N-Arachidonylglycine

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.
   Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J
   J Biol Chem, 2014;289(19):13079-100.
2. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
   Kohno et al.
   Biochem Biophys Res Commun., 2006;347:827
3. Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells
   McHugh et al.
   Br.J.Pharmacol., 2012;2414:165
4. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
   Edington et al.
   J.Biol.Chem., 2009;284:36424
5. Oxidative metabolism of anandamide.
   Burnstein et al.
   Prostaglandins Other Lipid Mediat., 2000;61:29
6. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
   Huang et al.
   J.Biol.Chem., 2001;276:42639
7. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.
   Sheskin et al.
   J.Med.Chem., 1997;40:659

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