NK 252
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity: ≥98%
Biological Activity
NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model.
Shimozono et al.
Mol.Pharmacol., 2013;84:62
Product Datasheets
Citation for NK 252
The citations listed below are publications that use Tocris products. Selected citations for NK 252 include:
1 Citation: Showing 1 - 1
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A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.
Authors: Vladimir Et al.
Redox Biol 2021;48:102186
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