Mouse NGFR/TNFRSF16 Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: NGFR/TNFRSF16

The low affinity nerve growth factor receptor (NGF R), also named p75 neurotrophin receptor, is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family and has been designated TNFRSF16. NGF R cDNA encodes a 427 amino acid (aa) residue precursor protein with a 28 aa residue signal peptide, a 222 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 155 aa residue intracellular domain. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3, and NT-4 approximately equally with low affinity. The cytoplasmic region of the receptor contains a subtype 2 death domain.

NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma, and in the amniotic fluid of humans and rats (1-3).

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Cytokine and Growth Factor Receptors on VSMC
• Diabetes
• Glial Lineage Markers
• Mesenchymal Stem Cell Markers
• Microglia Homeostasis
• Neural Crest Cell Markers
• Neurotrophin/Trk Family
• Nogo Proteins and Receptors
• Receptor Tyrosine Kinases (RTKs)
• Regulation of Apoptosis by TNF Superfamily Members
• TNF Superfamily
• TNF Superfamily Receptors
• VPS10P-domain Family