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MS 154N

Catalog #: 7396 Datasheet
Catalog # Availability Size / Price Qty
7396/5
MS 154N | CAS No. 2675490-97-6 | Active Degrader Negative Controls
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Description: Negative control for MS 154 (Cat No. 7395)

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide

Purity: ≥98%

Product Details
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Biological Activity

MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Technical Data

M.Wt:
915.46
Formula:
C47H56ClFN8O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2675490-97-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Icahn School of Medicine at Mount Sinai.

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