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Mouse Mer Antibody

Catalog #: AF591
71 Citations 2 Reviews Datasheet
Catalog # Availability Size / Price Qty
AF591
AF591-SP
Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry.
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Product Details
Citations (71)
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Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Mer Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Mer in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross‑reactivity with recombinant human Mer is observed and less than 1% cross-reactivity with recombinant mouse (rm) Axl and rmDtk is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Mer
Glu23-Phe498
Accession # Q60805
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
See below
Immunohistochemistry
1-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Dual RNAscope ISH-IHC
1-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Mer antibody in J774A.1 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry. J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Goat Anti-Mouse Mer Antigen Affinity-purified Polyclonal Antibody (Catalog # AF591, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108).

Immunohistochemistry Mer antibody in Mouse Testis by Immunohistochemistry (IHC-Fr). View Larger

Mer in Mouse Testis. Mer was detected in perfusion fixed frozen sections of mouse testis using Goat Anti-Mouse Mer Antigen Affinity-purified Polyclonal Antibody (Catalog # AF591) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to sperm cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Dual RNAscope ISH-IHC Compatible Mer antibody in Mouse Kidney Using Dual RNAscope<sup>®</sup>ISH and IHC. View Larger

Mer in Mouse Kidney Using Dual RNAscope®ISH and IHC. Mer mRNA was detected in formalin-fixed paraffin-embedded tissue sections of mouse kidney probed with ACD RNAScope®Probe (Catalog # 441241) and stained using ACD RNAscope®2.5 HD Detection Reagents-Red (top image, Catalog # 32260). Adjacent tissue section was processed for immunohistochemistry using R&D Systems Goat Anti-Mouse Mer Antigen Affinity-purified Polyclonal Antibody (Catalog # AF591) at 1 ug/mL with overnight incubation at 4 °C followed by incubation with the Anti-Goat IgG VisUCyte HRP Polymer Antibody (R&D Systems, Catalog # VC004) and DAB chromogen (lower image, yellow-brown). Tissues were counterstained with hematoxylin (blue).

Western Blot Detection of Mouse Mer by Western Blot View Larger

Detection of Mouse Mer by Western Blot RPE express components of BAI1-signaling pathway and Bai1Tg. (A) Expression of the BAI1 signaling pathway was analyzed by quantitative RT-PCR in RPE isolated from P14 Mertk+/− and Mertk−/− mice (n = 2) Error bars represent SEM. (B) Immunoblot analysis of BAI1 signaling pathway in RPE whole cell lysates isolated from P14 mice. Left panel shows representative immunoblots for Mer, Dock180, Elmo2 and Rac. Right panel shows combined densitometry analysis of immunoblots from n = 3 mice per genotype. For densitometry analysis, band volumes were normalized to an actin loading control and band densities in Mertk−/− were then normalized to Mertk+/− for comparison across multiple blots. (C) Schematic of Bai1Tg insertion in the Rosa26 locus indicating the N-terminal HA-tag in red and IRES-GFP in green. Mouse image licensed from Motifolio Inc. (D) GFP expression was analyzed in RPE flat mount preparations at 20x magnification. Inset image in the left panel shows a representative flat mount at 1.2x magnification. White scale bars in images are 50 μm. Images are representative of n = 2 mice per genotype. (E) qRT-PCR analysis of Bai1Tg expression in Mertk+/−Bai1Tg (n = 9) and Mertk−/−Bai1Tg (n = 3) RPE isolated on P14. n.d. = not detected. Error bars represent SEM. (F) Immunoblot analysis of HA-tag (Bai1Tg) in RPE whole cell lysates isolated from P13-P14 mice. Immunoblot shown is representative of n = 2 experiments. (G) HA staining and localization was analyzed in eyecups at 40x magnification. Neural retinas were removed prior to fixation and staining. Black lines next to the figure align with apical microvilli of RPE. Scale bars are 20 μm. Images shown are representative of n = 2 mice per genotype. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/s41598-017-15191-1), licensed under a CC-BY license. Not internally tested by R&D Systems.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Mer

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1, 2).

References
  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Receptor Tyrosine Protein Kinase Mer
Entrez Gene IDs
10461 (Human); 17289 (Mouse); 102143798 (Cynomolgus Monkey)
Alternate Names
c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC 2.7.10.1; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer

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Citations for Mouse Mer Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

71 Citations: Showing 1 - 10
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  1. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
    Authors: Feriotti C, SA-Pessoa J, CalderOn-GonzAlez R et al.
    Cell reports
  2. siRNA nanoparticles targeting CaMKII gamma in lesional macrophages improve atherosclerotic plaque stability in mice
    Authors: Tao W, Yurdagul A, Kong N et al.
    Sci Transl Med
  3. Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release
    Authors: Tufan, T;Comertpay, G;Villani, A;Nelson, GM;Terekhova, M;Kelley, S;Zakharov, P;Ellison, RM;Shpynov, O;Raymond, M;Sun, J;Chen, Y;Bockelmann, E;Stremska, M;Peterson, LW;Boeckaerts, L;Goldman, SR;Etchegaray, JI;Artyomov, MN;Peri, F;Ravichandran, KS;
    Nature
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  4. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
    Authors: Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai et al.
    Cellular and Molecular Gastroenterology and Hepatology
  5. Walnut inclusion in a palm oil-based atherogenic diet promotes traits predicting stable atheroma plaque in Apoe-deficient mice
    Authors: Iolanda Lázaro, Joaquim Bobi, Montserrat Cofán, Garyfallia Kapravelou, Antonio J. Amor, Joaquin Surra et al.
    Frontiers in Nutrition
  6. Anti-inflammatory clearance of amyloid-beta by a chimeric Gas6 fusion protein
    Authors: H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim, S Kim, Y Lee, KH Han, WS Chung, CH Kim
    Nature Medicine, 2022-08-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe -/- Mice
    Authors: Vijayprakash Manickam, Umesh Kumar Dhawan, Damanpreet Singh, Mahesh Gupta, Manikandan Subramanian
    Frontiers in Pharmacology
  8. Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance
    Authors: L Zheng, J Jia, Y Chen, R Liu, R Cao, M Duan, M Zhang, Y Xu
    Journal of Neuroinflammation, 2022-05-31;19(1):128.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ? plaques
    Authors: Roy ER, Chiu G, Li S et al.
    Immunity
  10. Phosphatidylserine released from apoptotic cells in tumor induces M2‐like macrophage polarization through the PSR‐STAT3‐JMJD3 axis
    Authors: Xiao Liang, Min Luo, Bin Shao, Jing‐Yun Yang, An Tong, Rui‐Bo Wang et al.
    Cancer Communications
  11. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages
    Authors: X Huang, C Liu, N Kong, Y Xiao, A Yurdagul, I Tabas, W Tao
    Nature Protocols, 2022-02-04;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Microglia use TAM receptors to detect and engulf amyloid &beta plaques
    Authors: Y Huang, KE Happonen, PG Burrola, C O'Connor, N Hah, L Huang, A Nimmerjahn, G Lemke
    Nature Immunology, 2021-04-15;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
    Authors: Chao-Ju Chen, Yu-Peng Liu
    Pharmaceuticals (Basel)
  14. Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3
    Authors: NJ Esposito, F Mazzoni, JA Vargas, SC Finnemann
    Investigative Ophthalmology & Visual Science, 2021-02-01;62(2):7.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult
    Authors: JM Rosin, CM Marsters, F Malik, R Far, L Adnani, C Schuurmans, QJ Pittman, DM Kurrasch
    Cell Reports, 2021-01-05;34(1):108587.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
    Authors: H Wu, J Zheng, S Xu, Y Fang, Y Wu, J Zeng, A Shao, L Shi, J Lu, S Mei, X Wang, X Guo, Y Wang, Z Zhao, J Zhang
    Journal of Neuroinflammation, 2021-01-05;18(1):2.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
    Authors: C Madore, Q Leyrolle, L Morel, M Rossitto, AD Greenhalgh, JC Delpech, M Martinat, C Bosch-Bouj, J Bourel, B Rani, C Lacabanne, A Thomazeau, KE Hopperton, S Beccari, A Sere, A Aubert, V De Smedt-P, C Lecours, K Bisht, L Fourgeaud, S Gregoire, L Bretillon, N Acar, NJ Grant, J Badaut, P Gressens, A Sierra, O Butovsky, ME Tremblay, RP Bazinet, C Joffre, A Nadjar, S Layé
    Nature Communications, 2020-11-30;11(1):6133.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  18. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
    Authors: Hiroyuki Konishi, Takayuki Okamoto, Yuichiro Hara, Okiru Komine, Hiromi Tamada, Mitsuyo Maeda et al.
    The EMBO Journal
  19. Macrophage-derived vascular endothelial growth factor-A is integral to neuromuscular junction reinnervation after nerve injury
    Authors: CY Lu, K Santosa, A Jablonka-S, B Vannucci, A Fuchs, I Turnbull, D Pan, M Wood, AK Snyder-War
    J Neurosci, 2020-11-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis
    Authors: JC DuBois, AK Ray, P Davies, B Shafit-Zag
    J Neuroinflammation, 2020-10-29;17(1):324.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Functional Assay
  21. Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer
    Authors: Anna Zagórska, Paqui G Través, Lidia Jiménez-García, Jenna D Strickland, Joanne Oh, Francisco J Tapia et al.
    Life Science Alliance
  22. Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis
    Authors: B Moon, J Lee, SA Lee, C Min, H Moon, D Kim, S Yang, H Moon, J Jeon, YE Joo, D Park
    Cells, 2020-07-06;9(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  23. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
    Authors: EC Damisah, RA Hill, A Rai, F Chen, CV Rothlin, S Ghosh, J Grutzendle
    Sci Adv, 2020-06-26;6(26):eaba3239.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IF
  24. A FUNCTIONAL ROLE OF GAS6/TAM IN NON-ALCOHOLIC STEATOHEPATITIS PROGRESSION IMPLICATES AXL AS THERAPEUTIC TARGET
    Authors: A Tutusaus, E de Gregori, B Cucarull, H Cristóbal, C Aresté, I Graupera, M Coll, A Colell, G Gausdal, JB Lorens, P García de, A Morales, M Marí
    Cell Mol Gastroenterol Hepatol, 2019-11-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Gas6/TAM Receptors in Systemic Lupus Erythematosus
    Authors: Philip L. Cohen, Wen-Hai Shao
    Disease Markers
  26. Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo
    Authors: Joel Z. Ma, Wy Ching Ng, Luke Zappia, Linden J. Gearing, Moshe Olshansky, Kym Pham et al.
    Journal of Virology
  27. Pan-TAM tyrosine kinase inhibitor BMS-777607 enhances anti-PD-1 mAb efficacy in a murine model of triple-negative breast cancer
    Authors: RB Birge, C Kasikara, V Davra, D Calianese, K Geng, TE Spires, M Quigley, M Wichroski, G Sriram, L Suarez-Lop, MB Yaffe, SV Kotenko, MS De Lorenzo
    Cancer Res., 2019-03-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance
    Authors: Lei Zhang, Matthew DeBerge, Jiaojin Wang, Anil Dangi, Xiaomin Zhang, Samantha Schroth et al.
    American Journal of Transplantation
  29. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
    Authors: D Aran, AP Looney, L Liu, E Wu, V Fong, A Hsu, S Chak, RP Naikawadi, PJ Wolters, AR Abate, AJ Butte, M Bhattachar
    Nat. Immunol., 2019-01-14;20(2):163-172.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  30. LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux
    Authors: DG Thomas, AC Doran, P Fotakis, M Westerterp, P Antonson, H Jiang, XC Jiang, JÅ Gustafsson, I Tabas, AR Tall
    Cell Rep, 2018-12-26;25(13):3774-3785.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  31. Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation
    Authors: Jennifer M. Felton, Christopher D. Lucas, David A. Dorward, Rodger Duffin, Tiina Kipari, Sonja Vermeren et al.
    Journal of Allergy and Clinical Immunology
  32. MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity
    Authors: Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page et al.
    JCI Insight
  33. Sitravatinib potentiates immune checkpoint blockade in refractory cancer models
    Authors: W Du, H Huang, N Sorrelle, RA Brekken
    JCI Insight, 2018-11-02;3(21):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  34. Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
    Authors: CEJ Waterborg, S Beermann, MGA Broeren, MB Bennink, MI Koenders, PLEM van Lent, WB van den Be, PM van der Kr, FAJ van de Loo
    Front Immunol, 2018-04-13;9(0):742.
    Species: Mouse
    Sample Types: In Vivo, Tissue Homogenates, Whole Cells
    Applications: Activation, Immunoprecipitation, In Vivo, Western Blot
  35. Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury
    Authors: A Brosius Lu, WS Chung, SA Sloan, GA Carson, L Zhou, E Lovelett, S Posada, JB Zuchero, BA Barres
    Proc. Natl. Acad. Sci. U.S.A., 2017-09-05;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  36. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis
    Authors: A Canfrán-Du, N Rotllan, X Zhang, M Fernández-, C Ramírez-Hi, E Araldi, L Daimiel, R Busto, C Fernández-, Y Suárez
    EMBO Mol Med, 2017-09-01;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  37. Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
    Authors: M Bellesi, L de Vivo, M Chini, F Gilli, G Tononi, C Cirelli
    J. Neurosci., 2017-05-24;37(21):5263-5273.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  38. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain
    Authors: A Voronova, SA Yuzwa, BS Wang, S Zahr, C Syal, J Wang, DR Kaplan, FD Miller
    Neuron, 2017-05-03;94(3):500-516.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  39. GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa
    Authors: M Nassar, Y Tabib, T Capucha, G Mizraji, T Nir, M Pevsner-Fi, G Zilberman-, O Heyman, G Nussbaum, H Bercovier, A Wilensky, E Elinav, T Burstyn-Co, AH Hovav
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-03;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  40. MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes
    Sci Rep, 2016-11-09;6(0):36207.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  41. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages
    Sci Rep, 2016-07-13;6(0):29673.
    Species: Mouse
    Sample Types:
  42. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
    Proc Natl Acad Sci USA, 2016-05-19;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  43. TAM receptors regulate multiple features of microglial physiology
    Authors: L Fourgeaud, PG Través, Y Tufail, H Leal-Baile, ED Lew, PG Burrola, P Callaway, A Zagórska, CV Rothlin, A Nimmerjahn, G Lemke
    Nature, 2016-04-06;532(7598):240-4.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  44. Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8+ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling
    Authors: F L Ribeiro-Gomes, A Romano, S Lee, E Roffê, N C Peters, A Debrabant et al.
    Cell Death & Disease
  45. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
    Authors: Jonathan J. Miner, Brian P. Daniels, Bimmi Shrestha, Jose L. Proenca-Modena, Erin D. Lew, Helen M. Lazear et al.
    Nature Medicine
  46. Targeting inflammation in type 2 diabetes by antibody‐mediated Tyro‐3, Axl, Mer receptor activation
    Authors: Chien‐Hsing Lee, Chih‐Ying Changchien, Yi‐Jen Hung
    Journal of Diabetes Investigation
  47. Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells.
    Authors: Kuan E, Ivanov S, Bridenbaugh E, Victora G, Wang W, Childs E, Platt A, Jakubzick C, Mason R, Gashev A, Nussenzweig M, Swartz M, Dustin M, Zawieja D, Randolph G
    J Immunol, 2015-04-27;194(11):5200-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  48. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
    Authors: Savage J, Jay T, Goduni E, Quigley C, Mariani M, Malm T, Ransohoff R, Lamb B, Landreth G
    J Neurosci, 2015-04-22;35(16):6532-43.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC, Western Blot
  49. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration.
    Authors: Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, Housset M, Paques M, Sahel J, Bemelmans A, Combadiere C, Guillonneau X, Sennlaub F
    EMBO Mol Med, 2015-02-01;7(2):211-26.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  50. Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution
    Authors: Jamie C. Stanford, Christian Young, Donna Hicks, Philip Owens, Andrew Williams, David B. Vaught et al.
    Journal of Clinical Investigation
  51. Diversification of TAM receptor tyrosine kinase function.
    Authors: Zagorska A, Traves P, Lew E, Dransfield I, Lemke G
    Nat Immunol, 2014-09-07;15(10):920-8.
    Species: Mouse
    Sample Types: Cell Lysates, In Vivo
    Applications: Immunoprecipitation, Neutralization
  52. Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis.
    Authors: Nascimento M, Huang S, Smith A, Everts B, Lam W, Bassity E, Gautier E, Randolph G, Pearce E
    PLoS Pathog, 2014-08-21;10(8):e1004282.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  53. A new mouse model for female genital schistosomiasis.
    Authors: Richardson, Monica L, Fu, Chi-Ling, Pennington, Luke F, Honeycutt, Jared D, Odegaard, Justin I, Hsieh, Yi-Ju, Hammam, Olfat, Conti, Simon L, Hsieh, Michael
    PLoS Negl Trop Dis, 2014-05-01;8(5):e2825.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Flow Cytometry
  54. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes.
    Authors: Jakubzick C, Gautier E, Gibbings S, Sojka D, Schlitzer A, Johnson T, Ivanov S, Duan Q, Bala S, Condon T, Van Rooijen N, Grainger J, Belkaid Y, Ma'ayan A, Riches D, Yokoyama W, Ginhoux F, Henson P, Randolph G
    Immunity, 2013-09-05;39(3):599-610.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  55. Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors
    Authors: Suchita Bhattacharyya, Anna Zagórska, Erin D. Lew, Bimmi Shrestha, Carla V. Rothlin, John Naughton et al.
    Cell Host & Microbe
  56. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis
    Authors: Rebecca S. Cook, Kristen M. Jacobsen, Anne M. Wofford, Deborah DeRyckere, Jamie Stanford, Anne L. Prieto et al.
    Journal of Clinical Investigation
  57. The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells
    Authors: Hyun-Jung Park, Ji-Yeon Baen, Ye-Ji Lee, Youn-Hee Choi, Jihee Lee Kang
    Molecular Biology of the Cell
  58. Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
    Authors: Brown JE, Krodel M, Pazos M
    PLoS ONE, 2012-05-14;7(5):e36800.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  59. Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
    J. Cell. Sci., 2012-03-16;91(6):921-32.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: ICC, Neutralization
  60. Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells.
    Authors: Galvan MD, Foreman DB, Zeng E
    J. Immunol., 2012-03-14;188(8):3716-23.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  61. An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration
    Authors: Dennis M. Maddox, Wanda L. Hicks, Douglas Vollrath, Matthew M. LaVail, Jürgen K. Naggert, Patsy M. Nishina
    Investigative Opthalmology & Visual Science
  62. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
    Authors: Zhong Z, Wang Y, Guo H, Sagare A, Fernandez JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV
    J. Neurosci., 2010-11-17;30(46):15521-34.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  63. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.
    Authors: Zhu D, Wang Y, Singh I
    Blood, 2010-03-26;115(23):4963-72.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  64. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.
    Authors: Thorp E, Cui D, Schrijvers DM, Kuriakose G, Tabas I
    Arterioscler. Thromb. Vasc. Biol., 2008-05-01;28(8):1421-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  65. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
    Authors: Chang Y, Finnemann SC
    J. Cell. Sci., 2007-08-07;120(0):3053-63.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  66. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
    Authors: Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM, Graham DK
    Blood, 2006-10-17;109(3):1026-33.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  67. Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
    Authors: Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA
    J. Thromb. Haemost., 2005-02-23;3(4):733-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  68. Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models
    Authors: Youtong H, Greg L
    STAR Protocols
  69. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
    Authors: Lew ED, Oh J, Burrola PG et al.
    Elife.
  70. Allograft inflammatory factor-1 supports macrophage survival and efferocytosis and limits necrosis in atherosclerotic plaques
    Authors: Lander Egaña-Gorroño, Prameladevi Chinnasamy, Isabel Casimiro, Vanessa M. Almonte, Dippal Parikh, Gustavo H. Oliveira-Paula et al.
    Atherosclerosis
  71. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia
    Authors: Tufail Y, Cook D, Fourgeaud L et al.
    Neuron

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Mouse Mer Antibody
By Anonymous on 11/08/2022
Application: WB Sample Tested: lysates of primary bone marrow derived macrophage Species: mice
Western Blot Mouse Mer Antibody AF591
Mouse Mer Antibody
By Anonymous on 06/17/2017
Application: Flow Sample Tested: Peritoneal macrophages Species: Mouse