N-Nonyldeoxynojirimycin
Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
Biological Activity
N-Nonyldeoxynojirimycin is a glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.
Andersson et al.
Biochem.Pharmacol., 2004;67:697 -
Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
Mellor et al.
Biochem.J., 2004;381:867 -
Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease.
Sawkar et al.
Proc.Natl.Acad.Sci.USA, 2002;99:15428
Product Datasheets
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