Mouse ErbB2/Her2 Antibody Summary
Thr23-Thr653
Accession # P70424
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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ErbB2/Her2 in Mouse Intestine. ErbB2/Her2 was detected in perfusion fixed frozen sections of mouse intestine using Sheep Anti-Mouse ErbB2/Her2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5176) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to plasma membranes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ErbB2/Her2
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a 185 kDa type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The mouse ErbB2 extracellular domain (amino acids 23-653 of 1256) shares 85% and 94% aa identity with human and rat ErbB2 ECD, respectively. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 has no identified ligands, but heterodimerizes with ErbB1 (EGF R), ErbB3, or ErbB4 to form higher affinity signaling complexes. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2.
Product Datasheets
Citations for Mouse ErbB2/Her2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury
Authors: Ho BL, Goh Q, Nikolaou S et al.
FEBS Letters
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NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury
Authors: Ho BL, Goh Q, Nikolaou S et al.
FEBS Letters
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Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis
Authors: J Stupack, XP Xiong, LL Jiang, T Zhang, L Zhou, A Campos, B Ranscht, W Mobley, EB Pasquale, H Xu, TY Huang
J. Neurosci., 2020-06-29;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode
Authors: Raúl M. Luque, Alicia Villa-Osaba, Fernando L-López, Ana I. Pozo-Salas, Rafael Sánchez-Sánchez, Rosa Ortega-Salas et al.
Breast Cancer Research
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