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MS 023 dihydrochloride

Catalog #: 5713
3 Citations Datasheet
Catalog # Availability Size / Price Qty
5713/10
MS 023 dihydrochloride | CAS No. 1992047-64-9 | Protein Arginine Methyltransferase Inhibitors
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Description: Potent and selective type I PRMT inhibitor

Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

Technical Data

M.Wt:
360.32
Formula:
C17H25N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1992047-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

Product Datasheets

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Citations for MS 023 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for MS 023 dihydrochloride include:

3 Citations: Showing 1 - 3

  1. A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer.
    Authors: Tang Et al.
    Cell Rep.  2022;38:110417
  2. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
    Authors: Lu Et al.
    Cell  2021;
  3. The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer.
    Authors: Choucair Et al.
    Oncogene  2019;38:4015

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