Mouse IRF3 Alexa Fluor® 750-conjugated Antibody

Catalog #: AF4454S Datasheet

Catalog #	Availability	Size / Price	Qty
AF4454S-100UG

All IRF3 Antibodies

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Mouse IRF3 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse IRF3 in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant mouse IRF3 Thr201-Ile419 Accession # P70671

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied

Background: IRF3

IRF3 is a member of the interferon regulator transcription factor family. IRF3 is typically found inactive in the cytoplasm. IRF3 is activated by the toll like receptors (TLR3 and TLR4), as well as, viral entry. Upon activation and phosphorylation, IRF3 heterodimerizes with CREBBP, which translocates to the nucleus to stimulate transcription. IRF3 does not contain transactivation function on its own; it must either recruit or be part of a complex of transcription factors to stimulate gene transcription.

Long Name

Interferon Regulatory Factor 3

Entrez Gene IDs

3661 (Human); 54131 (Mouse)

Alternate Names

interferon regulatory factor 3; IRF3; IRF-3