N¹,N¹¹-Diethylnorspermine tetrahydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Structural basis for differential induction of spermidine/spermine N¹-acetyltransferase activity by novel spermine analogs.
   Fogel-Petrovic et al.
   Mol.Pharmacol., 1997;52:69
2. Antitumour activity of N¹,N¹²-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts.
   Bernacki et al.
   Cancer Res., 1992;52:2424
3. Characterization of human spermidine spermine N¹-acetyltransferase purified from cultured melanoma cells.
   Libby et al.
   Arch.Biochem.Biophys., 1991;284:238
4. Antitumour activity of N¹,N¹²-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
   Porter et al.
   Cancer Res., 1993;53:581

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