Mouse TIMP-1 Antibody Summary
Cys25-Arg205
Accession # P12032
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TIMP-1
Tissue inhibitors of metalloproteinases or TIMPs are a family of homologous proteins that regulate the activity of matrix metalloproteinases (MMPs) (1, 2). There are four known members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 that have been found to exhibit multiple functions, including inhibition of active MMPs, pro-MMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis, and the induction of apoptosis. Structurally, TIMPs have two domains, an N‑terminal domain and a C-terminal domain. Each domain consists of three disulfide-bonded loops. TIMP-1 is a glycoprotein produced by a wide range of cell types. Through its N-terminal domain, TIMP-1 inhibits active MMPs by forming a non-covalent binary complex with the MMP active site. The C-terminal domain of TIMP-1 interacts with the C-terminal domain of pro-MMP-9, which may play a role in regulating pro-MMP-9 activation.
- Murphy, G. and F. Willenbrock (1995) Methods Enzymol. 248:496.
- Brew, K. et al. (2000) Biochim. Biophys. Acta 1477:267.
Product Datasheets
Citations for Mouse TIMP-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Authors: M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun
Science Advances, 2021-10-13;7(42):eabi6648.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction
Authors: D Lu, Y Liao, SH Zhu, QC Chen, DM Xie, JJ Liao, X Feng, MH Jiang, W He
Stem Cell Res Ther, 2019-04-27;10(1):127.
Species: N/A
Sample Types: Recombinant Protein
Applications: Western Blot -
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice
Authors: JM Adrian-Seg, K Sreenivasa, P Gajawada, H Lörchner, T Braun, J Pöling
J. Biol. Chem., 2018-10-29;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells
Authors: Takeshi Umazume, William M. Thomas, Sabrina Campbell, Hema Aluri, Suharika Thotakura, Driss Zoukhri et al.
Investigative Opthalmology & Visual Science
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TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis.
Authors: Davidsen ML, Wurtz SØ, Romer MU, Sorensen NM, Johansen SK, Christensen IJ, Larsen JK, Offenberg H, Brunner N, Lademann U
Br. J. Cancer, 2006-10-23;95(8):1114-20.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
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