NFAT Inhibitor

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
   T Hadi, L Boytard, M Silvestro, D Alebrahim, S Jacob, J Feinstein, K Barone, W Spiro, S Hutchison, R Simon, D Rateri, F Pinet, D Fenyo, M Adelman, KJ Moore, HK Eltzschig, A Daugherty, B Ramkhelawo
   Nat Commun, 2018;9(1):5022.
2. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
   Aramburu et al.
   Science, 1999;285:2129
3. Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells).
   Nagamoto-Combs and Combs
   J.Neurosci., 2010;30:9641
4. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
   Roehrl et al.
   Proc.Natl.Acad.Sci.USA, 2004;101:7554

Product Datasheets