Mouse HAI-2 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB1107T Datasheet

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FAB1107T-100UG

All HAI-2A Antibodies

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Mouse HAI-2 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects rmHAI-2 in direct ELISAs and Western blots. Less than 5% cross-reactivity was observed with rmHAI-1 and rhHAI-2.

Source

Monoclonal Rat IgG2a Clone # 170317

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse HAI-2B
aa 30-197 (del 37-93)

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: HAI-2A

Two alternatively spliced forms of HAI-2 are found in human tissues. HAI-2A, the full-length molecule and also known as placental bikunin, is a major form expressed in human tissues. HAI-2A consists of two Kunitz domains, and a C-terminal transmembrane domain. Both Kunitz domains can function as inhibitors independent of each other. In addition to HGF activator and trypsin, HAI-2A strongly inhibits plasmin, tissue and plasma kallikreins, and factor XIa.

Three alternatively spliced forms of HAI-2 have been found in mouse tissues. HAI-2A is a minor form expressed in mouse tissues. HAI-2B, with residues 37 through 93 spliced out and thus lack of the first Kunitz domain, is a major form in mouse tissues. HAI-2B is an effective inhibitor of both HGF activator and trypsin.

Long Name

HGF Activator Inhibitor Type 2A

Entrez Gene IDs

10653 (Human)

Alternate Names

HAI2A; HAI-2A; Placental Bikunin; SPINT2