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NBQX disodium salt

Catalog #: 1044
42 Citations Datasheet
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NBQX disodium salt | CAS No. 479347-86-9 | AMPA Receptor Antagonists
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Description: Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)

Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

Purity: ≥98%

Product Details
Citations (42)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Technical Data

M.Wt:
380.24
Formula:
C12H6N4O6SNa2
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
479347-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novo Nordisk A/S

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits
    Y Li, G Missig, BC Finger, SM Landino, AJ Alexander, E Mokler, J Robbins, Y Manasian, W Kim, KS Kim, CJ McDougle, WA Carlezon, VY Bolshakov
    J. Neurosci., 2018;0(0):.
  3. 5-HT2C receptor knockdown in the amygdala inhibits neuropathic pain related plasticity and behaviors
    Guangchen Ji
    J. Neurosci, 2016;0(0):.
  4. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.
    Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B, Levenes C
    EMBO Rep, 2014;15(1):103-9.
  5. Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase.
    Farar V, Mohr F, Legrand M
    J Neurochem, 2012;122(5):1065-80.
  6. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model.
    Gill et al.
    Brain Res., 1992;580:35
  7. Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.
    Namba et al.
    Brain Res., 1994;638:36
  8. The pharmacology of AMPA receptors and their antagonists.
    Sheardown et al.
    Stroke, 1993;24:146
  9. Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro.
    Zeman and Lodg
    Br.J.Pharmacol., 1992;106:367
  10. Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test
    Yoon et al.
    J.Korean Med.Sci., 2005;20:307

Product Datasheets

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Citations for NBQX disodium salt

The citations listed below are publications that use Tocris products. Selected citations for NBQX disodium salt include:

42 Citations: Showing 1 - 10

  1. Multi-target action of β-alanine protects cerebellar tissue from ischemic damage.
    Authors: Kopach Et al.
    Cell Death Dis  2022;13:747
  2. Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons.
    Authors: Maldonado Et al.
    Curr Biol  2021;31:322
  3. Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
    Authors: Kramer Et al.
    ELife  2020;9
  4. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
    Authors: O'Malley Et al.
    J Neurosci  2020;40:4813
  5. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
    Authors: Evans Et al.
    Cell Rep  2020;32
  6. Hippocampal hub neurons maintain distinct connectivity throughout their lifetime.
    Authors: Bocchio Et al.
    Nat Commun  2020;11:4559
  7. Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
    Authors: Kiritoshi and Neugebauer
    ACS Chem Neurosci  2018;9:2252
  8. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
    Authors: Collins Et al.
    Neuron  2018;98:366
  9. OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
    Authors: Xiao Et al.
    Elife  2018;7
  10. Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
    Authors: Chang and Higley
    Physiol Rep  2018;6:e13747
  11. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  12. Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
    Authors: Sancho and Bloodgood
    Cell Rep  2018;24:2075
  13. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  14. The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival.
    Authors: Maeder Et al.
    Cell  2018;174:1436
  15. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  16. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
    Authors: Lai Et al.
    Neuron  2017;95:591
  17. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368
  18. Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
    Authors: Kim and Cho
    Neuron  2017;95:1129
  19. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
    Authors: Sigler Et al.
    Neuron  2017;94:304
  20. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
    Authors: Li Et al.
    Neuron  2017;94:1155
  21. Rods progressively escape saturation to drive visual responses in daylight conditions.
    Authors: Tikidji-Hamburyan Et al.
    Nat Commun  2017;8:1813
  22. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
    Authors: Hull
    Cold Spring Harb Protoc  2017;2017
  23. Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
    Authors: Liu Et al.
    Nature  2016;538:383
  24. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  25. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    PLoS One  2015;5:12511
  26. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Sci Rep  2015;35:5680
  27. Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
    Authors: Tsutsui-Kimura Et al.
    Neuron  2015;18
  28. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Neurochem Int  2015;10:e0131430
  29. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One  2014;9:e106148
  30. Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex.
    Authors: Bortone Et al.
    J Neurosci  2014;82:474
  31. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci  2014;31:57
  32. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
    Authors: Bloodgood Et al.
    Nature  2013;503:121
  33. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
    Authors: He Et al.
    Int J Neuropsychopharmacol  2013;109:1535
  34. Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.
    Authors: Gensel Et al.
    J Neurosci  2012;7:e33519
  35. Gain control by layer six in cortical circuits of vision.
    Authors: Olsen Et al.
    J Neurophysiol  2012;483:47
  36. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  37. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain  2012;135:3320
  38. SAP102 is a highly mobile MAGUK in spines.
    Authors: Zheng Et al.
    J Neurosci  2010;30:4757
  39. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab  2006;26:1018
  40. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
    Authors: Harkany Et al.
    PLoS One  2004;24:4978
  41. Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
    Authors: Ronesi Et al.
    J Neurosci  2004;24:1673
  42. Astrocyte-mediated activation of neuronal kainate receptors.
    Authors: Liu Et al.
    Nature  2004;101:3172

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