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Nifedipine

Catalog #: 1075
37 Citations Datasheet
Catalog # Availability Size / Price Qty
1075/100
Nifedipine | CAS No. 21829-25-4 | Cav1.x Channel Blockers
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Description: CaV1.x blocker

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Purity: ≥98%

Product Details
Citations (37)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Nifedipine is a L-type calcium channel blocker.

Technical Data

M.Wt:
346.34
Formula:
C17H18N2O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
21829-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
    Chen, Meng, Wan, Yehong, Ade, Kristen, Ting, Jonathan, Feng, Guoping, Calakos, Nicole
    J Neurosci, 2011;31(26):9563-73.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

    Nat Commun, 2016;7(0):12961.
  4. Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth.
    Mire E, Mezzera C, Leyva-Diaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, Lopez MJ, Peregrin S, Tessier-Lavigne M, Garel S, Galceran J, Lerma J, Lopez-Bendito G
    Nat. Neurosci., 2012;15(8):1134-43.
  5. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
    Tung S, Hardy A, Wheeler M, Belsham D
    Endocrinology, 2012;153(10):4862-73.
  6. Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifed.
    Stork and Cocks
    Br.J.Pharmacol., 1994;113:1093

Product Datasheets

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SDS
⚠ WARNING: This product can expose you to chemicals including Nifedipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Nifedipine

The citations listed below are publications that use Tocris products. Selected citations for Nifedipine include:

37 Citations: Showing 1 - 10

  1. The Dependence of Urinary Bladder Responses on Extracellular Calcium Varies Between Muscarinic, Histamine, 5-HT (Serotonin), Neurokinin, Prostaglandin, and Angiotensin Receptor Activation
    Authors: Phelps Et al.
    Front Physiol  2022;13:841181
  2. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
    Authors: Lopez Et al.
    Neuron  2022;110:2283
  3. Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
    Authors: Ciappelloni Et al.
    Cell Rep  2019;27:3860
  4. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
    Authors: Florea Et al.
    Oncotarget  2017;8:22876
  5. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  6. Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
    Authors: Mauger Et al.
    Neuron  2016;92:1266
  7. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
    Authors: Hanlon Et al.
    Breast Cancer (Dove Med Press)  2016;8:59
  8. Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
    Authors: Pigott and Garthwaite
    Front Synaptic Neurosci  2016;8:17
  9. Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
    Authors: Kraidith Et al.
    Am J Physiol Endocrinol Metab  2016;311:E214
  10. N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    J Neurosci  2015;8:4
  11. L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
    Authors: Wang and Mattson
    Neurobiol Aging  2014;35:88
  12. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail  2013;33:1741
  13. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  14. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
    Authors: Yang Et al.
    J Neurosci  2012;32:7550
  15. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Mol Brain  2012;32:3992
  16. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  17. Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
    Authors: Kim Et al.
    J Neurophysiol  2012;108:1965
  18. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids  2011;76:845
  19. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    FEMS Immunol Med Microbiol  2011;4:214
  20. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
    Authors: Xu Et al.
    Mol Cells  2011;406:200
  21. Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
    Authors: Kim and Rhim
    Proc Natl Acad Sci U S A  2011;32:289
  22. NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  23. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    Mol Brain  2011;108:12497
  24. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci  2010;2:1
  25. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol  2010;299:C1180
  26. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem  2010;285:6811
  27. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  28. Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
    Authors: Kato Et al.
    J Neurosci  2009;29:11153
  29. Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
    Authors: Ludwar Et al.
    J Neurophysiol  2009;102:1976
  30. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    Biochem Biophys Res Commun  2008;28:10696
  31. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Proc Natl Acad Sci U S A  2008;105:746
  32. Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
    Authors: Villalba Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H1157
  33. Synapse specificity of long-term potentiation breaks down with aging.
    Authors: Ris and Godaux
    Learn Mem  2007;14:185
  34. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Neurosci  2006;47:296
  35. Adaptation to synaptic inactivity in hippocampal neurons.
    Authors: Thiagarajan Et al.
    Neuron  2005;47:725
  36. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
    Authors: Fujino Et al.
    Mol Cell Neurosci  2003;24:538
  37. Nifedipine facilitates neurotransmitter release independently of calcium channels.
    Authors: Hirasawa
    Proc Natl Acad Sci U S A  2003;100:6139

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