray
Methods Mol Biol 2014;8:400
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Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Authors: Melemedjian Et al.
Mol Pain 2014;10:45
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LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
Authors: Seese Et al.
J Neurosci 2012;32:7403
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Methods for purification of proteins associated with cellular poly(ADP-ribose) and PARP-specific poly(ADP-ribose).
Authors: Rood Et al.
Anal Biochem 2011;780:153
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Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Authors: Schapitz Et al.
Oncotarget 2010;30:12733
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