Nemonapride
Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
Purity: ≥99%
Biological Activity
Nemonapride is a highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective binding of YM-09151-2, a new potent neuroleptic, to D2-DArgic receptors.
Terai et al.
Jpn.J.Pharmacol., 1983;33:749 -
[3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes.
Ujike et al.
Neuroreport, 1996;7:1057 -
5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz.
Assie et al.
Eur.J.Pharmacol., 1997;334:141
Product Datasheets
Citation for Nemonapride
The citations listed below are publications that use Tocris products. Selected citations for Nemonapride include:
1 Citation: Showing 1 - 1
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Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay
Authors: Gadgaard & Jensen
Biochem Pharmacol 2020;175
FAQs
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