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MU 1700 trihydrochloride

Catalog #: 8832 Datasheet
Catalog # Availability Size / Price Qty
8832/50
8832/10
MU 1700 trihydrochloride | ALK Inhibitors
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Description: Potent and selective ALK1/2 inhibitor. Brain-penetrant

Chemical Name: 6-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylfuro[3,2-b]pyridine trihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

MU 1700 trihydrochloride is a potent and selective ALK2 and ALK1 inhibitor (IC 50 values are 6 nM and 13 nM, respectively in biochemical assays). It is also a potent ALK6 inhibitor (IC 50 = 41 nM). It shows selectivity for ALK over >360 other kinases. It shows favorable pharmacokinetic for in vivo use. MU 1700 trihydrochloride is orally bioavailable. It is cell membrane permeable and brain penetrant.

Technical Data

M.Wt:
515.86
Formula:
C26H22N4O.3HCl
Solubility:
Soluble to 10 mM in DMSO and to 50 mM in water
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1700 probe summary on the SGC website.

Product Datasheets

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