Mouse Luminex® Discovery Assay
Build your own Luminex Assay with our Luminex Assay Customization Tool.
U.S. orders usually ship in 7-10 business days
Build NowMouse Luminex® Discovery Assay Summary
Assay Type | Magnetic bead-based multiplex assay for the Luminex® platform |
Format | 1 x 96-well microplate and Magnetic antibody-coated beads |
Species | Mouse |
Analytes Detected | Please see analyte list in assay customization tool below. |
Performance Validation | Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity. The mouse discovery Luminex Assay is also validated for use with tissue lysates. |
Make your selections below to configure your assay
Not finding your analyte of interest? View our complete Luminex offering in the full version of our Luminex Assay Ordering Tool. We also offer Custom Luminex Services
Magnetic Luminex Assays are the most flexible bead-based multiplex assays that we offer. They allow up to 50 user-defined target analytes to be simultaneously profiled using cell culture supernates, serum, or plasma samples.
- Simultaneously profile up to 50 analytes of your choice in one sample
- Choose from a wide menu of analytes, including many unique analytes
- Requires a small sample volume (<50 µL)
- Run your assay in just 3-4 hours
- Mass-calibrated standards for consistent results with every new lot of material
- Enough reagents for one 96-well plate
- Quick turn-around time: Kits are typically shipped within 5-10 days of ordering.*
Please allow additional time for international orders.
- Premixed cocktail of antibody-coated Magnetic beads
- Premixed cocktail of biotinylated detection antibody
- Standard Cocktail(s)
- Bead Diluent
- Biotin Antibody Diluent
- Standard/Sample Diluent
- Wash Buffer
- Streptavidin-PE
- One flat-bottom 96-well Microplate
- Foil Plate Sealers (4)
- Mixing Bottle
- Certificate of Analysis**
**A standard curve must be generated each time an assay is run, utilizing values from the Certificate of Analysis provided with each Luminex Assay.
Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.
Product Datasheets
Citations for Mouse Luminex® Discovery Assay
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Proton- compared to X-irradiation leads to more acinar atrophy and greater hyposalivation accompanied by a differential cytokine response
Authors: Juvkam, IS;Zlygosteva, O;Sitarz, M;Sørensen, BS;Aass, HCD;Edin, NJ;Galtung, HK;Søland, TM;Malinen, E;
Scientific reports
Species: Mouse
Sample Types: Serum, Saliva
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Lack of pathogenic involvement of CCL4 and its receptor CCR5 in arthritogenic alphavirus disease
Authors: Hameed, M;Solomon, NA;Weger-Lucarelli, J;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Serum
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Experimental Insights on the Use of Secukinumab and Magnolol in Acute Respiratory Diseases in Mice
Authors: Vicovan, AG;Petrescu, DC;Constantinescu, D;Iftimi, E;Cernescu, IT;Ancuta, CM;Carata?u, CC;?orodoc, L;Ceasovschih, A;Solcan, C;Ghiciuc, CM;
Biomedicines
Species: Mouse
Sample Types: Tissue Homogenates
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Resistant Starch-Encapsulated Probiotics Attenuate Colorectal Cancer Cachexia and 5-Fluorouracil-Induced Microbial Dysbiosis
Authors: Wang, JL;Chen, YS;Huang, KC;Yeh, CH;Chen, MC;Wu, LS;Chiu, YH;
Biomedicines
Species: Mouse
Sample Types: Tissue Homogenates
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Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma.
Authors: Barry, M;Trivedi, A;Miyazawa, B;Vivona, LR;Shimmin, D;Pathipati, P;Keane, C;Cuschieri, J;Pati, S;
Journal of translational medicine
Species: Mouse
Sample Types: Plasma
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Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way
Authors: Cao, Z;Wang, J;Liu, X;Liu, Y;Li, F;Liu, M;Chiu, S;Jin, X;
mBio
Species: Mouse
Sample Types: Serum
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Nutrient availability regulates the secretion and function of immune cell-derived extracellular vesicles through metabolic rewiring
Authors: Wang, Y;Lou, P;Xie, Y;Liu, S;Li, L;Wang, C;Du, D;Chen, Y;Lu, Y;Cheng, J;Liu, J;
Science advances
Species: Mouse
Sample Types: Cell Culture Supernates
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Tirzepatide attenuates mammary tumor progression in diet-induced obese mice
Authors: Glenny, EM;Ho, AN;Kiesel, VA;Chen, F;Gates, CE;Paules, EM;Xu, R;Holt, CA;Coleman, MF;Hursting, SD;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Serum
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Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis
Authors: Bourayou, E;Perchet, T;Meunier, S;Bouvier, H;Mailhe, MP;Melanitou, E;Cumano, A;Golub, R;
Cell reports
Species: Mouse
Sample Types: Cell Culture Supernates
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Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury
Authors: Jeon, J;Lee, K;Jang, HR;Yang, KE;Lee, CJ;Ahn, H;Park, WY;Lee, JE;Kwon, GY;Kim, YG;Huh, W;
Scientific reports
Species: Mouse
Sample Types: Tissue Homogenates
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Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice
Authors: Xu, G;Chen, H;Cong, Z;Wang, R;Li, X;Xie, Y;Wang, Y;Li, B;
The Journal of nutritional biochemistry
Species: Mouse
Sample Types: Serum
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EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors
Authors: Li, D;Guo, X;Yang, K;Yang, Y;Zhou, W;Huang, Y;Liang, X;Su, J;Jiang, L;Li, J;Fu, M;He, H;Yang, J;Shi, H;Yang, H;Tong, A;Chen, N;Hu, J;Xu, Q;Wei, YQ;Wang, W;
Science advances
Species: Mouse
Sample Types: Serum
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Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections
Authors: Abberger, H;Hose, M;Ninnemann, A;Menne, C;Eilbrecht, M;Lang, KS;Matuschewski, K;Geffers, R;Herz, J;Buer, J;Westendorf, AM;Hansen, W;
PLoS pathogens
Species: Mouse
Sample Types: Cell Culture Supernates
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Comparison of the Immunogenicity and Efficacy of rBCG-EPCP009, BCG Prime-EPCP009 Booster, and EPCP009 Protein Regimens as Tuberculosis Vaccine Candidates
Authors: Wang, R;Fan, X;Xu, D;Li, M;Zhao, X;Cao, B;Qian, C;Yu, J;Fang, D;Gu, Y;Wan, K;Liu, H;
Vaccines
Species: Mouse
Sample Types: Cell Culture Supernates
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Mesenchymal Stromal Cells Primed by Toll-like Receptors 3 and 4 Enhanced Anti-Inflammatory Effects against LPS-Induced Macrophages via Extracellular Vesicles
Authors: Hwang, S;Sung, DK;Kim, YE;Yang, M;Ahn, SY;Sung, SI;Chang, YS;
International journal of molecular sciences
Species: Mouse
Sample Types: Cell Culture Supernates
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Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection
Authors: Griffith, JW;Faustino, LD;Cottrell, VI;Nepal, K;Hariri, LP;Chiu, RS;Jones, MC;Julé, A;Gabay, C;Luster, AD;
Nature immunology
Species: Mouse
Sample Types: BALF
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Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer
Authors: Hughson, AL;Hannon, G;Salama, NA;Vrooman, TG;Stockwell, CA;Mills, BN;Garrett-Larsen, J;Qiu, H;Katerji, R;Benoodt, L;Johnston, CJ;Murphy, JD;Kruger, E;Ye, J;Gavras, NW;Keeley, DC;Qin, SS;Lesch, ML;Muhitch, JB;Love, TMT;Calvi, LM;Lord, EM;Luheshi, N;Elyes, J;Linehan, DC;Gerber, SA;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Tissue Homogenates
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Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge
Authors: Weaver, KL;Bitzer, GJ;Wolf, MA;Pyles, GM;DeJong, MA;Dublin, SR;Huckaby, AB;Gutierrez, MP;Hall, JM;Wong, TY;Warden, M;Petty, JE;Witt, WT;Cunningham, C;Sen-Kilic, E;Damron, FH;Barbier, M;
PloS one
Species: Mouse
Sample Types: Tissue Homogenates
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Cytokine Levels in Saliva Are Associated with Salivary Gland Fibrosis and Hyposalivation in Mice after Fractionated Radiotherapy of the Head and Neck
Authors: Zlygosteva, O;Juvkam, IS;Aass, HCD;Galtung, HK;Søland, TM;Malinen, E;Edin, NFJ;
International journal of molecular sciences
Species: Mouse
Sample Types: Serum, Saliva
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Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging
Authors: Corraliza-Gomez, M;Bermejo, T;Lilue, J;Rodriguez-Iglesias, N;Valero, J;Cozar-Castellano, I;Arranz, E;Sanchez, D;Ganfornina, MD;
Journal of neuroinflammation
Species: Transgenic Mouse, Mouse
Sample Types: Cell Culture Supernates
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Epigallocatechin Gallate-Modified Silver Nanoparticles Show Antiviral Activity against Herpes Simplex Type 1 and 2
Authors: Krzyzowska, M;Janicka, M;Chodkowski, M;Patrycy, M;Obuch-Woszczaty?ska, O;Tomaszewska, E;Ranoszek-Soliwoda, K;Celichowski, G;Grobelny, J;
Viruses
Species: Mouse
Sample Types: Vaginal Lavage Fluid
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Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation
Authors: Markezana, A;Paldor, M;Liao, H;Ahmed, M;Zorde-Khvalevsky, E;Rozenblum, N;Stechele, M;Salvermoser, L;Laville, F;Goldmann, S;Rosenberg, N;Andrasina, T;Ricke, J;Galun, E;Goldberg, SN;
Scientific reports
Species: Mouse
Sample Types: Plasma
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Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer
Authors: Camp, K;Coleman, MF;McFarlane, T;Doerstling, SS;Khatib, SA;Rezeli, ET;Lewis, AG;Pfeil, AJ;Smith, LA;Bowers, LW;Fouladi, F;Gong, W;Glenny, EM;Parker, JS;Milne, GL;Carroll, IM;Fodor, AA;Seeley, RJ;Hursting, SD;
JCI insight
Species: Mouse
Sample Types: Serum
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Regulation of IGF1R by MicroRNA-15b Contributes to the Anticancer Effects of Calorie Restriction in a Murine C3-TAg Model of Triple-Negative Breast Cancer
Authors: Bustamante-Marin, X;Devlin, KL;McDonell, SB;Dave, O;Merlino, JL;Grindstaff, EJ;Ho, AN;Rezeli, ET;Coleman, MF;Hursting, SD;
Cancers
Species: Mouse
Sample Types: Serum
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miR-378 influences muscle satellite cells and enhances adipogenic potential of fibro-adipogenic progenitors but does not affect muscle regeneration in the glycerol-induced injury model
Authors: Mucha, O;Podkalicka, P;?ukowska, M;Po?piech, E;Dulak, J;?oboda, A;
Scientific reports
Species: Mouse
Sample Types: Tissue Homogenates
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Lower female survival from an opportunistic infection reveals progesterone-driven sex bias in trained immunity
Authors: Earhart, AP;Karasseva, NG;Storey, KM;Olthoff, B;Sarker, MB;Laffey, KG;Lange, MJ;Rector, RS;Schulz, LC;Gil, D;Neuhauser, CM;Schrum, AG;
Cell reports
Species: Mouse
Sample Types: Cell Culture Supernates
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Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-?B pathway in Crohn's disease
Authors: Zhou, L;Zhu, L;Wu, X;Hu, S;Zhang, S;Ning, M;Yu, J;Chen, M;
BMC medicine
Species: Mouse
Sample Types: Serum
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Expression conditions and characterization of a novelly-constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections
Authors: Kaur, R;Mangiafesto, J;Pryharski, K;Rasam, S;Zagursky, R;Pichichero, M;
The Journal of biological chemistry
Species: Mouse
Sample Types: Serum
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Authors: Zhang, T;Xu, D;Liu, J;Wang, M;Duan, LJ;Liu, M;Meng, H;Zhuang, Y;Wang, H;Wang, Y;Lv, M;Zhang, Z;Hu, J;Shi, L;Guo, R;Xie, X;Liu, H;Erickson, E;Wang, Y;Yu, W;Dang, F;Guan, D;Jiang, C;Dai, X;Inuzuka, H;Yan, P;Wang, J;Babuta, M;Lian, G;Tu, Z;Miao, J;Szabo, G;Fong, GH;Karnoub, AE;Lee, YR;Pan, L;Kaelin, WG;Yuan, J;Wei, W;
Nature cell biology
Species: Mouse
Sample Types: Serum
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Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells
Authors: Jadi, PK;Dave, A;Issa, R;Tabbasum, K;Okurowska, K;Samarth, A;Urwin, L;Green, LR;Partridge, LJ;MacNeil, S;Garg, P;Monk, PN;Roy, S;
The ocular surface
Species: Mouse
Sample Types: Tissue Homogenates
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Effects of R-salbutamol on the inflammatory response and acute lung injury in endotoxemic mice
Authors: Beng, H;Hu, J;Wang, S;Liang, X;Qin, H;Tan, W;
International immunopharmacology
Species: Mouse
Sample Types: Serum
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IL-6 and TGF-?-Secreting Adoptively-Transferred Murine Mesenchymal Stromal Cells Accelerate Healing of Psoriasis-like Skin Inflammation and Upregulate IL-17A and TGF-?
Authors: Cuesta-Gomez, N;Medina-Ruiz, L;Graham, GJ;Campbell, JDM;
International journal of molecular sciences
Species: Mouse
Sample Types: Cell Culture Supernates
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Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle
Authors: Nasir, NJM;Heemskerk, H;Jenkins, J;Hamadee, NH;Bunte, R;Tucker-Kellogg, L;
eLife
Species: Mouse
Sample Types: Tissue Homogenates
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses
Authors: Heuberger, CE;Janney, A;Ilott, N;Bertocchi, A;Pott, S;Gu, Y;Pohin, M;Friedrich, M;Mann, EH;Pearson, C;Powrie, FM;Pott, J;Thornton, E;Maloy, KJ;
Mucosal immunology
Species: Transgenic Mouse
Sample Types: Cell Culture Supernates
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Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
Authors: Gullotta, GS;De Feo, D;Friebel, E;Semerano, A;Scotti, GM;Bergamaschi, A;Butti, E;Brambilla, E;Genchi, A;Capotondo, A;Gallizioli, M;Coviello, S;Piccoli, M;Vigo, T;Della Valle, P;Ronchi, P;Comi, G;D'Angelo, A;Maugeri, N;Roveri, L;Uccelli, A;Becher, B;Martino, G;Bacigaluppi, M;
Nature immunology
Species: Mouse
Sample Types: Plasma
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Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma
Authors: W�jcik-Pszczo?a, K;Pociecha, K;Ch?o?-Rzepa, G;Zadro?na, M;Nowak, B;Plutecka, H;Koczurkiewicz-Adamczyk, P;Przejczowska-Pomierny, K;P?kala, E;Gosens, R;Wyska, E;
International immunopharmacology
Species: Mouse
Sample Types: BALF
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Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction
Authors: D Sawaki, Y Zhang, A Mohamadi, M Pini, Z Mezdari, L Lipskaia, S Naushad, L Lamendour, DM Altintas, M Breau, H Liang, M Halfaoui, T Delmont, M Surenaud, D Rousseau, T Yoshimitsu, F Louache, S Adnot, C Henegar, P Gual, G Czibik, G Derumeaux
JCI Insight, 2023-04-24;8(8):.
Species: Mouse
Sample Types: Plasma
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The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation
Authors: IA von Mücke-, J Martin, M Uhr, C Ries, JM Deussing
Frontiers in Pharmacology, 2023-04-10;14(0):1148190.
Species: Mouse
Sample Types: Cell Culture Supernates
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A Multistage Antigen Complex Epera013 Promotes Efficient and Comprehensive Immune Responses in BALB/c Mice
Authors: C Qian, X Fan, R Wang, B Cao, J Yu, X Luan, G Li, Y Jiang, M Li, X Zhao, D Fang, K Wan, H Liu, Y Lou
Vaccines, 2023-03-07;11(3):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages
Authors: C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu
Journal of Neuroinflammation, 2023-02-23;20(1):45.
Species: Mouse
Sample Types: Cell Culture Supernates
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Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population
Authors: JD Morel, MB Sleiman, TY Li, G von Alvens, AM Bachmann, D Hofer, E Broeckx, JY Ma, V Carreira, T Chen, N Azhar, RA Gonzalez-V, M Breyer, D Reilly, S Mullican, J Auwerx
JCI Insight, 2023-02-08;8(3):.
Species: Mouse
Sample Types: Plasma
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Mono-ADP-ribosyltransferase 1 ( Artc1 )-deficiency decreases tumorigenesis, increases inflammation, decreases cardiac contractility, and reduces survival
Authors: H Ishiwata-E, J Kato, H Oda, J Sun, ZX Yu, C Liu, DA Springer, P Dagur, MJ Lizak, E Murphy, J Moss
bioRxiv : the preprint server for biology, 2023-02-06;0(0):.
Species: Mouse
Sample Types: Plasma
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Akkermansia muciniphila Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice
Authors: Y Xu, J Duan, D Wang, J Liu, X Chen, XY Qin, W Yu
Metabolites, 2023-01-28;13(2):.
Species: Mouse
Sample Types: Serum
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Timing and cell specificity of senescence drives postnatal lung development and injury
Authors: H Yao, J Wallace, AL Peterson, A Scaffa, S Rizal, K Hegarty, H Maeda, JL Chang, N Oulhen, JA Kreiling, KE Huntington, ME De Paepe, G Barbosa, PA Dennery
Nature Communications, 2023-01-17;14(1):273.
Species: Mouse
Sample Types: Cell Culture Supernates
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Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses
Authors: Q Zhou, Y Luo, Y Zhu, Q Chen, J Qiu, F Cong, Y Li, X Zhang
European Journal of Medicinal Chemistry, 2023-01-10;249(0):115113.
Species: Mouse
Sample Types: Tissue Homogenates
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Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Authors: V Mattioda, V Benedetti, C Tessarolo, F Oberto, A Favole, M Gallo, W Martelli, MI Crescio, E Berio, L Masoero, A Benedetto, M Pezzolato, E Bozzetta, C Grattarola, C Casalone, C Corona, F Giorda
Biomolecules, 2023-01-10;13(1):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer
Authors: YC Huang, CY Chang, YY Wu, KL Wu, YM Tsai, HC Lee, EM Tsai, YL Hsu
Cancers, 2022-12-28;15(1):.
Species: Transgenic Mouse
Sample Types: Cell Culture Supernates
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Involvement of miRNA-34a regulated Kr�ppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells
Authors: H Maeda, H Yao, H Go, KE Huntington, ME De Paepe, PA Dennery
Respiratory Research, 2022-12-10;23(1):340.
Species: Mouse
Sample Types: Cell Culture Supernates
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p21 induces a senescence program and skeletal muscle dysfunction
Authors: DA Englund, A Jolliffe, Z Aversa, X Zhang, I Sturmlechn, AE Sakamoto, JD Zeidler, GM Warner, C McNinch, TA White, EN Chini, DJ Baker, JM van Deurse, NK LeBrasseur
Molecular Metabolism, 2022-12-09;67(0):101652.
Species: Mouse
Sample Types: Plasma
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Molecular, cellular and neurological consequences of infection by the neglected human pathogen Nocardia
Authors: X Ji, L Han, W Zhang, L Sun, S Xu, X Qiu, S Fan, Z Li
Bmc Biology, 2022-11-09;20(1):251.
Species: Mouse
Sample Types: Tissue Homogenates
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Molecular and Cellular Markers in Chlorhexidine-Induced Peritoneal Fibrosis in Mice
Authors: N Brezovec, N Kojc, A Erman, M Hladnik, J Stergar, M Milani?, M Tomši?, S ?u?nik, S Sodin-Šemr, M Perše, K Lakota
Biomedicines, 2022-10-27;10(11):.
Species: Mouse
Sample Types: Serum
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Chicken IgY reduces the risk of Pseudomonas aeruginosa urinary tract infections in a murine model
Authors: FA Schwartz, L Christophe, K Thomsen, S Baekdal, M Pals Bendi, M Jørgensen, IK Bull Rasmu, AS Laulund, N Høiby, C Moser
Frontiers in Microbiology, 2022-09-09;13(0):988386.
Species: Mouse
Sample Types: Tissue Homogenates
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Potential Health-Promoting Effects of Two Candidate Probiotics Isolated from Infant Feces Using an Immune-Based Screening Strategy
Authors: H Liang, X Ze, S Wang, Y Wang, C Peng, R Cheng, F Jiang, S Wu, R He, F He, X Zhang, X Shen
Nutrients, 2022-09-03;14(17):.
Species: Mouse
Sample Types: Serum
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Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis
Authors: M Kondo, T Suzuki, Y Kawano, S Kojima, M Miyashiro, A Matsumoto, G Kania, P B?yszczuk, RL Ross, P Mulipa, F Del Galdo, Y Zhang, JHW Distler
Arthritis Research & Therapy, 2022-09-01;24(1):210.
Species: Mouse
Sample Types: Serum
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Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Authors: DC Humphries, R Mills, C Boz, BJ McHugh, N Hirani, AG Rossi, A Pedersen, HT Schambye, RJ Slack, H Leffler, UJ Nilsson, W Wang, T Sethi, AC Mackinnon
Frontiers in Pharmacology, 2022-08-08;13(0):949264.
Species: Mouse
Sample Types: BALF
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Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis
Authors: L Li, J Freitag, C Asbrand, B Munteanu, BT Wang, E Zezina, M Didier, G Thill, C Rocher, M Herrmann, N Biesemann
Scientific Reports, 2022-07-12;12(1):11830.
Species: Mouse
Sample Types: Plasma
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Targeting IL-1beta as an immune preventive and therapeutic modality for K-ras mutant lung cancer
Authors: B Yuan, MJ Clowers, WV Velasco, S Peng, Q Peng, Y Shi, M Ramos-Cast, M Zarghooni, S Yang, RL Babcock, SH Chang, JV Heymach, J Zhang, EJ Ostrin, SS Watowich, H Kadara, SJ Moghaddam
JCI Insight, 2022-06-08;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity
Authors: CS Umeshappa, P Solé, J Yamanouchi, S Mohapatra, BGJ Surewaard, J Garnica, S Singha, D Mondal, E Cortés-Vic, C D'Mello, A Mason, P Kubes, P Serra, Y Yang, P Santamaria
Nature Communications, 2022-06-07;13(1):3279.
Species: Mouse
Sample Types: Cell Culture Supernates
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Integrative analysis of network pharmacology and proteomics to identify key targets of Tuomin-Zhiti-Decoction for allergic rhinitis
Authors: J Cheng, M Zhang, Y Zheng, J Wang, Q Wang
Oncogene, 2022-06-06;0(0):115448.
Species: Mouse
Sample Types: Serum
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Human Mesenchymal Stromal Cells Resolve Lipid Load in High Fat Diet-Induced Non-Alcoholic Steatohepatitis in Mice by Mitochondria Donation
Authors: S Nickel, M Christ, S Schmidt, J Kosacka, H Kühne, M Roderfeld, T Longerich, L Tietze, I Bosse, MJ Hsu, P Stock, E Roeb, B Christ
Cells, 2022-06-02;11(11):.
Species: Mouse
Sample Types: Tissue Homogenates
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DNA damage to beta cells in culture recapitulates features of senescent beta cells that accumulate in type 1 diabetes
Authors: G Brawerman, J Pipella, PJ Thompson
Molecular Metabolism, 2022-06-02;0(0):101524.
Species: Mouse
Sample Types: Cell Culture Supernates
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Metagenomic Analysis Reveals a Mitigating Role for Lactobacillus paracasei and Bifidobacterium animalis in Experimental Periodontitis
Authors: F Wu, B Fang, G Wuri, L Zhao, F Liu, M Zhang
Nutrients, 2022-05-19;14(10):.
Species: Mouse
Sample Types: Serum
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Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases
Authors: A ?wierczek, K Pociecha, H Plutecka, M ?lusarczyk, G Ch?o?-Rzep, E Wyska
Pharmaceutics, 2022-05-19;14(5):.
Species: Mouse
Sample Types: Serum
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Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response
Authors: EV Shmeleva, M Gomez de A, J Wagner, AJ Enright, AJ Macpherson, BJ Ferguson, GL Smith
PloS Pathogens, 2022-04-21;18(4):e1009854.
Species: Mouse
Sample Types: Tissue Homogenates
-
Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
Authors: C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu
Journal of Neuroinflammation, 2022-04-05;19(1):78.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Identification of gingerenone A as a novel senolytic compound
Authors: R Moaddel, M Rossi, S Rodriguez, R Munk, M Khadeer, K Abdelmohse, M Gorospe, L Ferrucci
PLoS ONE, 2022-03-29;17(3):e0266135.
Species: Mouse
Sample Types: Cell Lysates
-
Systemic and single cell level responses to 1�nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas
Authors: T Zhang, T Lei, R Yan, B Zhou, C Fan, Y Zhao, S Yao, H Pan, Y Chen, B Wu, Y Yang, L Hu, S Gu, X Chen, F Bao, Y Li, H Xie, R Tang, X Chen, Z Yin
Bioactive materials, 2022-03-26;18(0):199-212.
Species: Mouse
Sample Types: Serum
-
Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice
Authors: APV Sanches, JL de Oliveir, MS Ferreira, BS Lima, JÉ Miyamoto, LAP Simino, MA Torsoni, AS Torsoni, M Milanski, LM Ignácio-So
The Journal of nutritional biochemistry, 2022-03-03;0(0):108977.
Species: Mouse
Sample Types: Amniotic Fluid
-
Immune dysfunction induced by 2,6-dichloro-1,4-benzoquinone, an emerging water disinfection byproduct, due to the defects of host-microbiome interactions
Authors: J Wang, T Liu, L Liu, X Chen, X Zhang, H Du, C Wang, J Li, J Li
Chemosphere, 2022-01-28;294(0):133777.
Species: Mouse
Sample Types: Serum
-
Gammaherpesvirus Alters Alveolar Macrophages According to the Host Genetic Background and Promotes Beneficial Inflammatory Control over Pneumovirus Infection
Authors: G Gilliaux, D Desmecht
Viruses, 2022-01-06;14(1):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice
Authors: Y Wu, E Li, M Knight, G Adeniyi-Ip, LZ Song, AR Burns, AC Gazzinelli, R Fujiwara, ME Bottazzi, JE Weatherhea
PloS Neglected Tropical Diseases, 2021-12-16;15(12):e0010050.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies
Authors: J Chen, S Chen, J Chen, B Shen, Z Jiang, Y Xu
Frontiers in Pharmacology, 2021-12-14;12(0):770524.
Species: Mouse
Sample Types: Serum
-
Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid
Authors: MJ Eigenmann, TV Karlsen, M Wagner, O Tenstad, T Weinzierl, T Fauti, HP Grimm, T Skogstrand, C Klein, J Sam, P Umana, M Bacac, H Wiig, AC Walz
Pharmaceutics, 2021-12-07;13(12):.
Species: Mouse
Sample Types: Plasma
-
Effects of Importin alpha1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice
Authors: K Sakurai, T Itou, M Morita, E Kasahara, T Moriyama, T Macpherson, T Ozawa, Y Miyamoto, Y Yoneda, A Sekiyama, M Oka, T Hikida
PLoS ONE, 2021-11-12;16(11):e0258364.
Species: Mouse
Sample Types: Plasma
-
Effect of a Fiber D-Limonene-Enriched Food Supplement on Intestinal Microbiota and Metabolic Parameters of Mice on a High-Fat Diet
Authors: MC Valerii, S Turroni, C Ferreri, M Zaro, A Sansone, A Dalpiaz, G Botti, L Ferraro, R Spigarelli, I Bellocchio, F D'Amico, E Spisni
Pharmaceutics, 2021-10-21;13(11):.
Species: Mouse
Sample Types: Serum
-
Evaluation of a Murine Model for Testing Antimicrobial Implant Materials in the Blood Circulation System
Authors: C Moerke, M Kloss, K Wulf, S Illner, S Kischkel, M Sombetzki, N Grabow, E Reisinger, A Öner, H Ince
Biomedicines, 2021-10-13;9(10):.
Species: Mouse
Sample Types: Plasma
-
Adipose expression of CREB3L3 modulates body weight during obesity
Authors: MA McCann, Y Li, M Muñoz, V Gil, G Qiang, J Cordoba-Ch, M Blüher, S Duncan, CW Liew
Scientific Reports, 2021-09-29;11(1):19400.
Species: Mouse
Sample Types: Plasma
-
Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model
Authors: M Hafner, S Paukner, WW Wicha, B Hrva?i?, M Cedilak, I Faraho, SP Gelone
PLoS ONE, 2021-09-29;16(9):e0237659.
Species: Mouse
Sample Types: Tissue Homogenates
-
The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype
Authors: A Kiepura, K Stachyra, A Wi?niewska, K Ku?, K Czepiel, M Suski, M Ulatowska-, M Surmiak, R Olszanecki
International Journal of Molecular Sciences, 2021-09-09;22(18):.
Species: Mouse
Sample Types: Plasma
-
Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice
Authors: IY Abdelgawad, MKO Grant, FE Popescu, DA Largaespad, BN Zordoky
International Journal of Molecular Sciences, 2021-08-21;22(16):.
Species: Mouse
Sample Types: Serum
-
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
Authors: R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini
Nature Communications, 2021-07-27;12(1):4559.
Species: Mouse
Sample Types: Serum
-
Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity
Authors: IP Zavala-Gue, MS Ortega-Rom, J Narváez-Mo, TL Jacobo-Est, WK Lee, L Arreola-Me, F Thévenod, OC Barbier
International Journal of Molecular Sciences, 2021-07-06;22(14):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Serum amyloid A promotes inflammation-associated damage and tumourigenesis in a mouse model of colitis-associated cancer
Authors: TA Davis, D Conradie, P Shridas, FC de Beer, AM Engelbrech, WJS de Villier
Cellular and Molecular Gastroenterology and Hepatology, 2021-07-02;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Intralesional injection of rose bengal augments the efficacy of gemcitabine chemotherapy against pancreatic tumors
Authors: P Innamarato, J Morse, A Mackay, S Asby, M Beatty, J Blauvelt, S Kidd, JE Mullinax, AA Sarnaik, S Pilon-Thom
BMC Cancer, 2021-06-30;21(1):756.
Species: Mouse
Sample Types: Serum
-
The PI3K&delta inhibitor parsaclisib ameliorates pathology and reduces autoantibody formation in preclinical models of systemic lupus erythematosus and Sj?gren's syndrome
Authors: MD Scuron, BL Fay, AJ Connell, J Oliver, PA Smith
International immunopharmacology, 2021-06-29;98(0):107904.
Species: Mouse
Sample Types: Saliva
-
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
Authors: B Uyanik, AR Goloudina, A Akbarali, BB Grigorash, AV Petukhov, S Singhal, E Eruslanov, J Chaloyard, L Lagorgette, T Hadi, EV Baidyuk, H Sakai, L Tessarollo, B Ryffel, SJ Mazur, F Lirussi, C Garrido, E Appella, ON Demidov
Nature Communications, 2021-06-15;12(1):3622.
Species: Mouse
Sample Types: Tissue Homogenates
-
Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between beta-Catenin and NF-kappaB
Authors: J Jang, J Song, I Sim, YV Kwon, Y Yoon
International Journal of Molecular Sciences, 2021-06-10;22(12):.
Species: Mouse
Sample Types: Plasma
-
Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
Authors: YJ Bang, SH Hong, HJ Park, HW Kwak, YS Lee, JY Kim, HJ Park, SH Bae, HJ Kim, YH Kim, HL Ko, SI Park, H Kim, G Park, MS Park, J Chang, JH Nam
Scientific Reports, 2021-06-07;11(1):11981.
Species: Mouse
Sample Types: BALF
-
Author Correction: Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
Authors: LK Donovan, A Delaidelli, SK Joseph, K Bielamowic, K Fousek, BL Holgado, A Manno, D Srikanthan, AZ Gad, R Van Ommere, D Przelicki, C Richman, V Ramaswamy, C Daniels, JG Pallota, T Douglas, ACM Joynt, J Haapasalo, C Nor, MC Vladoiu, CM Kuzan-Fisc, L Garzia, SC Mack, S Varadharaj, ML Baker, L Hendrikse, M Ly, K Kharas, P Balin, X Wu, L Qin, N Huang, AG Stucklin, AS Morrissy, FMG Cavalli, B Luu, R Suarez, P De Antonel, A Michealraj, A Rastan, M Hegde, M Komosa, O Sirbu, SA Kumar, Z Abdullaev, CC Faria, S Yip, J Hukin, U Tabori, C Hawkins, K Aldape, M Daugaard, JM Maris, PH Sorensen, N Ahmed, MD Taylor
Nature Medicine, 2021-06-01;0(0):.
Species: Mouse
Sample Types: CSF
-
Mouse primary microglia respond differently to LPS and poly(I:C) in vitro
Authors: Y He, N Taylor, X Yao, A Bhattachar
Scientific Reports, 2021-05-17;11(1):10447.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Enhancing Cystic Fibrosis Immune Regulation
Authors: AM van Heecke, MT Sutton, DR Fletcher, CA Hodges, AI Caplan, TL Bonfield
Frontiers in Pharmacology, 2021-05-13;12(0):573065.
Species: Mouse
Sample Types: BALF
-
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model
Authors: SS Qin, BJ Han, A Williams, KM Jackson, R Jewell, AC Chacon, EM Lord, DC Linehan, M Kim, A Reuben, SA Gerber, PA Prieto
Cancers, 2021-05-11;13(10):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis
Authors: DH Zimmerman, K Mikecz, A Markovics, RE Carambula, JC Ciemielews, DM Toth, TT Glant, KS Rosenthal
Vaccines, 2021-05-02;9(5):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Regulation of Helicobacter-induced gastritis by programmed death ligand 1-expressing classical dendritic cells
Authors: DM Go, SH Lee, SH Lee, SH Woo, K Kim, K Kim, KS Park, JH Park, SJ Ha, WH Kim, JH Choi, DY Kim
Cellular and Molecular Gastroenterology and Hepatology, 2021-04-21;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses
Authors: JM Powers, NN Haese, M Denton, T Ando, C Kreklywich, K Bonin, CE Streblow, N Kreklywich, P Smith, R Broeckel, V DeFilippis, TE Morrison, MT Heise, DN Streblow
PloS Neglected Tropical Diseases, 2021-04-01;15(4):e0009308.
Species: Mouse
Sample Types: Tissue Homogenates
-
Neuromedin U Suppresses Collagen-Induced Arthritis through ILC2-Th2 Activation
Authors: Y Zhang, Y Qin, Z Chen
Journal of Immunology Research, 2021-03-08;2021(0):5599439.
Species: Mouse
Sample Types: Plasma
-
Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha
Authors: L Vasilikos, K Hänggi, LM Spilgies, S Kisele, S Rufli, WW Wong
Cancers, 2021-02-03;13(4):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response
Authors: SP Korpela, TK Hinz, A Oweida, J Kim, J Calhoun, R Ferris, RA Nemenoff, SD Karam, ET Clambey, LE Heasley
Journal of Translational Medicine, 2021-01-23;19(1):43.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease
Authors: Z Dwyer, M Chaiquin, J Landrigan, K Ayoub, P Shail, J Rocha, CL Childers, KB Storey, DJ Philpott, H Sun, S Hayley
Journal of Neuroinflammation, 2021-01-09;18(1):20.
Species: Mouse
Sample Types: Plasma
-
Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota
Authors: MR Park, M Shin, D Mun, SY Jeong, DY Jeong, M Song, G Ko, T Unno, Y Kim, S Oh
Scientific Reports, 2020-12-10;10(1):21701.
Species: Mouse
Sample Types: Serum
-
Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut-kidney axis
Authors: L Li, T Wei, S Liu, C Wang, M Zhao, Y Feng, L Ma, Y Lu, P Fu, J Liu
Journal of Cellular and Molecular Medicine, 2020-12-06;0(0):.
Species: Mouse
Sample Types: Serum
-
Shift work influences the outcomes of Chlamydia infection and pathogenesis
Authors: SR Lundy, S Richardson, A Ramsey, D Ellerson, Y Fengxia, S Onyeabor, W Kirlin, W Thompson, CM Black, JP DeBruyne, AJ Davidson, LC Immergluck, U Blas-Macha, FO Eko, JU Igietseme, Q He, YO Omosun
Scientific Reports, 2020-09-21;10(1):15389.
Species: Mouse
Sample Types: Vaginal Lavage
-
Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn's disease
Authors: L Allais, S Verschuere, T Maes, R De Smet, S Devriese, GB Gonzales, H Peeters, K Van Crombr, C Bachert, M De Vos, GG Brusselle, KR Bracke, CA Cuvelier, D Laukens
PLoS ONE, 2020-08-06;15(8):e0236657.
Species: Mouse
Sample Types: Tissue Homogenates
-
Marginal Zone Formation Requires ACKR3 Expression on B Cells
Authors: E Radice, R Ameti, S Melgrati, M Foglierini, P Antonello, RAK Stahl, S Thelen, D Jarrossay, M Thelen
Cell Rep, 2020-08-04;32(5):107951.
Species: Mouse
Sample Types: Cell Culture Supernates, Whole Cells
-
Loss of Osteopontin Expression Reduces HSV-1-Induced Corneal Opacity
Authors: A Filiberti, GB Gmyrek, ML Montgomery, R Sallack, DJJ Carr
Invest. Ophthalmol. Vis. Sci., 2020-08-03;61(10):24.
Species: Mouse
Sample Types: Tissue Homogenates
-
DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages
Authors: NA Pease, MS Shephard, M Sertorio, SE Waltz, LMP Vinnedge
Cancers (Basel), 2020-07-17;12(7):.
Species: Mouse
Sample Types: Tissue Culture Supernates
-
Epitope Shaving Promotes Fungal Immune Evasion
Authors: DS Childers, GM Avelar, JM Bain, A Pradhan, DE Larcombe, MG Netea, LP Erwig, NAR Gow, AJP Brown
MBio, 2020-07-07;11(4):.
Species: Mouse
Sample Types: Whole Blood
-
Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization
Authors: KW Kang, SJ Lee, JH Kim, BH Lee, SJ Kim, Y Park, BS Kim
BMC Cancer, 2020-07-02;20(1):619.
Species: Mouse
Sample Types: Plasma
-
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Authors: E Hadadi, W Taylor, XM Li, Y Aslan, M Villote, J Rivière, G Duvallet, C Auriau, S Dulong, I Raymond-Le, S Provot, A Bennaceur-, H Acloque
Nat Commun, 2020-06-24;11(1):3193.
Species: Mouse
Sample Types: Plasma
-
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
Authors: X Han, Y Lu, J Xie, E Zhang, H Zhu, H Du, K Wang, B Song, C Yang, Y Shi, Z Cao
Nat Nanotechnol, 2020-06-01;0(0):.
Species: Mouse
Sample Types: Serum
-
TGF-beta1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In�Vivo
Authors: K Lynch, O Treacy, X Chen, N Murphy, P Lohan, MN Islam, E Donohoe, MD Griffin, L Watson, S McLoughlin, G O'Malley, AE Ryan, T Ritter
Mol. Ther., 2020-05-30;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
Authors: D Lee, MK Ju, H Kim
Nutrients, 2020-05-19;12(5):.
Species: Mouse
Sample Types: Serum
-
Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination
Authors: EM Parzych, K Miura, CA Long, JM Burns
PLoS ONE, 2020-04-29;15(4):e0232355.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection
Authors: Q Zhang, J Hu, JW Feng, XT Hu, T Wang, WX Gong, K Huang, YX Guo, Z Zou, X Lin, R Zhou, YQ Yuan, AD Zhang, H Wei, G Cao, C Liu, LL Chen, ML Jin
Genome Biol., 2020-04-28;21(1):99.
Species: Mouse
Sample Types: Tissue Homogenates
-
Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer
Authors: MJ Bloom, AM Jarrett, TA Triplett, AK Syed, T Davis, TE Yankeelov, AG Sorace
BMC Cancer, 2020-04-28;20(1):359.
Species: Mouse
Sample Types: Cell Lysates
-
Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation
Authors: T Koopmans, L Hesse, MC Nawijn, K Kumawat, MH Menzen, I Sophie T B, R Smits, ERM Bakker, M van den Be, GH Koppelman, V Guryev, R Gosens
Sci Rep, 2020-04-21;10(1):6754.
Species: Mouse
Sample Types: Tissue Homogenates
-
Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability
Authors: S Ruiz, F Vardon-Bou, M Buléon, C Guilbeau-F, MH Séguelas, JM Conil, JP Girolami, I Tack, V Minville
J Transl Med, 2020-04-19;18(1):174.
Species: Mouse
Sample Types: Serum
-
A combination of genetics and microbiota influences the severity of the obesity phenotype in diet-induced obesity
Authors: M Smoczek, M Vital, D Wedekind, M Basic, NH Zschemisch, DH Pieper, A Siebert, A Bleich, M Buettner
Sci Rep, 2020-04-09;10(1):6118.
Species: Mouse
Sample Types: Serum
-
Exosome-based delivery of super-repressor I&kappaB&alpha relieves sepsis-associated organ damage and mortality
Authors: H Choi, Y Kim, A Mirzaaghas, J Heo, YN Kim, JH Shin, S Kim, NH Kim, ES Cho, J In Yook, TH Yoo, E Song, P Kim, EC Shin, K Chung, K Choi, C Choi
Sci Adv, 2020-04-08;6(15):eaaz6980.
Species: Mouse
Sample Types: Plasma
-
Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice
Authors: B Schirmer, T Rother, I Bruesch, A Bleich, C Werlein, D Jonigk, R Seifert, D Neumann
Cancers (Basel), 2020-04-08;12(4):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis
Authors: Z Shangxun, L Junjie, Z Wei, W Yutong, J Wenyuan, L Shanshou, W Yanjun, W Qianmei, F Zhusheng, Y Chaoping, Z Ran, Y Wen, H Yang
Mediators Inflamm., 2020-03-24;2020(0):9607535.
Species: Mouse
Sample Types: Serum
-
Inhibition of bone morphogenetic protein 6 receptors ameliorates Sj�gren's syndrome in mice
Authors: H Yin, L Kalra, Z Lai, MC Guimaro, L Aber, BM Warner, D Michael, N Zhang, J Cabrera-Pe, A Karim, WD Swaim, S Afione, A Voigt, CQ Nguyen, PB Yu, DB Bloch, JA Chiorini
Sci Rep, 2020-02-19;10(1):2967.
Species: Mouse
Sample Types: Serum
-
Muscle Injury Induces Postoperative Cognitive Dysfunction
Authors: L Guéniot, V Lepere, GF De Medeiro, A Danckaert, P Flamant, M Le Dudal, O Langeron, PL Goossens, F Chrétien, G Jouvion
Sci Rep, 2020-02-17;10(1):2768.
Species: Mouse
Sample Types: Tissue Homogenates
-
Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation
Authors: MKO Grant, IY Abdelgawad, CA Lewis, BN Zordoky
Int J Mol Sci, 2020-02-14;21(4):.
Species: Mouse
Sample Types: Serum
-
HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia
Authors: JR Huot, LJ Novinger, F Pin, A Bonetto
Dis Model Mech, 2020-01-24;0(0):.
Species: Mouse
Sample Types: Plasma
-
Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice
Authors: KS LeMessurie, AR Iverson, TC Chang, M Palipane, P Vogel, JW Rosch, AE Samarasing
Sci Rep, 2019-12-18;9(1):19360.
Species: Mouse
Sample Types: BALF
-
Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice
Authors: MC Simon, AL Reinbeck, C Wessel, J Heindirk, T Jelenik, K Kaul, J Arreguin-C, A Strom, M Blaut, F Bäckhed, V Burkart, M Roden
J. Biol. Chem., 2019-12-10;0(0):.
Species: Mouse
Sample Types: Serum
-
FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells
Authors: J Gimenes-Ju, N Owuar, HR Vari, W Li, N Xander, S Kotnala, US Sajjan
Sci Rep, 2019-12-03;9(1):18180.
Species: Mouse
Sample Types: BALF
-
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
Authors: T Delvaeye, MAJ De Smet, S Verwaerde, E Decrock, A Czekaj, RE Vandenbrou, K Lemeire, A Gonçalves, W Declercq, P Vandenabee, DV Krysko, L Leybaert
Sci Rep, 2019-11-12;9(1):16623.
Species: Mouse
Sample Types: Plasma
-
Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization
Authors: A Schulz, L Jiang, L de Vor, M Ehrström, F Wermeling, L Eidsmo, K Melican
Cell Rep, 2019-10-29;29(5):1074-1081.e5.
Species: Mouse
Sample Types: Tissue Homogenates
-
Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment
Authors: BN Mills, KA Connolly, J Ye, JD Murphy, TP Uccello, BJ Han, T Zhao, MG Drage, A Murthy, H Qiu, A Patel, NM Figueroa, CJ Johnston, PA Prieto, NK Egilmez, BA Belt, EM Lord, DC Linehan, SA Gerber
Cell Rep, 2019-10-08;29(2):406-421.e5.
Species: Mouse
Sample Types: Tissue Homogenates
-
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice
Authors: F Hempel, M Roderfeld, R Savai, A Sydykov, K Irungbam, R Schermuly, R Voswinckel, K Köhler, Y Churin, L Kiss, J Bier, J Pons-Kühne, E Roeb
Cells, 2019-10-07;8(10):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Authors: S Gooding, SWZ Olechnowic, EV Morris, AE Armitage, J Arezes, J Frost, E Repapi, JR Edwards, N Ashley, C Waugh, N Gray, E Martinez-H, PJ Lim, SR Pasricha, H Knowles, AJ Mead, K Ramasamy, H Drakesmith, CM Edwards
Nat Commun, 2019-10-04;10(1):4533.
Species: Mouse
Sample Types: Bone Marrow Plasma
-
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes
Authors: PJ Thompson, A Shah, H Apostolopo, A Bhushan
Int J Mol Sci, 2019-09-26;20(19):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Th1-biased immunoadjuvant effect of the recombinant B subunit of an Escherichia coli heat-labile enterotoxin on an inactivated PRRSV antigen via intranasal immunization in mice
Authors: F Su, L Xu, Y Xue, J Li, Y Fu, B Yu, S Wang, X Yuan
J. Vet. Med. Sci., 2019-09-16;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant
Authors: HJ Park, HL Ko, DH Won, DB Hwang, YS Shin, HW Kwak, HJ Kim, JW Yun, JH Nam
Pharmaceutics, 2019-09-07;11(9):.
Species: Mouse
Sample Types: Serum
-
Performance of a glucose-reactive enzyme-based biofuel cell system for biomedical applications
Authors: WY Jeon, JH Lee, K Dashnyam, YB Choi, TH Kim, HH Lee, HW Kim, HH Kim
Sci Rep, 2019-07-26;9(1):10872.
Species: Mouse
Sample Types: Whole Cells
-
AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition
Authors: Y He, K Xu, Y Wang, X Chao, B Xu, J Wu, J Shen, W Ren, Y Hu
Exp. Gerontol., 2019-07-15;125(0):110661.
Species: Mouse
Sample Types: BALF
-
EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
Authors: M Swidergall, NV Solis, Z Wang, QT Phan, ME Marshall, MS Lionakis, E Pearlman, SG Filler
Cell Rep, 2019-07-09;28(2):423-433.e5.
Species: Mouse
Sample Types: Tissue Homogenates
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Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades
Authors: X Lu, Y Zhu, R Bai, Z Wu, W Qian, L Yang, R Cai, H Yan, T Li, V Pandey, Y Liu, PE Lobie, C Chen, T Zhu
Nat Nanotechnol, 2019-06-24;14(7):719-727.
Species: Mouse
Sample Types: BALF
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Depletion of Intestinal Microbiome Partially Rescues Bone Loss in Sickle Cell Disease Male Mice
Authors: S Tavakoli, L Xiao
Sci Rep, 2019-06-17;9(1):8659.
Species: Mouse
Sample Types: Serum
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Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
Authors: C Rudyk, Z Dwyer, S Hayley
J Neuroinflammation, 2019-06-07;16(1):120.
Species: Mouse, Transgenic Mouse
Sample Types: Plasma
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The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer
Authors: E Pastille, MH Wasmer, A Adamczyk, VP Vu, LF Mager, NNT Phuong, V Palmieri, C Simillion, W Hansen, S Kasper, M Schuler, B Muggli, KD McCoy, J Buer, I Zlobec, AM Westendorf, P Krebs
Mucosal Immunol, 2019-06-05;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: Tissue Culture Supernates
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Correlation network analysis shows divergent effects of a long-term, high-fat diet and exercise on early stage osteoarthritis phenotypes in mice
Authors: TM Griffin, A Batushansk, J Hudson, EBP Lopes
J Sport Health Sci, 2019-05-24;9(2):119-131.
Species: Mouse
Sample Types: Serum
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Papaver nudicaule (Iceland poppy) alleviates lipopolysaccharide-induced inflammation through inactivating NF-?B and STAT3
Authors: JH Oh, M Yun, D Park, IJ Ha, CK Kim, DW Kim, EO Kim, SG Lee
BMC Complement Altern Med, 2019-04-29;19(1):90.
Species: Mouse
Sample Types: Cell Culture Supernates
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Adipose Tissue Regulates Pulmonary Pathology during TB Infection
Authors: JP Ayyappan, U Ganapathi, K Lizardo, C Vinnard, S Subbian, D Perlin, JF Nagajyothi
MBio, 2019-04-16;10(2):.
Species: Mouse
Sample Types: Serum
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Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense
Authors: CP Parlet, JS Kavanaugh, HA Crosby, HA Raja, T El-Elimat, DA Todd, CJ Pearce, NB Cech, NH Oberlies, AR Horswill
Cell Rep, 2019-04-02;27(1):187-198.e6.
Species: Mouse
Sample Types: Tissue Homogenates
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Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust
Authors: KJ Warren, JD Dickinson, AJ Nelson, TA Wyatt, DJ Romberger, JA Poole
Respir. Res., 2019-03-07;20(1):51.
Species: Mouse
Sample Types: BALF
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Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice
Authors: SD Hwang, JH Song, Y Kim, JH Lim, MY Kim, EN Kim, YA Hong, S Chung, BS Choi, YS Kim, CW Park
Cell Death Dis, 2019-03-04;10(3):219.
Species: Mouse
Sample Types: Serum
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Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood
Authors: R Cheng, J Guo, F Pu, C Wan, L Shi, H Li, Y Yang, C Huang, M Li, F He
Sci Rep, 2019-03-01;9(1):3254.
Species: Mouse
Sample Types: Serum
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Physiology and effects of nucleosides in mice lacking all four adenosine receptors
Authors: C Xiao, N Liu, KA Jacobson, O Gavrilova, ML Reitman
PLoS Biol., 2019-03-01;17(3):e3000161.
Species: Mouse
Sample Types: Plasma
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A novel, multiple-antigen pneumococcal vaccine protects against lethal Streptococcus pneumoniae challenge
Authors: WY Chan, C Entwisle, G Ercoli, E Ramos-Sevi, A McIlgorm, P Cecchini, C Bailey, O Lam, G Whiting, N Green, D Goldblatt, JX Wheeler, JS Brown
Infect. Immun., 2019-02-21;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB
Authors: YL Hsu, MC Yen, WA Chang, PH Tsai, YC Pan, SH Liao, PL Kuo
Breast Cancer Res., 2019-02-12;21(1):23.
Species: Mouse
Sample Types: Cell Culture Supernates
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Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model
Authors: H Furuya, OTM Chan, I Pagano, C Zhu, N Kim, R Peres, K Hokutan, S Alter, P Rhode, CJ Rosser
J Transl Med, 2019-01-17;17(1):29.
Species: Mouse
Sample Types: Urine
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The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation
Authors: D Liu, T Li, H Luo, X Zuo, S Liu, S Wu
Arthritis Res. Ther., 2018-11-28;20(1):263.
Species: Mouse
Sample Types:
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The Interaction of miR-378i-Skp2 Regulates Cell Senescence in Diabetic Nephropathy
Authors: YC Tsai, PL Kuo, MC Kuo, WW Hung, LY Wu, WA Chang, PH Wu, SC Lee, HC Chen, YL Hsu
J Clin Med, 2018-11-22;7(12):.
Species: Mouse
Sample Types: Urine
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Systemic vascular leakage induced in mice by Russell's viper venom from Pakistan
Authors: A Rucavado, T Escalante, E Camacho, JM Gutiérrez, JW Fox
Sci Rep, 2018-10-31;8(1):16088.
Species: Mouse
Sample Types: Plasma
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Lack of vitamin D signalling per se does not aggravate cardiac functional impairment induced by myocardial infarction in mice
Authors: K Ford, N Latic, S Slavic, U Zeitz, M Dolezal, O Andrukhov, RG Erben, O Andrukhova
PLoS ONE, 2018-10-01;13(10):e0204803.
Species: Mouse
Sample Types: Serum
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A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice
Authors: AD Griffith, AK Zaidi, A Pietro, M Hadiono, JS Yang, R Davis, DL Popkin
Sci Rep, 2018-09-27;8(1):14451.
Species: Mouse
Sample Types: Plasma
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4-1BB enhancement of CAR T function requires NF-?B and TRAFs
Authors: G Li, JC Boucher, H Kotani, K Park, Y Zhang, B Shrestha, X Wang, L Guan, N Beatty, D Abate-Daga, ML Davila
JCI Insight, 2018-09-20;3(18):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Prophylactic efficacy of orally administered Bacillus poly-?-glutamic acid, a non-LPS TLR4 ligand, against norovirus infection in mice
Authors: W Lee, M Kim, SH Lee, HG Jung, JW Oh
Sci Rep, 2018-06-06;8(1):8667.
Species: Mouse
Sample Types: Serum
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RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells
Authors: Y He, X Yao, N Taylor, Y Bai, T Lovenberg, A Bhattachar
J Neuroinflammation, 2018-05-22;15(1):153.
Species: Mouse
Sample Types: Cell Culture Supernates
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Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
Authors: KS LeMessurie, M Palipane, M Tiwary, B Gavin, AE Samarasing
Sci Rep, 2018-05-04;8(1):7061.
Species: Mouse
Sample Types: Tissue Homogenates
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Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3
Authors: TB Kang, JS Jeong, SH Yang, A Kovalenko, D Wallach
Cell Death Differ., 2018-04-17;0(0):.
Species: Mouse
Sample Types: Plasma
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Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury
Authors: BH Kim, HW Jung, SH Seo, H Shin, J Kwon, JM Suh
Cell Death Dis, 2018-03-07;9(3):383.
Species: Mouse
Sample Types: Serum
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Leptin Signaling Mediates Obesity-associated CSC Enrichment and EMT in Preclinical TNBC Models
Authors: LW Bowers, EL Rossi, SB McDonell, SS Doerstling, SA Khatib, CG Lineberger, JE Albright, X Tang, LA deGraffenr, SD Hursting
Mol. Cancer Res., 2018-02-16;0(0):.
Species: Mouse
Sample Types: Serum
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Serum amyloid A3 is required for normal weight and immunometabolic function in mice
Authors: JL Ather, ME Poynter
PLoS ONE, 2018-02-01;13(2):e0192352.
Species: Mouse
Sample Types: Cell Culture Supernates
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Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma
Authors: JK Thompson, A Shukla, AL Leggett, PB Munson, JM Miller, MB MacPherson, SL Beuschel, HI Pass, A Shukla
Oncotarget, 2017-12-06;9(1):293-305.
Species: Mouse
Sample Types: Peritoneal Lavage Fluid
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CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation
Authors: J Deng, ES Wang, RW Jenkins, S Li, R Dries, K Yates, S Chhabra, W Huang, H Liu, AR Aref, E Ivanova, CP Paweletz, M Bowden, CW Zhou, GS Herter-Spr, JA Sorrentino, JE Bisi, PH Lizotte, AA Merlino, MM Quinn, LE Bufe, A Yang, Y Zhang, H Zhang, P Gao, T Chen, ME Cavanaugh, AJ Rode, E Haines, PJ Roberts, JC Strum, WG Richards, JH Lorch, S Parangi, V Gunda, GM Boland, R Bueno, S Palakurthi, GJ Freeman, J Ritz, WN Haining, NE Sharpless, H Arthanari, GI Shapiro, DA Barbie, NS Gray, KK Wong
Cancer Discov, 2017-11-03;0(0):.
Species: Transgenic Mouse
Sample Types: BALF
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The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice
Authors: L Böhm, S Torsin, SH Tint, MT Eckstein, T Ludwig, JC Pérez
PLoS Pathog., 2017-10-25;13(10):e1006699.
Species: Mouse
Sample Types: Tissue Homogenates
-
Lactobacillus paracasei feeding improves immune control of influenza infection in mice
Authors: N Belkacem, N Serafini, R Wheeler, M Derrien, L Boucinha, A Couesnon, N Cerf-Bensu, I Gomperts B, JP Di Santo, MK Taha, R Bourdet-Si
PLoS ONE, 2017-09-20;12(9):e0184976.
Species: Mouse
Sample Types: Tissue Homogenates
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Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice
Authors: EJ Wunschel, B Schirmer, R Seifert, D Neumann
Front Pharmacol, 2017-09-13;8(0):642.
Species: Mouse
Sample Types: Tissue Homogenates
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Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia
Authors: TS Kapellos, C Recio, DR Greaves, AJ Iqbal
Mediators Inflamm., 2017-08-09;2017(0):4315412.
Species: Mouse
Sample Types: Serum
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Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease
Authors: SFH de Witte, AM Merino, M Franquesa, T Strini, JAA van Zoggel, SS Korevaar, F Luk, M Gargesha, L O'Flynn, D Roy, SJ Elliman, PN Newsome, CC Baan, MJ Hoogduijn
Stem Cell Res Ther, 2017-06-08;8(1):140.
Species: Mouse
Sample Types: Serum
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Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model
J Cancer, 2016-12-09;7(15):2378-2387.
Species: Mouse
Sample Types: Plasma
-
Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII
Authors: Ingrid Stroo
Am. J. Physiol. Lung Cell Mol. Physiol, 2016-12-02;0(0):ajplung.00320.
Species: Mouse
Sample Types: Tissue Homogenates
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Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland
Authors: Gerard J Graham
Development, 2016-11-25;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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Complement Component 3 Regulates IFN-? Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle
Authors: Alain Lamarre
J. Immunol., 2016-11-18;0(0):.
Species: Mouse
Sample Types: Serum
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Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas
Int J Cancer, 2016-08-29;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice
Authors: JC Gomez, H Dang, JR Martin, CM Doerschuk
J. Immunol, 2016-08-26;197(7):2864-79.
Species: Mouse
Sample Types: BALF
-
CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
Authors: Daniel Hsu
Infect Immun, 2016-08-19;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
Nat Commun, 2016-07-29;7(0):12304.
Species: Mouse
Sample Types: Serum
FAQs
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Are QC controls available for both the Luminex Discovery and High Performance Assays?
Controls are not offered for Luminex Discovery Assays, but may be formulated by the end user. A general guide may be available upon request. Controls are available for select Luminex High Performance Assays and can be found under the supplemental products tab on the product webpage. Some High Performance Luminex kits include controls and the controls will be listed in the materials provided section on the product datasheet. When included in the kit, controls are not sold separately.
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Can this assay be used for analysis of tissue homogenates?
This assay has been validated for use with tissue lysates, and a protocol is noted in the product insert for preparation of the tissue lysate. The assay has not been validated for use with tissue homogenates. In order to validate tissue homogenate for this assay, a good starting point would be homogenizing in a non-denaturing buffer with protease inhibitors. We recommend validating this sample type with Spike/Recovery and Linearity testing. Please contact Technical Support at techsupport@bio-techne.com with additional questions.
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What is the reason for the recommendation to use 35 µL sample volume, instead of the default 50 µL volume, for Luminex multiplex containing > 25 analytes, when assayed on Luminex MAGPIX® analyzer?
R&D Systems recommend 35 µL sample volume for > 25 analytes to control the number of beads in the sample load when using Luminex MAGPIX® analyzer. Luminex MAGPIX® analyzer is a non-flow-based reader which utilizes a magnet to hold the magnetic microparticles in a monolayer in a chamber where the beads are imaged and then processed by the software to generate data. Since MAGPIX® system pushes the entire Sample Load Volume into the chamber, multiplex assay containing > 25 analytes may overload the chamber capacity with 50 µL sample load default setting. The captured images can have too many beads in them to give accurate results, and some of the analytes/regions may present lower than desired bead counts.
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Does the Luminex Mouse Magnetic Assay detect soluble form or membrane-bound analyte?
The sample types typically validated by R&D Systems for Luminex assays contain soluble form of proteins, and therefore it is expected that the soluble form of proteins are detected. It is possible there are assays that also detect the membrane form of respective target proteins, however, R&D Systems does not generally evaluate our assays against samples known to contain membrane-bound proteins.
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Why does the Luminex Assay Customization Tool provide the option to split based on dilution?
The feature to split based on dilution enables investigators to configure premix Luminex panels based on sample type (cell culture supernates, serum, and plasma). This keeps analytes requiring the same dilution factor within a single panel, while separating analytes requiring different dilutions. The recommended dilution factor for each analyte may be different for each sample type, and the suggested sample dilutions are built into the Luminex Customization Tool. Note that the suggested dilution factors are based on samples from healthy volunteers.
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Is the reconstituted standard a concentrate?
For Discovery Assays, each standard cocktail is a concentrate upon reconstitution with the volume specified on the Certificate of Analysis (CoA). After creating Standard 1 following the table in the product insert, the Standard 1 value is the concentration listed on the CoA.
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At what frequency should Calibration and Verification tests be performed?
It is recommended that a Calibration test be performed within one week prior to running an assay. A Verification test should be performed prior to data acquisition on the day of running an assay.
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