Mouse VEGFR1/Flt-1 Antibody Summary
Ser27-Glu759
Accession # P35969
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: VEGFR1/Flt-1
VEGFR1 (also called Flt-1) is one of the five receptor tyrosine kinases (RTKs) (VEGFR1, KDR/Flk-1, Flt-4, Tie-1, and Tek/Tie-2) whose expression is almost exclusively restricted to the endothelial cells. Tie-1 and Tie-2/Tek define a class of RTKs containing two immunoglobulin-like domains, three EGF homology domains and three fibronectin type III domains in their extracellular regions. VEGFR1/Flt-1, VEGFR2/KDR/Flk-1, VEGFR3/Flt-4 are members of the class III subfamily of RTKs containing seven immunoglobulin-like repeats in their extracellular domains. All five RTKs are likely to play central roles in vasculogenesis and angiogenesis.
Full length mouse VEGFR1 mRNA encodes a 1333 amino acid (aa) residue precursor with a 22 aa residue signal peptide. Mature VEGFR1 is composed of a 737 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 552 aa residue cytoplasmic domain. As a result of alternative splicing of the mRNA, a cDNA encoding a truncated form of VEGFR1, lacking the seventh immunoglobulin-like domain, the transmembrane and intracellular domains, has been cloned. The recombinant soluble VEGFR1/Fc chimera binds VEGF and PlGF with high affinity and is a potent VEGF antagonist.
- He, Y. et al. (1999) Molecular Endocrinology 13:537.
- Ferrara, N. and T. Davis-Smyth (1997) Endocrine Reviews 8:4.
Product Datasheets
Citations for Mouse VEGFR1/Flt-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types
Authors: J Sarkar, Y Luo, Q Zhou, E Ivakhnitsk, D Lara, E Katz, MG Sun, V Guaiquil, M Rosenblatt
PLoS ONE, 2022-07-21;17(7):e0269818.
Species: Human, Rat
Sample Types: Cell Lysates, Whole Cells
Applications: ICC, Immunoprecipitation, Western Blot -
Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain
Authors: AX Xie, N Iguchi, TC Clarkson, AP Malykhina
PLoS ONE, 2022-01-25;17(1):e0262769.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells
Authors: J Falero-Per, N Sheibani, CM Sorenson
PLoS ONE, 2020-05-04;15(5):e0232779.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
1,25(OH)2D3 regulates the proangiogenic activity of pericyte through VDR-mediated modulation of VEGF production and signaling of VEGF and PDGF receptors
Authors: Nasim Jamali, Yong‐Seok Song, Christine M. Sorenson, Nader Sheibani
FASEB BioAdvances
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Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells
Authors: J Falero-Per, YS Song, Y Zhao, L Teixeira, CM Sorenson, N Sheibani
PLoS ONE, 2018-10-29;13(10):e0206756.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain
Authors: Deepitha Selvaraj, Vijayan Gangadharan, Christoph W. Michalski, Martina Kurejova, Sebastian Stösser, Kshitij Srivastava et al.
Cancer Cell
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ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.
Authors: Yang Y, Ahn Y, Chen Y, Tan X, Guo L, Gibbons D, Ungewiss C, Peng D, Liu X, Lin S, Thilaganathan N, Wistuba I, Rodriguez-Canales J, McLendon G, Creighton C, Kurie J
J Clin Invest, 2014-04-24;124(6):2696-708.
Species: Mouse
Sample Types: Protein
Applications: Western Blot -
Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra
Authors: Anil Zechariah, Ayman ElAli, Thorsten R. Doeppner, Fengyan Jin, Mohammad R. Hasan, Iris Helfrich et al.
Stroke
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Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1.
Authors: Mir SU, Jin L, Craven RJ
J. Biol. Chem., 2012-03-14;287(18):14494-501.
Species: Human
Sample Types: Whole Cells
Applications: Western Blot -
Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor.
Authors: Suryawanshi A, Mulik S, Sharma S
J. Immunol., 2011-02-16;186(6):3653-65.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot -
The study of angiogenesis in early rheumatoid arthritis – clinical, immunohistochemical and immunological correlations
Authors: Anca Rosu, Ciurea Ciurea, Simionescu Simionescu, Margaritescu Margaritescu, Musetescu Musetescu, Ciurea Ciurea et al.
J Med Life
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Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP model.
Authors: Isayeva T, Chanda D, Kallman L, Eltoum IE, Ponnazhagan S
Cancer Res., 2007-06-15;67(12):5789-97.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P
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