N-Acetylpuromycin
Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Purity: ≥98%
Biological Activity
N-Acetylpuromycin downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals.
Hernández-Damián et al.
Biochim.Biophys.Acta., 2013;1830:5049
Product Datasheets
Citations for N-Acetylpuromycin
The citations listed below are publications that use Tocris products. Selected citations for N-Acetylpuromycin include:
2 Citations: Showing 1 - 2
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A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.
Authors: Alun R Et al.
J Ocul Pharmacol Ther 2020;36:257-266
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Directed differentiation of regulatory T cells from naive T cells and prevention of their inflammation-mediated instability using small molecules.
Authors: Hossein Et al.
Clin Exp Immunol 2020;201:205-221
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