Mycophenolate mofetil
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Purity: ≥99%
Biological Activity
Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF).
Allison and Eugui
Clin.Transplant., 1996;10:77 -
In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil.
Roos et al.
J.Pharm.Exp.Ther., 2007;321:583
Product Datasheets
Citation for Mycophenolate mofetil
The citations listed below are publications that use Tocris products. Selected citations for Mycophenolate mofetil include:
1 Citation: Showing 1 - 1
-
Modulation of immunosuppressant drug treatment to improve SARS-CoV-2 vaccine efficacy in mice.
Authors: Fikri Y Et al.
Vaccine 2022;40:854-861
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Mycophenolate mofetil
There are currently no reviews for this product. Be the first to review Mycophenolate mofetil and earn rewards!
Have you used Mycophenolate mofetil?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
