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NIBR LTSi

Catalog #: 8175 Datasheet
Catalog # Availability Size / Price Qty
8175/10
8175/50
NIBR LTSi | Other Kinase Inhibitors
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Description: Potent and selective LATS inhibitor; activates YAP signaling

Chemical Name: N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine

Purity: ≥98%

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Biological Activity

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC50 = 1.4 nM). Also activates YAP signaling (EC50 = 1.0 - 2.7 μM). Promotes liver organoid formation (EC50 = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

Technical Data

M.Wt:
308.39
Formula:
C18H20N4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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