Mouse/Rat Leptin Quantikine ELISA Kit Summary
Product Summary
Precision
Cell Culture Supernates, Tissue Homogenates, Mouse Serum, Rat Serum, Mouse EDTA Plasma, Rat EDTA Plasma, Mouse Heparin Plasma, Rat Heparin Plasma
Intra-Assay Precision | Inter-Assay Precision | |||||
---|---|---|---|---|---|---|
Sample | 1 | 2 | 3 | 1 | 2 | 3 |
n | 20 | 20 | 20 | 20 | 20 | 20 |
Mean (pg/mL) | 152 | 421 | 1512 | 143 | 389 | 1469 |
Standard Deviation | 5.4 | 8.58 | 41 | 11.1 | 30.5 | 87.2 |
CV% | 3.6 | 2 | 2.7 | 7.8 | 7.8 | 5.9 |
Recovery
The recovery of mouse/rat Leptin spiked to levels throughout the range of the assay in various matrices was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
Mouse Cell Culture Media (n=4) | 109 | 98-117 |
Mouse EDTA Plasma (n=4) | 96 | 89-110 |
Mouse Heparin Plasma (n=4) | 90 | 80-105 |
Mouse Serum (n=4) | 95 | 90-102 |
Rat EDTA Plasma (n=4) | 106 | 99-113 |
Rat Heparin Plasma (n=4) | 98 | 91-108 |
Rat Serum (n=4) | 98 | 91-103 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: Leptin/OB
Leptin is a product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of leptin are obese and diabetic, and have reduced activity, metabolism, and body temperature. Rat leptin shares approximately 96% and 82% sequence identity with the mouse and human protein, respectively. The expression of leptin mRNA is restricted to adipose tissue.
Citations for Mouse/Rat Leptin Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Light-responsive adipose-hypothalamus axis controls metabolic regulation
Authors: Tsuji, T;Tolstikov, V;Zhang, Y;Huang, TL;Camara, H;Halpin, M;Narain, NR;Yau, KW;Lynes, MD;Kiebish, MA;Tseng, YH;
Nature communications
Species: Mouse
Sample Types: Plasma
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Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner
Authors: Steiner, BM;Benvie, AM;Lee, D;Jiang, Y;Berry, DC;
Nature communications
Species: Transgenic Mouse
Sample Types: Serum
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Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues
Authors: Zhang, X;Majumdar, A;Kim, C;Kleiboeker, B;Magee, KL;Learman, BS;Thomas, SA;Lodhi, IJ;MacDougald, OA;Scheller, EL;
bioRxiv : the preprint server for biology
Species: Transgenic Mouse
Sample Types: Plasma
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Long-term Metabolic Effects of Non-Nutritive Sweeteners
Authors: Rathaus, M;Azem, L;Livne, R;Ron, S;Ron, I;Hadar, R;Efroni, G;Amir, A;Braun, T;Haberman, Y;Tirosh, A;
Molecular metabolism
Species: Mouse
Sample Types: Plasma
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Anorexia-Induced Hypoleptinemia Drives Adaptations in the JAK2/STAT3 Pathway in the Ventral and Dorsal Hippocampus of Female Rats
Authors: Targa, G;Mottarlini, F;Rizzi, B;Taddini, S;Parolaro, S;Fumagalli, F;Caffino, L;
Nutrients
Species: Rat
Sample Types: Plasma
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IL-1? is required for T cell driven weight loss after respiratory viral infection
Authors: Wang, Z;Cuthbertson, LF;Thomas, C;Sallah, HJ;Mosscrop, LG;Li, H;Talts, T;Kumar, K;Moffatt, MF;Tregoning, JS;
Mucosal immunology
Species: Mouse
Sample Types: Serum
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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R
Authors: Lund, C;Ranea-Robles, P;Falk, S;Rausch, DM;Skovbjerg, G;Vibe-Petersen, VK;Krauth, N;Skytte, JL;Vana, V;Roostalu, U;Pers, TH;Lund, J;Clemmensen, C;
Nature communications
Species: Mouse, Transgenic Mouse
Sample Types: Plasma
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Calcitriol attenuates poly(I:C)-induced lung injury in obese mice via modulating toll-like receptor 3- and renin-angiotensin system-associated signal pathways
Authors: Yeh, CL;Wu, JM;Chen, KY;Wu, MH;Yang, PJ;Lee, PC;Chen, PD;Kuo, TC;Yeh, SL;Lin, MT;
International immunopharmacology
Species: Mouse
Sample Types: Plasma
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Fish oil-derived n-3 polyunsaturated fatty acids downregulate aquaporin 9 protein expression of liver and white adipose tissues in diabetic KK mice and 3T3-L1 adipocytes
Authors: Iizuka, Y;Hirako, S;Kim, H;Wada, N;Ohsaki, Y;Yanagisawa, N;
The Journal of nutritional biochemistry
Species: Mouse
Sample Types: Cell Culture Supernates, Plasma
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Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21
Authors: Klein Hazebroek, M;Laterveer, R;Kutschke, M;Ramak Mar?eta, V;Barthem, CS;Keipert, S;
Scientific reports
Species: Mouse
Sample Types: Serum
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A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
Authors: Southwell, N;Primiano, G;Nadkarni, V;Attarwala, N;Beattie, E;Miller, D;Alam, S;Liparulo, I;Shurubor, YI;Valentino, ML;Carelli, V;Servidei, S;Gross, SS;Manfredi, G;Chen, Q;D'Aurelio, M;
EMBO molecular medicine
Species: Mouse
Sample Types: Plasma
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[18F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice
Authors: M�ller, L;Power Guerra, N;Schildt, A;Lindner, T;Stenzel, J;Behrangi, N;Bergner, C;Alberts, T;B�hler, D;Kurth, J;Krause, BJ;Janowitz, D;Teipel, S;Vollmar, B;Kuhla, A;
Biomolecules
Species: Mouse
Sample Types: Plasma
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ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Authors: DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn
Experimental & Molecular Medicine, 2023-02-13;0(0):.
Species: Mouse
Sample Types: Plasma
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Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
Authors: T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami
Cell Reports, 2023-01-30;42(2):111940.
Species: Mouse
Sample Types: Serum
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Ceruloplasmin-Deficient Mice Show Dysregulation of Lipid Metabolism in Liver and Adipose Tissue Reduced by a Protein Replacement
Authors: S Raia, A Conti, A Zanardi, B Ferrini, GM Scotti, E Gilberti, G De Palma, S David, M Alessio
International Journal of Molecular Sciences, 2023-01-06;24(2):.
Species: Mouse
Sample Types: Tissue Homogenates
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The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
Authors: D Chamseddin, SA Mahmud, AK Westfall, TA Castoe, RE Berg, MW Pellegrino
Cell Reports, 2022-12-13;41(11):111789.
Species: Mouse
Sample Types: Plasma
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Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity
Authors: N Cuesta, S Fernández-, C Punzón, C Moreno, B Barrocal, V Sreeramkum, M Desco, M Fresno
International Journal of Molecular Sciences, 2022-12-10;23(24):.
Species: Mouse
Sample Types: Serum
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Ras drives malignancy through stem cell crosstalk with the microenvironment
Authors: S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs
Nature, 2022-11-30;0(0):.
Species: Mouse
Sample Types: Plasma
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Blockade of CXXC5-dishevelled interaction inhibits adipogenic differentiation, obesity, and insulin resistance in mice
Authors: SH Seo, D Lee, SH Lee, KY Choi
Scientific Reports, 2022-11-30;12(1):20669.
Species: Mouse
Sample Types: Serum
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Pancreastatin inhibitor PSTi8 balances energy homeostasis by attenuating adipose tissue inflammation in high fat diet fed mice
Authors: UK Goand, S Verma, AP Gupta, R Garg, S Dadge, JR Gayen
Peptides, 2022-11-11;159(0):170902.
Species: Mouse
Sample Types: Serum
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Discovery of PPARgamma and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells
Authors: S Ahn, M Ahn, S Park, S An, IG Park, SY Hwang, J Gong, S Oh, SH Jin, HJ Kim, JH Cheong, Y Byun, M Noh
European Journal of Medicinal Chemistry, 2022-11-10;245(0):114927.
Species: Mouse
Sample Types: Serum
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REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-kappaB activation
Authors: DK Lee, T Kim, J Byeon, M Park, S Kim, J Kim, S Choi, G Lee, C Park, KW Lee, YJ Kwon, JH Lee, YG Kwon, YM Kim
Nature Communications, 2022-10-22;13(1):6303.
Species: Mouse
Sample Types: Plasma
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Metformin Mitigated Obesity-Driven Cancer Aggressiveness in Tumor-Bearing Mice
Authors: CJ Chen, CC Wu, CY Chang, JR Li, YC Ou, WY Chen, SL Liao, JD Wang
International Journal of Molecular Sciences, 2022-08-15;23(16):.
Species: Mouse
Sample Types: Plasma
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Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats
Authors: M Alonso-Ber, A Asensio, A Palou-Marc, J Sánchez, A Palou, F Serra, M Palou
International Journal of Molecular Sciences, 2022-06-29;23(13):.
Species: Rat
Sample Types: Plasma
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beta-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet
Authors: N Melnikov, Y Kamari, M Kandel-Kfi, I Barshack, A Ben-Amotz, D Harats, A Shaish, A Harari
Marine Drugs, 2022-06-29;20(7):.
Species: Mouse
Sample Types: Plasma
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Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats
Authors: B Reynés, M Cifre, A Palou, P Oliver
Nutrients, 2022-05-29;14(11):.
Species: Rat
Sample Types: Serum
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Maternal Consumption of a Cafeteria Diet during Lactation Leads to Altered Diet-Induced Thermogenesis in Descendants after Exposure to a Western Diet in Adulthood
Authors: CA Pomar, C Picó, A Palou, J Sánchez
Nutrients, 2022-05-07;14(9):.
Species: Rat
Sample Types: Plasma
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Bifidobacterium animalis ssp. lactis MG741 Reduces Body Weight and Ameliorates Nonalcoholic Fatty Liver Disease via Improving the Gut Permeability and Amelioration of Inflammatory Cytokines
Authors: MH Do, MJ Oh, HB Lee, CH Kang, G Yoo, HY Park
Nutrients, 2022-05-07;14(9):.
Species: Mouse
Sample Types: Whole Tissue
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Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
Authors: AD McNeilly, A Yianakas, JG Gallagher, J Tarlton, ML Ashford, RJ McCrimmon
Molecular Metabolism, 2022-04-22;61(0):101488.
Species: Mouse
Sample Types: Plasma
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Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants
Authors: J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman
Scientific Reports, 2022-03-08;12(1):4039.
Species: Rat
Sample Types: Plasma
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Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations
Authors: L Zizmare, CN Boyle, S Buss, S Louis, L Kuebler, K Mulay, R Krüger, L Steinhauer, I Mack, M Rodriguez, K Herfert, Y Ritze, C Trautwein
International Journal of Molecular Sciences, 2022-01-20;23(3):.
Species: Rat
Sample Types: Feces
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Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice
Authors: YY Sung, SH Kim, DS Kim
Nutrients, 2022-01-19;14(3):.
Species: Mouse
Sample Types: Serum
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Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring
Authors: B Xue, Y Yu, TG Beltz, F Guo, SG Wei, AK Johnson
Journal of the American Heart Association, 2022-01-11;11(2):e023685.
Species: Rat
Sample Types: Plasma
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High-fat western diet-consumption alters crystalline silica-induced serum adipokines, inflammatory cytokines and arterial blood flow in the F344 rat
Authors: JA Thompson, K Krajnak, RA Johnston, ML Kashon, W McKinney, JS Fedan
Toxicology reports, 2021-12-07;9(0):12-21.
Species: Rat
Sample Types: Serum
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Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects
Authors: P Castillo, M Palou, ZX Yau-Qiu, AM Rodríguez, A Palou, C Picó
Nutrients, 2021-09-18;13(9):.
Species: Rat
Sample Types: Plasma
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Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring
Authors: B Xue, Y Yu, TG Beltz, F Guo, RB Felder, SG Wei, A Kim Johnso
Journal of the American Heart Association, 2021-09-06;0(0):e022170.
Species: Rat
Sample Types: Plasma
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Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development
Authors: P Dhanraj, MB van Heerde, MS Pepper, MA Ambele
Biology, 2021-07-28;10(8):.
Species: Mouse
Sample Types: Plasma
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Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice
Authors: B Leibiger, T Moede, I Valladolid, M Paschen, M Visa, IB Leibiger, PO Berggren
Metabolites, 2021-06-14;11(6):.
Species: Mouse
Sample Types: Cell Culture Superantes
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Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes
Authors: G Tavares, D Marques, C Barra, D Rosendo-Si, A Costa, T Rodrigues, P Gasparini, BF Melo, JF Sacramento, R Seiça, SV Conde, P Matafome
Molecular Metabolism, 2021-04-29;0(0):101241.
Species: Rat
Sample Types: Plasma
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Rat Milk and Plasma Immunological Profile throughout Lactation
Authors: B Grases-Pin, M Abril-Gil, P Torres-Cas, M Castell, MJ Rodríguez-, FJ Pérez-Cano, À Franch
Nutrients, 2021-04-11;13(4):.
Species: Rat
Sample Types: Serum
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Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Authors: JD Plummer, SD Postnikoff, JK Tyler, JE Johnson
Elife, 2021-03-30;10(0):.
Species: Mouse
Sample Types: Plasma
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The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
Authors: Z Zhang, X Chen, YJ Loh, X Yang, C Zhang
Bmc Biology, 2021-03-19;19(1):51.
Species: Mouse
Sample Types: Serum
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Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner
Authors: N Shrestha, J Vidimce, OJ Holland, JSM Cuffe, BR Beck, AV Perkins, AJ McAinch, DH Hryciw
International Journal of Molecular Sciences, 2021-03-14;22(6):.
Species: Rat
Sample Types: Plasma
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Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice
Authors: REM Júnior, LM de Carvalh, D Carlos Dos, GD Cassali, AMC Faria, TU Maioli, ALB Godard
The Journal of nutritional biochemistry, 2021-03-08;0(0):108622.
Species: Mouse
Sample Types: Plasma
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Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome
Authors: JE Pruett, ED Torres Fer, SJ Everman, RM Vinson, K Davenport, MK Logan, SA Ye, DG Romero, LL Yanes Card
International Journal of Molecular Sciences, 2021-03-04;22(5):.
Species: Rat
Sample Types: Plasma
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Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Authors: FJ Ruiz-Ojeda, J Wang, T Bäcker, M Krueger, S Zamani, S Rosowski, T Gruber, Y Onogi, A Feuchtinge, TJ Schulz, R Fässler, TD Müller, C García-Các, M Meier, M Blüher, S Ussar
Molecular Metabolism, 2021-01-07;45(0):101147.
Species: Mouse
Sample Types: Serum
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Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains
Authors: JG Wagner, CE Barkauskas, A Vose, RP Lewandowsk, JR Harkema, RM Tighe
Environmental health perspectives, 2020-11-30;128(11):117009.
Species: Mouse
Sample Types: Plasma
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Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats
Authors: M Portero-Tr, D Rojic-Beck, C Vega-Carba, G Guillazo-B, A Vale-Martí, M Martí-Nico
Sci Rep, 2020-11-09;10(1):19299.
Species: Rat
Sample Types: Plasma
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Anti-Obesity Effects of a Prunus persica and Nelumbo nucifera Mixture in Mice Fed a High-Fat Diet
Authors: J Song, J Kim, HJ Park, H Kim
Nutrients, 2020-11-04;12(11):.
Species: Mouse
Sample Types: Serum
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Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels�due to abnormal pituitary negative feedback
Authors: T Nemoto, T Nakakura, Y Kakinuma
PLoS ONE, 2020-08-27;15(8):e0238223.
Species: Rat
Sample Types: Plasma
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Leptin Distribution in Rat Foetal and Extraembryonic Tissues in Late Gestation: A Physiological View of Amniotic Fluid Leptin
Authors: ZX Yau-Qiu, C Picó, AM Rodríguez, A Palou
Nutrients, 2020-08-21;12(9):.
Species: Rat
Sample Types: Tissue Homogenates
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High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring
Authors: FT Spradley
PLoS ONE, 2020-08-20;15(8):e0237708.
Species: Rat
Sample Types: Plasma
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The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring
Authors: CA Pomar, J Sánchez, A Palou
Nutrients, 2020-08-17;12(8):.
Species: Rat
Sample Types: Breast Milk
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Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice
Authors: LY Herat, NC Ward, AL Magno, EP Rakoczy, MG Kiuchi, MP Schlaich, VB Matthews
World J. Gastroenterol., 2020-06-21;26(23):3225-3235.
Species: Mouse
Sample Types: Serum
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Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats
Authors: NA Al-Sawalha, Y Almahmmod, MS Awawdeh, KH Alzoubi, OF Khabour
PLoS ONE, 2020-06-19;15(6):e0234516.
Species: Rat
Sample Types: Serum
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Comparison of cricket diet with peanut-based and milk-based diets in the recovery from protein malnutrition in mice and the impact on growth, metabolism and immune function
Authors: RS Bergmans, M Nikodemova, VJ Stull, A Rapp, KMC Malecki
PLoS ONE, 2020-06-11;15(6):e0234559.
Species: Mouse
Sample Types: Serum
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Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure
Authors: YM Chao, KLH Wu, PC Tsai, YL Tain, S Leu, WC Lee, JYH Chan
J. Biomed. Sci., 2020-05-23;27(1):68.
Species: Rat
Sample Types: Plasma
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Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ?3 Polyunsaturated Fatty Acids in WAT
Authors: H Sato, Y Taketomi, Y Miki, R Murase, K Yamamoto, M Murakami
Cell Rep, 2020-05-05;31(5):107579.
Species: Mouse
Sample Types: Serum
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Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome
Authors: J Zhai, S Li, M Hu, F Di, J Liu, Y Du
Reprod. Biol. Endocrinol., 2020-04-25;18(1):32.
Species: Rat
Sample Types: Serum
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Retinal innervation tunes circuits that drive nonphotic entrainment to food
Authors: DC Fernandez, R Komal, J Langel, J Ma, PQ Duy, MA Penzo, H Zhao, S Hattar
Nature, 2020-04-22;581(7807):194-198.
Species: Mouse
Sample Types: Plasma
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Effects of Cabbage-Apple Juice Fermented by Lactobacillus plantarum EM on Lipid Profile Improvement and Obesity Amelioration in Rats
Authors: S Park, HK Son, HC Chang, JJ Lee
Nutrients, 2020-04-18;12(4):.
Species: Rat
Sample Types: Serum
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Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk
Authors: RJ Perry, K Lyu, A Rabin-Cour, J Dong, X Li, Y Yang, H Qing, A Wang, X Yang, GI Shulman
J. Clin. Invest., 2020-04-01;130(4):2001-2016.
Species: Rat
Sample Types: Plasma
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Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal
Authors: D Nuzzaci, C Cansell, F Liénard, E Nédélec, S Ben Fradj, J Castel, E Foppen, R Denis, D Grouselle, A Laderrière, A Lemoine, A Mathou, V Tolle, T Heurtaux, X Fioramonti, E Audinat, L Pénicaud, JL Nahon, C Rovère, A Benani
Cell Rep, 2020-03-03;30(9):3067-3078.e5.
Species: Mouse
Sample Types: Plasma
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BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice
Authors: C Xiao, N Liu, H Province, RA Piñol, O Gavrilova, ML Reitman
Mol Metab, 2020-02-29;36(0):100969.
Species: Mouse
Sample Types: Whole Blood
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Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet
Authors: SK Hsieh, NH Lin, YJ Chen, MR Lee, WY Chen, JTC Tzen
Molecules, 2020-02-22;25(4):.
Species: Rat
Sample Types: Whole Blood
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WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole body glucose metabolism
Authors: S Hoshino, M Kobayashi, R Tagawa, R Konno, T Abe, K Furuya, K Miura, H Wakasawa, N Okita, Y Sudo, Y Mizunoe, Y Nakagawa, T Nakamura, H Kawabe, Y Higami
FEBS Open Bio, 2020-02-03;0(0):.
Species: Mouse
Sample Types: Plasma
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Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice
Authors: N Kawao, Y Takafuji, M Ishida, K Okumoto, H Morita, M Muratani, H Kaji
PLoS ONE, 2020-02-03;15(2):e0228685.
Species: Mouse
Sample Types: Serum
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Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice
Authors: CI Gil, M Ost, J Kasch, S Schumann, S Heider, S Klaus
Sci Rep, 2019-12-27;9(1):20120.
Species: Mouse
Sample Types: Plasma
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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Authors: V Frodermann, D Rohde, G Courties, N Severe, MJ Schloss, H Amatullah, CS McAlpine, S Cremer, FF Hoyer, F Ji, ID van Koever, F Herisson, L Honold, GS Masson, S Zhang, J Grune, Y Iwamoto, SP Schmidt, GR Wojtkiewic, IH Lee, K Gustafsson, G Pasterkamp, SCA de Jager, RI Sadreyev, J MacFadyen, P Libby, P Ridker, DT Scadden, K Naxerova, KL Jeffrey, FK Swirski, M Nahrendorf
Nat. Med., 2019-11-07;25(11):1761-1771.
Species: Mouse
Sample Types: Plasma
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Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice
Authors: N Kawao, M Ishida, H Kaji
PLoS ONE, 2019-10-24;14(10):e0224403.
Species: Mouse
Sample Types: Serum
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The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity
Authors: P Siriarchav, MC Kruger, MR Miller, HS Tian, FM Wolber
Nutrients, 2019-07-15;11(7):.
Species: Rat
Sample Types: Plasma
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Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1
Authors: C Gougoula, AP Bielfeld, SJ Pour, M Sager, JS Krüssel, WPM Benten, DM Baston-Büs
PLoS ONE, 2019-07-12;14(7):e0219604.
Species: Mouse
Sample Types: Plasma
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A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells
Authors: AB Silva Risc, NIP Neto, K Gascho, M Carnier, DA de Miranda, FP Silva, VT Boldarine, M Seelaender, EB Ribeiro, LM Oyama, CM Oller do N
PLoS ONE, 2019-06-18;14(6):e0218567.
Species: Rat
Sample Types: Serum
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Elevated leptin levels induce inflammation through IL-6 in skeletal muscle of aged female rats
Authors: R Tazawa, K Uchida, H Fujimaki, M Miyagi, G Inoue, H Sekiguchi, K Murata, K Takata, A Kawakubo, M Takaso
BMC Musculoskelet Disord, 2019-05-10;20(1):199.
Species: Rat
Sample Types: Plasma
-
High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus
Authors: E ?ebrowska, M Maciejczyk, M ?endzian-P, A Zalewska, A Chabowski
Int J Mol Sci, 2019-03-28;20(7):.
Species: Rat
Sample Types: Plasma
-
Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration
Authors: JA Deis, H Guo, Y Wu, C Liu, DA Bernlohr, X Chen
Mol Metab, 2019-03-20;0(0):.
Species: Mouse
Sample Types: Serum
-
Chronically reduced BDNF levels increase oxidative stress in epididymal, but not subcutaneous, adipose tissue following high sucrose and high fat diets fed mice
Authors: A Bodur, ? ?nce, C Kahraman, ? Abidin, S Aydin-Abid, A Alver
Arch. Biochem. Biophys., 2019-02-21;0(0):.
Species: Mouse
Sample Types: Serum
-
Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice
Authors: M Pierard, A Tassin, S Conotte, K Zouaoui Bo, A Legrand
Front Physiol, 2019-02-08;10(0):68.
Species: Mouse
Sample Types: Plasma
-
Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction
Authors: D Kain, AJ Simon, A Greenberg, D Ben Zvi, B Gilburd, J Schneiderm
PLoS ONE, 2018-10-12;13(10):e0203902.
Species: Mouse
Sample Types: Plasma
-
Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats
Authors: A Mosqueda-S, J Sánchez, B Reynés, M Palou, MP Portillo, A Palou, C Picó
Sci Rep, 2018-10-10;8(1):15100.
Species: Rat
Sample Types: Plasma
-
Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
Authors: G Wang, N Mohammadtu, Y Lv, H Zhang, J Sun, J Dong
Evid Based Complement Alternat Med, 2018-10-08;2018(0):7591348.
Species: Rat
Sample Types: Serum
-
Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice
Authors: KA Philbrick, AJ Branscum, CP Wong, RT Turner, UT Iwaniec
Sci Rep, 2018-10-04;8(1):14790.
Species: Mouse
Sample Types: Serum
-
Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect
Authors: CS Seo, SR Yoo, SJ Jeong, H Ha
Saudi Pharm J, 2018-09-11;27(1):145-153.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals Lactobacillus paracasei and Escherichia coli
Authors: A Tazi, JR Araujo, C Mulet, ET Arena, G Nigro, T Pédron, PJ Sansonetti
MBio, 2018-09-04;9(5):.
Species: Mouse
Sample Types: Serum
-
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Authors: A Ravussin, YH Youm, J Sander, S Ryu, K Nguyen, L Varela, GI Shulman, S Sidorov, TL Horvath, JL Schultze, VD Dixit
Cell Rep, 2018-07-31;24(5):1085-1092.e6.
Species: Mouse
Sample Types: Serum
-
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life
Authors: A Deodati, J Argemí, D Germani, A Puglianiel, A Alisi, C De Stefani, R Ferrero, V Nobili, T Aragón, S Cianfarani
PLoS ONE, 2018-06-13;13(6):e0198490.
Species: Rat
Sample Types: Plasma
-
Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors
Authors: M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos
Mol. Cancer Ther., 2018-04-25;0(0):.
Species: Mouse
Sample Types: Plasma
-
Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiency
Authors: M Masarwi, R Shamir, M Phillip, G Gat-Yablon
J. Endocrinol., 2018-04-03;0(0):.
Species: Rat
Sample Types: Serum
-
Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice
Authors: F Pan, L Zhang, M Li, Y Hu, B Zeng, H Yuan, L Zhao, C Zhang
Microbiome, 2018-03-21;6(1):54.
Species: Mouse
Sample Types: Serum
-
Deletion of the cold thermoreceptor TRPM8 increases heat loss and food intake leading to reduced body temperature and obesity in mice
Authors: A Reimúndez, C Fernández-, G García, R Fernández, P Ordás, R Gallego, JL Pardo-Vazq, V Arce, F Viana, R Señarís
J. Neurosci., 2018-03-12;0(0):.
Species: Mouse
Sample Types: Serum
-
Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
Authors: DV Chartoumpe, Y Yagishita, M Fazzari, DL Palliyagur, UN Rao, A Zaravinos, NK Khoo, FJ Schopfer, KR Weiss, GK Michalopou, I Sipula, RM O'Doherty, TW Kensler, N Wakabayash
JCI Insight, 2018-03-08;3(5):.
Species: Mouse
Sample Types: Plasma
-
Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver
Authors: C Cai, T Ahmad, GB Valencia, JV Aranda, J Xu, KD Beharry
Growth Horm. IGF Res., 2018-03-08;0(0):.
Species: Rat
Sample Types: Tissue Homogenates
-
Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans
Authors: M Stadion, K Schwerbel, A Graja, C Baumeier, M Rödiger, W Jonas, C Wolfrum, H Staiger, A Fritsche, HU Häring, N Klöting, M Blüher, P Fischer-Po, TJ Schulz, HG Joost, H Vogel, A Schürmann
Diabetologia, 2018-02-24;0(0):.
Species: Mouse
Sample Types: Plasma
-
Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice
Authors: GY Lee, CY Park, KS Cha, SE Lee, M Pae, SN Han
J. Nutr. Biochem., 2018-01-31;55(0):178-184.
Species: Mouse
Sample Types: Serum
-
The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF
Authors: G Scabia, I Barone, M Mainardi, G Ceccarini, M Scali, E Buzzigoli, A Dattilo, P Vitti, A Gastaldell, F Santini, T Pizzorusso, L Maffei, M Maffei
Sci Rep, 2018-01-29;8(1):1781.
Species: Mouse
Sample Types: Plasma
-
Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity
Authors: X Zheng, S Niu
Biochem. Biophys. Res. Commun., 2017-12-30;0(0):.
Species: Rat
Sample Types: Serum
-
Adipose Tissue Deficiency of Hormone-Sensitive Lipase Causes Fatty Liver in Mice
Authors: B Xia, GH Cai, H Yang, SP Wang, GA Mitchell, JW Wu
PLoS Genet., 2017-12-12;13(12):e1007110.
Species: Mouse
Sample Types: Plasma
-
Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes
Authors: M Rödiger, MW Werno, I Wilhelmi, C Baumeier, D Hesse, N Wettschure, S Offermanns, K Song, M Krau beta, A Schürmann
Mol Metab, 2017-11-22;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop
Authors: L Maurer, H Tang, JK Haumesser, J Altschüler, AA Kühn, J Spranger, C van Riesen
Sci Rep, 2017-11-14;7(1):15555.
Species: Mouse
Sample Types: Serum
-
Specific Features of the Hypothalamic Leptin Signaling Response to Cold Exposure Are Reflected in Peripheral Blood Mononuclear Cells in Rats and Ferrets
Authors: B Reynés, M Klein Haze, E García-Rui, J Keijer, P Oliver, A Palou
Front Physiol, 2017-08-15;8(0):581.
Species: Rat
Sample Types: Serum
-
Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
Authors: C Baumeier, L Schlüter, S Saussentha, T Laeger, M Rödiger, SA Alaze, L Fritsche, HU Häring, N Stefan, A Fritsche, RW Schwenk, A Schürmann
Mol Metab, 2017-08-04;6(10):1254-1263.
Species: Mouse
Sample Types: Plasma
-
Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats
Authors: CF Theriau, MK Connor
Physiol Rep, 2017-07-01;5(13):.
Species: Rat
Sample Types: Tissue Culture Supernates
-
Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring
Authors: MH Lejonklou, L Dunder, E Bladin, V Pettersson, M Rönn, L Lind, TB Waldén, PM Lind
Environ. Health Perspect., 2017-06-28;125(6):067018.
Species: Rat
Sample Types: Plasma
-
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
Authors: S Steven, M Oelze, A Hanf, S Kröller-Sc, F Kashani, S Roohani, P Welschof, M Kopp, U Gödtel-Arm, N Xia, H Li, E Schulz, KJ Lackner, L Wojnowski, SP Bottari, P Wenzel, E Mayoux, T Münzel, A Daiber
Redox Biol, 2017-06-22;13(0):370-385.
Species: Rat
Sample Types: Serum
-
Effects of mild calorie restriction on lipid metabolism and inflammation in liver and adipose tissue
Authors: CY Park, S Park, MS Kim, HK Kim, SN Han
Biochem. Biophys. Res. Commun., 2017-06-17;0(0):.
Species: Mouse
Sample Types: Serum
-
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
Authors: MS Lee, Y Shin, S Jung, Y Kim
Food Nutr Res, 2017-05-26;61(1):1325307.
Species: Mouse
Sample Types: Plasma
-
ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Authors: Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich
Mol Metab, 2017-05-06;6(7):725-736.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease
Authors: EK Clemensson, LE Clemensson, B Fabry, O Riess, HP Nguyen
PLoS ONE, 2017-03-08;12(3):e0173232.
Species: Rat
Sample Types: Serum
-
Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice
Authors: RA Zwamborn, RC Slieker, PC Mulder, I Zoetemelk, L Verschuren, HE Suchiman, KH Toet, S Droog, PE Slagboom, T Kooistra, R Kleemann, BT Heijmans
Sci Rep, 2017-03-03;7(0):43261.
Species: Mouse
Sample Types: Plasma
-
Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction
Authors: N Fujii, T Narita, N Okita, M Kobayashi, Y Furuta, Y Chujo, M Sakai, A Yamada, K Takeda, T Konishi, Y Sudo, I Shimokawa, Y Higami
Aging Cell, 2017-03-03;0(0):.
Species: Mouse
Sample Types: Plasma
-
Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain
Authors: MV Morabito, Y Ravussin, BR Mueller, AA Skowronski, K Watanabe, KS Foo, SX Lee, A Lehmann, S Hjorth, LM Zeltser, CA LeDuc, RL Leibel
PLoS ONE, 2017-01-20;12(1):e0168226.
Species: Mouse
Sample Types: Serum
-
Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation
PLoS ONE, 2016-12-19;11(12):e0168562.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
Authors: Lisa C Burnett
J. Clin. Invest, 2016-12-12;0(0):.
Species: Mouse
Sample Types: Plasma
-
Traditional medicine, Sobokchukeo?Tang, modulates the inflammatory response in adipocytes and macrophages
Mol Med Rep, 2016-12-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
-
Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats
Authors: FT Spradley, AC Palei, JP Granger
J. Hypertens, 2016-10-01;34(10):1998-2007.
Species: Rat
Sample Types: Plasma
-
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
Mol Metab, 2016-08-05;5(10):869-81.
Species: Mouse
Sample Types: Plasma
-
Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
Nutr Res Pract, 2016-07-29;10(5):487-493.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet
Oncotarget, 2016-04-26;7(17):24792-9.
Species: Mouse
Sample Types: Plasma
-
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
Authors: Lytle K, Jump D
PLoS ONE, 2016-01-13;11(1):e0146942.
Species: Mouse
Sample Types: Plasma
-
Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells.
Authors: Mendonsa A, Chalfant M, Gorden L, VanSaun M
PLoS ONE, 2015-04-28;10(4):e0126686.
Species: Mouse
Sample Types: Plasma
-
Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet.
Authors: Zhou L, Jang K, Moon Y, Wagle S, Kim K, Lee K, Park B, Kim J
Sci Rep, 2015-03-23;5(0):9397.
Species: Rat
Sample Types: Plasma
-
Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.
Authors: Mejia P, Trevino-Villarreal J, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh M, Mitchell J
Nat Commun, 2015-01-30;6(0):6050.
Species: Mouse
Sample Types: Serum
-
A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.
Authors: Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T
Am J Pathol, 2014-12-24;185(3):617-30.
Species: Mouse
Sample Types: Serum
-
Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats.
Authors: de Almeida M, Luquetti S, Sabarense C, do Amaral Correa J, dos Reis L, Santos da Conceicao E, Lisboa P, de Moura E, Gameiro J, da Gama M, Lopes F, Garcia R
Lipids Health Dis, 2014-12-22;13(0):200.
Species: Rat
Sample Types: Serum
-
Protopanaxatriol, a novel PPARgamma antagonist from Panax ginseng, alleviates steatosis in mice.
Authors: Zhang Y, Yu L, Cai W, Fan S, Feng L, Ji G, Huang C
Sci Rep, 2014-12-09;4(0):7375.
Species: Mouse
Sample Types: Serum
-
Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.
Authors: Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, Owyang C
Endocrinology, 2014-07-25;155(10):3956-69.
Species: Rat
Sample Types: Plasma
-
A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
Authors: Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, Marota J, Blood A, Breiter H, Mao J
J Neurosci, 2014-07-16;34(29):9779-88.
Species: Rat
Sample Types: Serum
-
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.
Authors: Ishii M, Wang G, Racchumi G, Dyke J, Iadecola C
J Neurosci, 2014-07-02;34(27):9096-106.
Species: Mouse
Sample Types: Plasma
-
Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.
Authors: Hall M, Maready M, Hall J, Stec D
Am J Physiol Endocrinol Metab, 2014-06-17;307(3):E316-25.
Species: Mouse
Sample Types: Plasma
-
PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
Authors: Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, Shulman G, Braun U, Leitges M, Farese R
Mol Endocrinol, 2014-05-30;28(7):1097-107.
Species: Mouse
Sample Types: Serum
-
Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
PLoS ONE, 2014-05-09;9(5):e96305.
Species: Rat
Sample Types: Serum
-
Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.
Authors: Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I
PLoS ONE, 2014-04-07;9(4):e92684.
Species: Mouse
Sample Types: Serum
-
Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling.
Authors: Palou M, Priego T, Romero M, Szostaczuk N, Konieczna J, Cabrer C, Remesar X, Palou A, Pico C
Int J Obes (Lond), 2014-04-03;39(2):339-45.
Species: Rat
Sample Types: Plasma
-
Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.
Authors: Mercer A, Stuart R, Attard C, Otero-Corchon V, Nillni E, Low M
Am J Physiol Endocrinol Metab, 2014-02-11;306(8):E904-15.
Species: Mouse
Sample Types: Plasma
-
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
Authors: Ravussin Y, Xiao C, Gavrilova O, Reitman M
PLoS ONE, 2014-01-17;9(1):e85876.
Species: Mouse
Sample Types: Serum
-
Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs.
Authors: Zhang, Xiaomei, Yang, Ran, Jia, Yan, Cai, Demin, Zhou, Bo, Qu, Xiaoli, Han, Huihua, Xu, Liang, Wang, Linfeng, Yao, Yanan, Yang, Guoqing
Diabetes, 2013-12-30;63(5):1475-87.
Species: Mouse
Sample Types: Plasma
-
Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain.
Authors: Vaill M, Desai B, Harris R
Am J Physiol Endocrinol Metab, 2013-12-17;306(4):E414-23.
Species: Rat
Sample Types: CSF
-
Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice.
Authors: Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, Sun Q
PLoS ONE, 2013-12-09;8(12):e81364.
Species: Mouse
Sample Types: Plasma
-
Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation.
Authors: Konieczna J, Garcia A, Sanchez J, Palou M, Palou A, Pico C
PLoS ONE, 2013-11-28;8(11):e81906.
Species: Rat
Sample Types: Plasma
-
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
Authors: Saucillo, Donte C, Gerriets, Valerie, Sheng, John, Rathmell, Jeffrey, Maciver, Nancie J
J Immunol, 2013-11-22;192(1):136-44.
Species: Mouse
Sample Types: Serum
-
T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance.
Authors: Zhong, Jixin, Rao, Xiaoquan, Braunstein, Zachary, Taylor, Anne, Narula, Vimal, Hazey, Jeffrey, Mikami, Dean, Needleman, Bradley, Rutsky, Jessica, Sun, Qinghua, Deiuliis, Jeffrey, Satoskar, Abhay R, Rajagopalan, Sanjay
Diabetes, 2013-11-12;63(4):1289-302.
Species: Mouse
Sample Types: Serum
-
Obesity induced a leptin-Notch signaling axis in breast cancer.
Authors: Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez R
Int J Cancer, 2013-10-08;134(7):1605-16.
Species: Mouse
Sample Types: Plasma
-
Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.
Authors: Palei A, Spradley F, Granger J
Am J Hypertens, 2013-08-16;26(12):1445-51.
Species: Rat
Sample Types: Serum
-
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
Authors: Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lutjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L
J Exp Med, 2013-01-14;210(2):339-53.
Species: Mouse
Sample Types: Plasma
-
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.
Authors: Yan J, Mei F, Cheng H, Lao D, Hu Y, Wei J, Patrikeev I, Hao D, Stutz S, Dineley K, Motamedi M, Hommel J, Cunningham K, Chen J, Cheng X
Mol Cell Biol, 2012-12-21;33(5):918-26.
Species: Mouse
Sample Types: Plasma
-
Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Authors: Paschos, Georgios, Ibrahim, Salam, Song, Wen-Lian, Kunieda, Takeshig, Grant, Gregory, Reyes, Teresa M, Bradfield, Christop, Vaughan, Cheryl H, Eiden, Michael, Masoodi, Mojgan, Griffin, Julian L, Wang, Fenfen, Lawson, John A, Fitzgerald, Garret A
Nat Med, 2012-11-11;18(12):1768-77.
Species: Mouse
Sample Types: Plasma
-
Obesity and IL-6 interact in modulating the response to endotoxemia in mice.
Cytokine, 2012-09-23;61(1):71-7.
Species: Mouse
Sample Types: Plasma
-
Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
Mol. Cell. Endocrinol., 2012-03-28;358(1):127-34.
Species: Mouse
Sample Types: Serum
-
HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration.
Authors: Chang ML, Yeh HC, Tsou YK
Obesity (Silver Spring), 2012-02-23;20(7):1474-80.
Species: Mouse
Sample Types: Serum
-
Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
Endocrinology, 2011-12-20;153(2):672-82.
Species: Mouse
Sample Types: Serum
-
Castration-induced changes in mouse epididymal white adipose tissue.
Authors: Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, Thompson TC
Mol. Cell. Endocrinol., 2011-07-12;345(1):58-67.
Species: Mouse
Sample Types: Serum
-
Caloric restriction reduces growth of mammary tumors and metastases.
Authors: De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A
Carcinogenesis, 2011-06-10;32(9):1381-7.
Species: Mouse
Sample Types: Serum
-
Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.
Authors: Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG
Obesity (Silver Spring), 2011-04-28;19(8):1586-94.
Species: Mouse
Sample Types: Serum
-
Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
Authors: Lager S, Asterholm IW, Schele E, Jansson N, Nilsson S, Jansson JO, Lonn M, Holmang A
Endocrinology, 2011-02-01;152(4):1336-46.
Species: Mouse
Sample Types: Milk
-
Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
Authors: Sato H, Isogai Y, Masuda S
J. Biol. Chem., 2011-01-25;286(13):11632-48.
Species: Mouse
Sample Types: Serum
-
Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue.
Authors: Wankhade UD, Vella KR, Fox DL
PLoS ONE, 2010-08-23;5(8):e12324.
Species: Mouse
Sample Types: Serum
-
Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.
Authors: Li X, Shridas P, Forrest K, Bailey W, Webb NR
FASEB J., 2010-06-28;24(11):4313-24.
Species: Mouse
Sample Types: Plasma
-
Leptin exacerbates sepsis-mediated morbidity and mortality.
Authors: Shapiro NI, Khankin EV, van Meurs M
J. Immunol., 2010-06-02;185(1):517-24.
Species: Mouse
Sample Types: Plasma
-
Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARgamma related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster.
Authors: Liao FH, Liou TH, Chiu WC, Shieh MJ, Chien YW
Int J Obes (Lond), 2010-05-11;34(11):1608-17.
Species: Hamster
Sample Types: Plasma
-
eNOS plays a major role in adiponectin synthesis in adipocytes.
Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU
Am. J. Physiol. Endocrinol. Metab., 2010-02-02;298(4):E846-53.
Species: Mouse
Sample Types: Plasma
-
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
Diabetes, 2010-01-27;59(4):935-46.
Species: Mouse
Sample Types: Plasma
-
Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life.
Authors: Palou M, Priego T, Sanchez J, Torrens JM, Palou A, Pico C
Endocrinology, 2010-01-12;151(3):1030-41.
Species: Rat
Sample Types: Milk
-
Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
Cytokine, 2009-12-29;49(3):256-63.
Species: Mouse
Sample Types: BALF
-
Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat.
Authors: Schroeder M, Zagoory-Sharon O, Shbiro L, Marco A, Hyun J, Moran TH, Bi S, Weller A
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009-09-30;297(6):R1749-60.
Species: Rat
Sample Types: Plasma
-
Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Authors: Pini M, Fantuzzi G
J. Leukoc. Biol., 2009-09-10;87(1):51-8.
Species: Mouse
Sample Types: Peritoneal Lavage Fluid
-
Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations.
Authors: Barros CC, Almeida SS, Mori MA, Valero VB, Haro AS, Batista EC, Rosa TS, Bacurau RF, Wurtele M, Araujo RC
Int J Obes (Lond), 2009-06-16;33(8):938-44.
Species: Mouse
Sample Types: Serum
-
Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice.
Authors: Columba-Cabezas S, Iaffaldano G, Chiarotti F, Alleva E, Cirulli F
J. Neuroimmunol., 2009-06-02;212(1):10-6.
Species: Mouse
Sample Types: Serum
-
Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.
Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J
J. Clin. Invest., 2009-01-12;119(2):295-304.
Species: Rat
Sample Types: Plasma
-
Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
Lab. Invest., 2008-11-10;89(2):222-30.
Species: Mouse
Sample Types: Plasma
-
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
Authors: Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G
J. Clin. Invest., 2008-09-01;118(9):3160-9.
Species: Mouse
Sample Types: Plasma
-
Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin.
Authors: Zagoory-Sharon O, Schroeder M, Levine A, Moran TH, Weller A
Int J Obes (Lond), 2008-05-06;32(8):1211-21.
Species: Rat
Sample Types: Plasma
-
Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice.
Authors: Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G
Endocrinology, 2008-05-01;149(8):4080-5.
Species: Mouse
Sample Types: Serum
-
Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.
Authors: Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R
J. Bone Miner. Res., 2008-05-01;23(5):584-95.
Species: Mouse
Sample Types: Serum
-
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Authors: Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H
Diabetologia, 2008-04-18;51(6):978-88.
Species: Mouse
Sample Types: Plasma
-
Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.
Authors: Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH
Am. J. Physiol., Cell Physiol., 2008-04-16;294(6):C1542-51.
Species: Mouse
Sample Types: Serum
-
Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase.
Authors: Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH
Int J Obes (Lond), 2008-04-15;32(7):1161-70.
Species: Mouse
Sample Types: Plasma
-
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.
Authors: Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG
Endocrinology, 2008-04-10;149(7):3346-54.
Species: Mouse
Sample Types: Plasma
-
FXR-deficiency confers increased susceptibility to torpor.
Authors: Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B
FEBS Lett., 2007-10-12;581(27):5191-8.
Species: Mouse
Sample Types: Plasma
-
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
Authors: Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR
J. Biol. Chem., 2007-06-07;282(32):23672-8.
Species: Mouse
Sample Types: Serum
-
Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.
Authors: Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K
Am. J. Physiol. Heart Circ. Physiol., 2007-01-12;292(5):H2387-96.
Species: Mouse
Sample Types: Plasma
-
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Authors: Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM
Am. J. Respir. Crit. Care Med., 2006-12-21;175(6):587-94.
Species: Mouse
Sample Types: BALF
-
Impaired adipose tissue development in mice with inactivation of placental growth factor function.
Authors: Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D
Diabetes, 2006-10-01;55(10):2698-704.
Species: Mouse
Sample Types: Tissue Homogenates
-
Integrating genetic and network analysis to characterize genes related to mouse weight.
Authors: Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S
PLoS Genet., 2006-07-05;2(8):e130.
Species: Mouse
Sample Types: Plasma
-
Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats.
Authors: O'Connor SE
Eur. J. Pharmacol., 2006-03-06;534(1):271-9.
Species: Mouse
Sample Types: Plasma
-
Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.
Authors: Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH
Diabetes, 2006-03-01;55(3):716-24.
Species: Rat
Sample Types: CSF
-
Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats.
Authors: Sanchez J, Oliver P, Pico C, Palou A
Pflugers Arch., 2004-04-24;448(5):500-6.
Species: Rat
Sample Types: Serum
-
Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
Authors: Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R
J. Am. Soc. Nephrol., 2004-03-01;15(3):645-9.
Species: Mouse
Sample Types: Serum
-
The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.
Authors: Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R
Endocrinology, 2002-11-01;143(11):4304-9.
Species: Mouse
Sample Types: Serum
-
Leptin accelerates autoimmune diabetes in female NOD mice.
Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
Diabetes, 2002-05-01;51(5):1356-61.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Authors: Yamauchi, T, Kamon, J, Waki, H, Terauchi, Y, Kubota, N, Hara, K, Mori, Y, Ide, T, Murakami, K, Tsuboyama-Kasaoka, N, Ezaki, O, Akanuma, Y, Gavrilova, O, Vinson, C, Reitman, M L, Kagechika, H, Shudo, K, Yoda, M, Nakano, Y, Tobe, K, Nagai, R, Kimura, S, Tomita, M, Froguel, P, Kadowaki, T
Nat Med, 2001-08-01;7(8):941-6.
Species: Mouse
Sample Types: Plasma
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