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MS 143

Catalog #: 8081 Datasheet
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8081/5
MS 143 | CAS No. 2376137-41-4 | Active Degraders
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Description: AKT kinase Degrader (PROTAC®)

Chemical Name: 4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Purity: ≥97%

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Biological Activity

MS 143 is a potent and selective protein kinase B (AKT) Degrader (PROTAC®) (DC50 = 46 nM, Dmax = 100 % at 24h in PC3 cells). MS 143 suppresses growth in prostate cancer PC3 cells; suppresses tumor growth and reduces AKT protein levels in a mouse PC3 cell xenograft model.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1121.89
Formula:
C59H81ClN12O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
2376137-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Icahn School of Medicine at Mount Sinai.

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