Mouse TRAIL R2/TNFRSF10B Antibody Summary
Asn53-Ser177 (predicted)
Accession # Q9QZM4
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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TRAIL R2/TNFRSF10B in Mouse Brain. TRAIL R2/TNFRSF10B was detected in perfusion fixed frozen sections of mouse brain (cerebellum) using Rat Anti-Mouse TRAIL R2/TNFRSF10B Monoclonal Antibody (Catalog # MAB1540) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counter-stained with hematoxylin (blue). Specific staining was localized to cytoplasm of Purkinje neurons. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TRAIL R2/TNFRSF10B
Mouse TRAIL R2, also called DR5, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). Mouse TRAIL R2 cDNA encodes a 381 amino acid (aa) precursor protein containing an extracellular cysteine-rich domain, a transmembrane domain and a cytoplasmic death domain. Human and mouse TRAIL R2 share 49% aa sequence similarity. The death domains of human TRAIL R1 and TRAIL R2 share high homology with the death domain of mouse TRAIL R2, 76% and 79%, respectively. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. Besides the death domain containing receptors TRAIL R2 and TRAIL R1/DR4, three TRAIL decoy receptors, TRAIL R3/DcR1, TRAIL R4/DcR2, and OPG, have been reported.
- Chaudhary, P.M. et al. (1997) Immunity 7:821.
- Walczak, H. et al. (1997) EMBO J. 16:5386.
- Golstein, P. (1997) Curr. Biol. 7:R750.
- Wu, G.S. et al. (1999) Cancer Research 59:2770.
Product Datasheets
Citations for Mouse TRAIL R2/TNFRSF10B Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation.
Authors: Kichev A, Rousset C, Baburamani A, Levison S, Wood T, Gressens P, Thornton C, Hagberg H
J Biol Chem, 2014-02-07;289(13):9430-9.
Species: Mouse
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC-P, Western Blot -
Combination treatment with VPA and MSCs‑TRAIL could increase anti‑tumor effects against intracranial glioma
Authors: Soon A. Park, Hye Rim Han, Stephen Ahn, Chung Heon Ryu, Sin‑Soo Jeun
Oncology Reports
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