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Nimodipine

Catalog #: 0600
31 Citations Datasheet
Catalog # Availability Size / Price Qty
0600/100
Nimodipine | CAS No. 66085-59-4 | Cav1.x Channel Blockers
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Description: CaV1.x blocker

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester

Purity: ≥99%

Product Details
Citations (31)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Nimodipine is a L-type Ca2+ channel blocker. Induces autophagy. Nimodipine is modulating pericytes and other inflammation signals like Hypoxia and leukocyte stalling to improve cognitive function in Alzheimer�s disease. Nimodipine reduces pericytes and other inflammation signals like hypoxia and leukocyte stalling and improves cognitive function in Alzheimer's disease model mice.

Technical Data

M.Wt:
418.45
Formula:
C21H26N2O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
66085-59-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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SDS
⚠ WARNING: This product can expose you to chemicals including Nimodipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Nimodipine

The citations listed below are publications that use Tocris products. Selected citations for Nimodipine include:

31 Citations: Showing 1 - 10

  1. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
    Authors: Haeberle Et al.
    Mol Biol Cell  ;3:e1750
  2. Inhibiting Ca2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia.
    Authors: Korte Et al.
    Nat. Neurosci.  2024;
  3. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
    Authors: O'Malley Et al.
    J Neurosci  2020;40:4813
  4. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
    Authors: Doshina Et al.
    Sci Rep  2017;7:370
  5. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  6. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
    Authors: Robinson Et al.
    EMBO J  2015;9:404
  7. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    PLoS One  2015;6:8302
  8. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  9. Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons.
    Authors: Gan and Silverman
    PLoS One  2015;26:1058
  10. Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
    Authors: Pourbadie Et al.
    Front Cell Neurosci  2015;10:e0117555
  11. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds.
    Authors: Schöbel Et al.
    Chem Senses  2014;39:471
  12. Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons.
    Authors: Clemens and Johnston
    J Neurophysiol  2014;111:1369
  13. Causes and consequences of hyperexcitation in central clock neurons.
    Authors: Diekman Et al.
    PLoS Comput Biol  2013;9:e1003196
  14. MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease.
    Authors: Elmer Et al.
    J Neurosci  2013;33:13791
  15. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Br J Pharmacol  2013;33:11206
  16. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
    Authors: Liu Et al.
    J Neurophysiol  2013;110:505
  17. Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses.
    Authors: Schöbel Et al.
    PLoS One  2012;7:e48005
  18. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  19. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
    Authors: Hulme Et al.
    J Neurosci  2012;32:6785
  20. The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  21. Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites.
    Authors: Colgan Et al.
    J Neurosci  2012;32:15737
  22. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Neurosci  2012;31:2937
  23. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol  2011;589:919
  24. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med  2010;16:694
  25. Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  26. Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
    Authors: Grey and Burrell
    J Neurophysiol  2010;103:2737
  27. Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders.
    Authors: McElligott
    Neuropsychopharmacology  2008;33:2313
  28. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
    Authors: Wu Et al.
    J Neurophysiol  2008;100:1897
  29. Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage.
    Authors: Facchinetti Et al.
    Neurobiol Aging  2006;27:218
  30. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
    Authors: Bender Et al.
    J Neurosci  2006;26:4166
  31. Molecular profiling reveals synaptic release machinery in Merkel cells.
    Authors: Haeberle Et al.
    Proc Natl Acad Sci U S A  2004;101:14503

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