Mouse TGF-beta RII APC-conjugated Antibody Summary
Ile24-Asp184
Accession # Q62312
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TGF‑ beta RII in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TGF-beta RII APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB532A, filled histogram) or isotype control antibody (Catalog # IC108A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TGF-beta RII
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
The recombinant soluble TGF-beta Type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta Type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta.
Product Datasheets
Citations for Mouse TGF-beta RII APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-beta
Authors: Henrique Borges Borges da Silva, Changwei Peng, Haiguang Wang, Kelsey M. Wanhainen, Chaoyu Ma, Sharon Lopez et al.
Immunity
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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
Authors: P Chakrabort, RY Parikh, S Choi, D Tran, M Gooz, ZT Hedley, DS Kim, D Pytel, I Kang, SN Nadig, GC Beeson, L Ball, M Mehrotra, H Wang, S Berto, V Palanisamy, H Li, S Chatterjee, PC Rodriguez, EN Maldonado, JA Diehl, VK Gangaraju, S Mehrotra
Cancer Research, 2022-05-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFbeta signaling in mice
Authors: M Hu, Y Lu, S Wang, Z Zhang, Y Qi, N Chen, M Shen, F Chen, M Chen, L Yang, S Chen, D Zeng, F Wang, Y Su, Y Xu, J Wang
Cell Death and Differentiation, 2021-08-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-? signaling
Authors: EA Ansa-Addo, Y Zhang, Y Yang, GS Hussey, BV Howley, M Salem, B Riesenberg, S Sun, DC Rockey, S Karvar, PH Howe, B Liu, Z Li
J. Clin. Invest, 2017-03-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Authors: Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
Nat Commun, 2015-02-19;6(0):6329.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
MicroRNAs are implicated in the suppression of CD4+CD25- conventional T cell proliferation by CD4+CD25+ regulatory T cells.
Authors: Zhou S, Dong X, Zhang C, Chen X, Zhu J, Li W, Song X, Xu Z, Zhang W, Yang X, Li Y, Liu F, Sun C
Mol Immunol, 2015-02-01;63(2):464-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
J Clin Invest, 2013-12-20;124(1):448-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
PARP-1 regulates expression of TGF-beta receptors in T cells.
Authors: Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W
Blood, 2013-08-12;122(13):2224-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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