Mouse CCR1 PE-conjugated Antibody Summary
Extracellular regions (aa 1-34, aa 92-107, aa 172-192, aa 265-281)
Accession # P51675
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR1 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse CCR1 PE-conjugated Monoclonal Antibody (Catalog # FAB5986P, filled histogram) or isotype control antibody (Catalog # IC013P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of CCR1 in L1.2 Mouse Cell Line Transfected with Mouse CCR1 and eGFP by Flow Cytometry. L1.2 mouse pro-B cell line transfected with mouse CCR1 and eGFP was stained with Rat Anti-Mouse CCR1 PE-conjugated Monoclonal Antibody (Catalog # FAB5986P). Quadrant markers were set based on control antibody staining (Catalog # IC013P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR1
CCR1 (C-C chemokine receptor 1; also MIP-1a receptor and CD191) is a 43 kDa member of the GPCR #1 family of transmembrane proteins. Mouse CCR1 is expressed on osteoclasts, IL-13+ T cells, neutrophils, bone marrow-derived mast cells, eosinophils, monocytes and vascular intimal smooth muscle cells. Multiple chemokines are reported to bind to CCR1. MIP-1a/CCL3 and RANTES/CCL5 are natural ligands, while CCL15, CCL9 and CCL23 are potent angonists after N-terminal processing. Mouse CCR1 is a 7-transmembrane protein that is 355 amino acids (aa) in length. It contains a 34 aa N-terminal extracellular domain plus a 50 aa C-terminal cytoplasmic tail. Over aa sequences 1-34, 92-107, 172-192 and 265-281 collectively, mouse CCR1 shares 76% and 89% aa identity with human and rat CCR1, respectively.
Product Datasheets
Citations for Mouse CCR1 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing
Authors: Alvaro Morales-Molina, Miguel Ángel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belén de Andrés, María-Luisa Gaspar et al.
Cancer Research Communications
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Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells
Authors: S Trittel, BJ Chambers, U Heise, CA Guzmán, P Riese
Sci Rep, 2019-11-08;9(1):16362.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced anti-viral therapeutic effects
Sci Rep, 2016-12-13;6(0):39071.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
J Leukoc Biol, 2015-06-05;98(3):395-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival
Authors: Michail S. Lionakis, Muthulekha Swamydas, Brett G. Fischer, Theo S. Plantinga, Melissa D. Johnson, Martin Jaeger et al.
Journal of Clinical Investigation
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Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis
Authors: Michail S. Lionakis, Brett G. Fischer, Jean K. Lim, Muthulekha Swamydas, Wuzhou Wan, Chyi-Chia Richard Lee et al.
PLoS Pathogens
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