Mouse Mer PE-conjugated Antibody Summary
Glu23-Phe498
Accession # Q60805
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry. J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Rat Anti-Mouse Mer PE-conjugated Monoclonal Antibody (Catalog # FAB5912P, filled histogram) or isotype control antibody (Catalog # IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Mer
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1-2).
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Product Datasheets
Citations for Mouse Mer PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
8
Citations: Showing 1 - 8
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Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
Authors: SP Kubli, L Vornholz, G Duncan, W Zhou, P Ramachandr, J Fortin, M Cox, S Han, R Nechanitzk, D Nechanitzk, BE Snow, L Jones, WY Li, J Haight, A Wakeham, MR Bray, TW Mak
Nat Commun, 2019-06-18;10(1):2678.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer
Authors: SP Kubli, C Bassi, C Roux, A Wakeham, C Göbl, W Zhou, SM Jafari, B Snow, L Jones, L Palomero, KL Thu, L Cassetta, D Soong, T Berger, P Ramachandr, SP Baniasadi, G Duncan, M Lindzen, Y Yarden, C Herranz, C Lazaro, MF Chu, J Haight, P Tinto, J Silvester, DW Cescon, A Petit, S Pettersson, JW Pollard, TW Mak, MA Pujana, P Cappello, C Gorrini
Proc. Natl. Acad. Sci. U.S.A., 2019-02-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Authors: CE Macdougall, EG Wood, J Loschko, V Scagliotti, FC Cassidy, ME Robinson, N Feldhahn, L Castellano, MB Voisin, F Marelli-Be, C Gaston-Mas, M Charalambo, MP Longhi
Cell Metab., 2018-03-06;27(3):588-601.e4.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TTI-621 (SIRP?Fc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets
Authors: GHY Lin, V Chai, V Lee, K Dodge, T Truong, M Wong, LD Johnson, E Linderoth, X Pang, J Winston, PS Petrova, RA Uger, NN Viller
PLoS ONE, 2017-10-30;12(10):e0187262.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
NK-, NKT- and CD8-Derived IFNgamma Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia.
Authors: Cnops J, De Trez C, Stijlemans B, Keirsse J, Kauffmann F, Barkhuizen M, Keeton R, Boon L, Brombacher F, Magez S
PLoS Pathog, 2015-06-12;11(6):e1004964.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis.
Authors: Stijlemans, Benoit, Cnops, Jennifer, Naniima, Peter, Vaast, Axel, Bockstal, Viki, De Baetselier, Patrick, Magez, Stefan
PLoS Negl Trop Dis, 2015-03-05;9(3):e0003561.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
GAS6 receptor status is associated with dormancy and bone metastatic tumor formation.
Authors: Taichman, Russell, Patel, Lalit R, Bedenis, Rachel, Wang, Jingchen, Weidner, Savannah, Schumann, Taibrian, Yumoto, Kenji, Berry, Janice E, Shiozawa, Yusuke, Pienta, Kenneth
PLoS ONE, 2013-04-24;8(4):e61873.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Axl inhibition induces the antitumor immune response which can be further potentiated by PD-1 blockade in the mouse cancer models
Authors: Zhiqiang Guo, Yan Li, Dandan Zhang, Jiaying Ma
Oncotarget
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