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Napabucasin

Catalog #: 5522 Datasheet
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5522/10
5522/50
Napabucasin | CAS No. 83280-65-3 | STAT Inhibitors
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Description: STAT3 inhibitor; also blocks cancer stem cell self-renewal

Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione

Purity: ≥98%

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Biological Activity

Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Technical Data

M.Wt:
240.21
Formula:
C14H8O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
83280-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Suppression of cancer relapse and metastasis by inhibiting cancer stemness.
    Li et al.
    Proc.Natl.Acad.Sci.USA., 2015;112:1839

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