Mouse MMP-7 Antibody Summary
Leu18-Leu264
Accession # AAA99983
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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MMP‑7 in Mouse Intestine. MMP‑7 was detected in perfusion fixed frozen sections of mouse small intestine using Goat Anti-Mouse MMP‑7 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2967) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of cells in intestinal glands. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-7
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican (1). MMP-7 is implicated in the activation of other proteinases such as plasminogen, MMP-1, MMP-2, and MMP-9. In addition to its roles in connective tissue remodeling and cancer, MMP-7 also regulates intestinal alpha ‑defensin activation in innate host defense, releases tumor necrosis factor-alpha in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP-7 is the smallest of the MMPs and consists of two domains: a pro-domain that is cleaved upon activation and a catalytic domain containing the zinc-binding site.
- Woessner, J.F. (2004) in Handbook of Proteolytic Enzymes, Barrett, A.J. et al. eds. p. 532.
Product Datasheets
Citations for Mouse MMP-7 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium
Authors: E Murray, X Cheng, A Krishna, X Jin, TE Ohara, TS Stappenbec, R Bose
Cellular and Molecular Gastroenterology and Hepatology, 2021-04-27;0(0):.
Species: Transgenic Mouse
Sample Types: Whole Tissue
Applications: IHC -
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
Authors: Soledad A Camolotto, Shrivatsav Pattabiraman, Timothy L Mosbruger, Alex Jones, Veronika K Belova, Grace Orstad et al.
eLife
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Authors: YM Nusse, AK Savage, P Marangoni, AKM Rosendahl-, TA Landman, FJ de Sauvage, RM Locksley, OD Klein
Nature, 2018-06-27;559(7712):109-113.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
Authors: K Nalaparedd, KJ Nattamai, RS Kumar, R Karns, KA Wikenheise, LL Sampson, MM Mahe, N Sundaram, MB Yacyshyn, B Yacyshyn, MA Helmrath, Y Zheng, H Geiger
Cell Rep, 2017-03-14;18(11):2608-2621.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis
Authors: Haim Belinson, Adam K. Savage, Douglas Fadrosh, Yien-Ming Kuo, Din Lin, Ricardo Valladares et al.
JCI Insight
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Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition
Oncogene, 2016-07-04;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis
Authors: Takwi Nkyimbeng, Clemens Ruppert, Takayuki Shiomi, Bhola Dahal, György Lang, Werner Seeger et al.
PLoS ONE
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Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models.
Authors: Zhang Q, Liu S, Ge D, Zhang Q, Xue Y, Xiong Z, Abdel-Mageed A, Myers L, Hill S, Rowan B, Sartor O, Melamed J, Chen Z, You Z
Cancer Res, 2012-03-28;72(10):2589-99.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Authors: Littlepage LE, Sternlicht MD, Rougier N
Cancer Res., 2010-03-09;70(6):2224-34.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-Fr, Western Blot -
Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor.
Authors: Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM
Cancer Res., 2007-07-15;67(14):6760-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
Authors: Zhou Y, Rychahou P, Wang Q et al.
Cell Death Dis.
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