Home / Cathepsin L / Mouse/Rat Cathepsin L Antibody

Mouse/Rat Cathepsin L Antibody

Catalog #: AF1515
47 Citations 3 Reviews Datasheet
Catalog # Availability Size / Price Qty
AF1515
AF1515-SP
Detection of Mouse and Rat Cathepsin L by Western Blot.
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Product Details
Citations (47)
FAQs
Supplemental Products
Reviews (3)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse/Rat Cathepsin L Antibody Summary

Species Reactivity
Mouse, Rat
Specificity
Detects mouse Cathepsin L in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin L
Thr18-Asn334
Accession # P06797
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse and Rat Cathepsin L antibody by Western Blot. View Larger

Detection of Mouse and Rat Cathepsin L by Western Blot. Western blot shows lysates of rat liver tissue, mouse liver tissue (wild type), and mouse liver tissue (knock out). PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse Cathepsin L Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1515) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). Specific bands were detected for Cathepsin L at approximately 22-38 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry Cathepsin L antibody in Mouse Ovary by Immunohistochemistry (IHC-Fr). View Larger

Cathepsin L in Mouse Ovary. Cathepsin L was detected in perfusion fixed frozen sections of mouse ovary using 15 µg/mL Goat Anti-Mouse Cathepsin L Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1515) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Simple Western Detection of Mouse Cathepsin L antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Mouse Cathepsin L by Simple WesternTM. Simple Western lane view shows lysates of mouse liver tissue and HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. Specific bands were detected for Cathepsin L at approximately 51 and 34 kDa (as indicated) using 10 µg/mL of Goat Anti-Mouse Cathepsin L Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1515) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunohistochemistry Cathepsin L antibody in Mouse Thymus by Immunohistochemistry (IHC-Fr). View Larger

Cathepsin L in Mouse Thymus. Cathepsin L was detected in perfusion fixed frozen sections of mouse thymus using 15 µg/mL Goat Anti-Mouse Cathepsin L Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1515) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence Myc induces cathepsin L expression in beta-cells of pancreatic Islets.(A) Immunohistochemical analyses for CTS B, C, L or S expression (all in red) in combination with staining for the pan-leukocyte marker CD45 (green) in pancreatic islet tumors from the MycERTAM;Bcl-xL animals. Pancreata were harvested from the MycERTAM;Bcl-xL mice treated for 7 d with TAM (Myc-On, 7 days) or control vehicle in place of TAM (Myc-OFF). The islet area is indicated by dotted line. The asterisks indicate the area of tumor represented in the insets. The panels are representatives of at least three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; eight randomized fields per analysis were examined. Scale bars, 100μm. (B) Immunohistochemical analysis for cathepsin L expression in beta-cells of pancreatic islets from MycERTAM;Bcl-xL animals identified by insulin expression. Pancreata were collected from the animals described above. Scale bars represent 25μm. The panels are representatives of three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; ten randomized fields per analysis were examined. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0120348), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence Myc induces cathepsin L expression in beta-cells of pancreatic Islets.(A) Immunohistochemical analyses for CTS B, C, L or S expression (all in red) in combination with staining for the pan-leukocyte marker CD45 (green) in pancreatic islet tumors from the MycERTAM;Bcl-xL animals. Pancreata were harvested from the MycERTAM;Bcl-xL mice treated for 7 d with TAM (Myc-On, 7 days) or control vehicle in place of TAM (Myc-OFF). The islet area is indicated by dotted line. The asterisks indicate the area of tumor represented in the insets. The panels are representatives of at least three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; eight randomized fields per analysis were examined. Scale bars, 100μm. (B) Immunohistochemical analysis for cathepsin L expression in beta-cells of pancreatic islets from MycERTAM;Bcl-xL animals identified by insulin expression. Pancreata were collected from the animals described above. Scale bars represent 25μm. The panels are representatives of three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; ten randomized fields per analysis were examined. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0120348), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Mouse Cathepsin L by Immunocytochemistry/ Immunofluorescence Myc induces cathepsin L expression in beta-cells of pancreatic Islets.(A) Immunohistochemical analyses for CTS B, C, L or S expression (all in red) in combination with staining for the pan-leukocyte marker CD45 (green) in pancreatic islet tumors from the MycERTAM;Bcl-xL animals. Pancreata were harvested from the MycERTAM;Bcl-xL mice treated for 7 d with TAM (Myc-On, 7 days) or control vehicle in place of TAM (Myc-OFF). The islet area is indicated by dotted line. The asterisks indicate the area of tumor represented in the insets. The panels are representatives of at least three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; eight randomized fields per analysis were examined. Scale bars, 100μm. (B) Immunohistochemical analysis for cathepsin L expression in beta-cells of pancreatic islets from MycERTAM;Bcl-xL animals identified by insulin expression. Pancreata were collected from the animals described above. Scale bars represent 25μm. The panels are representatives of three animals assayed at each data point, all immunohistochemical analyses were done in duplicate; ten randomized fields per analysis were examined. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0120348), licensed under a CC-BY license. Not internally tested by R&D Systems.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Cathepsin L

Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinase-type plasminogen activator, which is activated by Cathepsin L cleavage (1). Cathepsin L has also been shown to proteolytically inactivate alpha 1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract (2). These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth (3). In Cathepsin L-deficient mice, it appears to play a critical role in cardiac morphology and function, epidermal homeostasis, regulation of the hair cycle, and MHC class II-mediated antigen presentation in cortical epithelial cells of the thymus (4, 5). Mouse Cathepsin L is synthesized as a 334 amino acid precursor with a signal peptide (residues 1-17), a pro region (residues 18-113), and a mature chain (residues 114-334).

References
  1. Goretzki, L. et al. (1992) FEBS Lett. 297:112.
  2. Taggart, C.C. et al. (2001) J. Biol. Chem. 276:33345.
  3. Gottesman, M.M. and F. Cabral (1981) Biochemistry 20:1659.
  4. Stypmann, J. et al. (2002) Proc. Natl. Acad. Sci. USA 99: 6234.
  5. Reinheckel, T. et al. (2001) Biol. Chem. 382:735.
Entrez Gene IDs
1514 (Human); 13039 (Mouse); 118276442 (Insect)
Alternate Names
Cathepsin L; cathepsin L1; CATL; CTSL; CTSL1; CTSLEC 3.4.22.15; EC 3.4.22; FLJ31037; Major excreted protein; MEP

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Citations for Mouse/Rat Cathepsin L Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

47 Citations: Showing 1 - 10
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  1. Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo
    Authors: Martina Tholen, Larissa E. Hillebrand, Stefan Tholen, Oliver Sedelmeier, Sebastian J. Arnold, Thomas Reinheckel
    Nature Communications
  2. (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
    Authors: Limor Goren, George Zhang, Susmita Kaushik, Paul A. S. Breslin, Yi-Chieh Nancy Du, David A. Foster
    PLOS ONE
  3. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
    Authors: Feng T, Mai S, Roscoe JM et al.
    EMBO Rep.
  4. Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery
    Authors: Bullard WL, Kara M, Gay LA et al.
    PLoS Pathog.
  5. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice
    Authors: Zoe A. Klein, Hideyuki Takahashi, Mengxiao Ma, Massimiliano Stagi, Melissa Zhou, TuKiet T. Lam et al.
    Neuron
  6. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury
    Authors: Y Li, JW Jones, H M C Choi, C Sarkar, MA Kane, EY Koh, MM Lipinski, J Wu
    Cell Death Dis, 2019-07-11;10(7):531.
  7. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses
    Authors: Du H, Wong MY, Zhang T et al.
    Life science alliance
  8. Development of Activity-Based Probes for Cathepsin X
    Authors: Margot G. Paulick, Matthew Bogyo
    ACS Chemical Biology
  9. Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway
    Authors: L Liu, B Doray
    FEBS Open Bio, 2021-05-05;0(0):.
  10. Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
    Authors: Weiss Sadan, T;Itzhak, G;Kaschani, F;Yu, Z;Mahameed, M;Anaki, A;Ben-Nun, Y;Merquiol, E;Tirosh, B;Kessler, B;Kaiser, M;Blum, G;
    Mol. Cell Proteomics
  11. Investigations on Primary Cilia of Nthy-ori 3-1 Cells upon Cysteine Cathepsin Inhibition or Thyrotropin Stimulation
    Authors: Do?ru, AG;Rehders, M;Brix, K;
    International journal of molecular sciences
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
    Authors: H Zhang, Y Chen, F Li, C Wu, W Cai, H Ye, H Su, M He, L Yang, X Wang, K Zhou, W Ni
    Journal of Neuroinflammation, 2023-01-07;20(1):6.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  13. Spatiotemporal organisation of protein processing in the kidney
    Authors: M Polesel, M Kaminska, D Haenni, M Bugarski, C Schuh, N Jankovic, A Kaech, JM Mateos, M Berquez, AM Hall
    Nature Communications, 2022-09-29;13(1):5732.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
    Authors: E Ratto, SR Chowdhury, NS Siefert, M Schneider, M Wittmann, D Helm, W Palm
    Nature Communications, 2022-08-17;13(1):4848.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection
    Authors: Z Cui, C Zeng, F Huang, F Yuan, J Yan, Y Zhao, Y Zhou, W Hankey, VX Jin, J Huang, HF Staats, JI Everitt, GD Sempowski, H Wang, Y Dong, SL Liu, Q Wang
    Oncogene, 2022-07-25;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  16. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
    Authors: T Feng, L Luan, II Katz, M Ullah, VM Van Deerli, JQ Trojanowsk, EB Lee, F Hu
    Acta neuropathologica communications, 2022-03-14;10(1):33.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  17. Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3
    Authors: TT Dang, SH Back
    International Journal of Molecular Sciences, 2021-11-08;22(21):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blots
  18. Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19
    Authors: S Kamle, B Ma, CH He, B Akosman, Y Zhou, CM Lee, WS El-Deiry, K Huntington, O Liang, J Machan, MJ Kang, HJ Shin, E Mizoguchi, CG Lee, JA Elias
    bioRxiv : the preprint server for biology, 2021-02-16;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  19. Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis
    Authors: M Shibamura-, K Yuki, L Hou
    International immunopharmacology, 2021-02-01;93(0):107425.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  20. Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma
    Authors: LM Westermann, L Fleischhau, J Vogel, Z Jenei-Lanz, N Floriano L, L Schau, F Morellini, A Baranowsky, TA Yorgan, G Di Lorenzo, M Schweizer, B de Souza P, NR Guarany, F Sperb-Ludw, F Visioli, T Oliveira S, J Soul, G Hendrickx, JS Wiegert, IVD Schwartz, H Clausen-Sc, F Zaucke, T Schinke, S Pohl, T Danyukova
    Dis Model Mech, 2020-11-18;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  21. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
    Authors: S Ketterer, J Mitschke, A Ketscher, M Schlimpert, W Reichardt, N Baeuerle, ME Hess, P Metzger, M Boerries, C Peters, B Kammerer, T Brummer, F Steinberg, T Reinheckel
    Nat Commun, 2020-10-12;11(1):5133.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  22. Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression
    Authors: MA Parigiani, A Ketscher, S Timme, P Bronsert, M Schlimpert, B Kammerer, A Jacquel, P Chaintreui, T Reinheckel
    Cancers (Basel), 2020-07-22;12(8):.
    Species: Mouse
    Sample Types: Cell Culture Lysates
    Applications: Western Blot
  23. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
    Authors: C Sarkar, JW Jones, N Hegdekar, JA Thayer, A Kumar, AI Faden, MA Kane, MM Lipinski
    Autophagy, 2019-06-25;0(0):1-20.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  24. Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis
    Authors: AN Parks, J Nahata, NE Edouard, JS Temenoff, MO Platt
    Sci Rep, 2019-04-01;9(1):5399.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  25. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
    Authors: JK Götzl, AV Colombo, K Fellerer, A Reifschnei, G Werner, S Tahirovic, C Haass, A Capell
    Mol Neurodegener, 2018-09-04;13(1):48.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  26. Stat3 mediated alterations in lysosomal membrane protein composition
    Authors: B Lloyd-Lewi, CC Krueger, TJ Sargeant, ME D'Angelo, MJ Deery, R Feret, JA Howard, KS Lilley, CJ Watson
    J. Biol. Chem., 2018-01-17;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  27. Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines
    Authors: C Cvetkovic, MC Ferrall-Fa, E Ko, L Grant, H Kong, MO Platt, R Bashir
    Sci Rep, 2017-06-19;7(1):3775.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  28. The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target
    Authors: I Khamaysi, P Singh, S Nasser, H Awad, Y Chowers, E Sabo, E Hammond, I Gralnek, I Minkov, A Noseda, N Ilan, I Vlodavsky, Z Abassi
    Sci Rep, 2017-04-06;7(1):715.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy
    Authors: MG Boels, EE van Faasse, MC Avramut, J van der Vl, BM van den Be, TJ Rabelink
    PLoS ONE, 2017-01-19;12(1):e0170065.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  30. Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
    Authors: Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K
    PLoS ONE, 2015-04-30;10(4):e0120348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. Vacuolar ATPase in phagosome-lysosome fusion.
    Authors: Kissing S, Hermsen C, Repnik U, Nesset C, von Bargen K, Griffiths G, Ichihara A, Lee B, Schwake M, De Brabander J, Haas A, Saftig P
    J Biol Chem, 2015-04-22;290(22):14166-80.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  32. Lysosomal protein turnover contributes to the acquisition of TGFbeta-1 induced invasive properties of mammary cancer cells.
    Authors: Kern U, Wischnewski V, Biniossek M, Schilling O, Reinheckel T
    Mol Cancer, 2015-02-15;14(0):39.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  33. The PI3K regulatory subunits p55alpha and p50alpha regulate cell death in vivo.
    Authors: Pensa S, Neoh K, Resemann H, Kreuzaler P, Abell K, Clarke N, Reinheckel T, Kahn C, Watson C
    Cell Death Differ, 2014-06-06;21(9):1442-50.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  34. Biogenesis and proteolytic processing of lysosomal DNase II.
    Authors: Ohkouchi, Susumu, Shibata, Masahiro, Sasaki, Mitsuho, Koike, Masato, Safig, Paul, Peters, Christop, Nagata, Shigekaz, Uchiyama, Yasuo
    PLoS ONE, 2013-03-13;8(3):e59148.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  35. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.
    Authors: Shree T, Olson OC, Elie BT
    Genes Dev., 2011-12-01;25(23):2465-79.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  36. Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, beta-Endorphin, and alpha-MSH, Illustrated by Protease Gene Knockout and Expression.
    Authors: Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V
    J. Biol. Chem., 2008-10-10;283(51):35652-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  37. The impact of microRNAs on protein output.
    Authors: Baek D, Villen J, Shin C, Camargo FD, Gygi SP, Bartel DP
    Nature, 2008-07-30;455(7209):64-71.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  38. Maternal Transmission of a Humanised Igf2r Allele Results in an Igf2 Dependent Hypomorphic and Non-Viable Growth Phenotype
    Authors: Jennifer Hughes, Susana Frago, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan
    PLoS ONE
  39. GCN2 adapts protein synthesis to scavenging-dependent growth
    Authors: Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Hsin-Jung Li, Seunghun Han et al.
    Cell Systems
  40. CCT complex restricts neuropathogenic protein aggregation via autophagy
    Nat Commun, 2016-12-08;7(0):13821.
  41. Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence
    Authors: Chan Li, Zhaoya Liu, Mengshi Chen, Liyang Zhang, Ruizheng Shi, Hua Zhong
    Biology (Basel)
  42. The protease cathepsin L regulates Th17 cell differentiation
    Authors: Lifei Hou, Jessica Cooley, Richard Swanson, Poh Chee Ong, Robert N. Pike, Matthew Bogyo et al.
    Journal of Autoimmunity
  43. Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19
    Authors: Suchitra Kamle, Bing Ma, Chuan Hua He, Bedia Akosman, Yang Zhou, Chang-Min Lee et al.
    JCI Insight
  44. Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization
    Authors: Timothy J. Sargeant, Bethan Lloyd-Lewis, Henrike K. Resemann, Antonio Ramos-Montoya, Jeremy Skepper, Christine J. Watson
    Nature Cell Biology
  45. Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice
    Authors: Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer et al.
    EMBO reports
  46. Acute, Delayed and Chronic Remote Ischemic Conditioning Is Associated with Downregulation of mTOR and Enhanced Autophagy Signaling.
    Authors: Rohailla S, Clarizia N, Sourour M et al.
    PLoS OnE.
  47. Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels
    Authors: Panos G. Ziros, Cédric O. Renaud, Dionysios V. Chartoumpekis, Massimo Bongiovanni, Ioannis G. Habeos, Xiao-Hui Liao et al.
    Thyroid

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Mouse/Rat Cathepsin L Antibody
By Anonymous on 12/06/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: bone marrow macrophage Species: Mouse
Immunocytochemistry/Immunofluorescence Mouse/Rat Cathepsin L Antibody AF1515
Mouse/Rat Cathepsin L Antibody
By Anonymous on 10/17/2018
Application: WB Sample Tested: H4-II-E-C3 rat hepatoma cell line,Hepa 1-6 mouse hepatoma cell line Species: Mouse and Rat
Western Blot Mouse/Rat Cathepsin L Antibody AF1515
Mouse/Rat Cathepsin L Antibody
By Gonzalo Gonzalez on 05/03/2017
Application: WB Sample Tested: mouse feces Species: Mouse
Western Blot Mouse/Rat Cathepsin L Antibody AF1515