Mouse MMP-3 Biotinylated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: MMP-3

Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1) can degrade a broad range of substrates including collagen alpha -chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro-MMP-1, pro-MMP-7, pro-MMP-8, pro-MMP-9, and pro-MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodeling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells, and macrophages. Structurally, MMP-3 may be divided into several distinct domains, a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin-like) domain.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Cell to Cell Adhesion Disassembly During EMT
• Collagen Modifying Enzymes
• EMT Induction
• Enzymes Secreted by Endothelial Cells
• Extracellular Matrix Remodeling and Cell Migration During EMT
• Mesenchymal Cells and EMT
• Metalloproteases and Regulators
• Microglia Activation Markers
• MMPs, TIMPs and Related Molecules
• Neuroinflammatory Factors
• Proteolytic Degradation of Amyloid beta
• Search Bioprocessing Enzymes