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NAADP tetrasodium salt

Catalog #: 3905
5 Citations Datasheet
Catalog # Availability Size / Price Qty
3905/10
NAADP tetrasodium salt | Ryanodine Receptor Modulators
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Description: Ca2+ mobilizing agent
Alternative Names: NAADP

Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.

Technical Data

M.Wt:
832.32
Formula:
C21H23N6Na4O18P3
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NAADP mobilizes calcium from acidic organelles through two-pore channels.
    Calcraft PJ, Ruas M, Pan Z et al.
    Nature
  2. Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes
    Y Miyatake, T Yamano, R Hanayama
    J. Immunol., 2018;0(0):.
  3. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
    Dammerman et al.
    Proc.Natl.Acad.Sci., 2009;106:10678
  4. NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
    Galion
    Biochem.Soc.Transactions, 2006;34:922

Product Datasheets

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Citations for NAADP tetrasodium salt

The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

5 Citations: Showing 1 - 5

  1. Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death.
    Authors: Olimpia Et al.
    NeuroImmune Pharm Ther  2023;2:19-35
  2. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
    Authors: Nicole Et al.
    Elife  2020;9
  3. Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.
    Authors: Hadi Et al.
    Nat Commun  2018;9:5022
  4. Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
    Authors: Ruas Et al.
    Am J Physiol Gastrointest Liver Physiol  2015;NULL
  5. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
    Authors: Wang Et al.
    Cell  2012;151:372

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