NF 110
Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt
Purity: ≥90%
Biological Activity
NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.87 μM).This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients.
Dhar et al.
Eur.J.Cancer, 2000;36:803 -
Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist.
Kassack et al.
Eur.J.Med.Chem., 2004;39:345 -
The suramin analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic
Hausmann et al.
Mol.Pharmacol., 2006;69:2058 -
Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Su et al.
Sci.Rep., 2020;10:18850
Product Datasheets
Citations for NF 110
The citations listed below are publications that use Tocris products. Selected citations for NF 110 include:
4 Citations: Showing 1 - 4
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Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Authors: Su Et al.
Sci Rep 2020;10:18850
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Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
Authors: Dosch Et al.
Elife 2019;8
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Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus.
Authors: Chandra Et al.
Viruses 2019;11
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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
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