Mouse Artemin Antibody Summary
Ala112-Gly224
Accession # Q9Z0L2
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Cell Proliferation Induced by Artemin and Neutralization by Mouse Artemin Antibody. Recombinant Mouse Artemin (Catalog # 1085-AR) stimulates proliferation in the SH‑SY5Y human neuroblastoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse Artemin (15 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse Artemin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1085). The ND50 is typically 0.1-0.3 µg/mL.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Artemin
Artemin is a member of the Glia Cell-Derived Neurotrophic factor (GDNF) family ligands, which include GDNF, Persephin, Artemin, and Neurturin. GDNF family ligands are distant members of the Transforming Growth Factor beta (TGF‑ beta ) superfamily (1‑4). Similar to other TGF‑ beta family proteins, Artemin is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. The carboxy-terminal domain of Artemin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active Artemin is a disulfide‑linked homodimer of the carboxy-terminal 113 amino acid residues. Mature mouse Artemin shares 88.5% amino acid sequence similarity with human Artemin. Mature Artemin also shares approximately 40% amino acid sequence identity with the other three members of the GDNF family ligands (5). Bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFR alpha 1‑GFR alpha 4) and a common signaling component, cRET (receptor tyrosine kinase) (5‑8). Artemin prefers to bind to GFR alpha 3 and activites the GFR alpha 3‑RET. However, in the presence of RET, it can bind to GFR alpha 1 as well (4, 5, 9). Artemin has been shown to promote the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. It may also play an important role in the development of sympathetic neurons and several organs (5, 10, 11).
- Lin, L-F.H. et al. (1993) Science 260:1130.
- Milbrandt, J. et al. (1998) Neuron 20:245.
- Kotzbauer, P.T. et al. (1996) Nature 384:467.
- Baloh, R.H. et al. (1998) Neuron 21:1291.
- Takahashi, M. (2001) Cytokine and Growth Factor Reviews 12:361.
- Baloh, R.H. et al. (1997) Neuron 18:793.
- Jing, S. et al. (1996) Cell 85:1113.
- Jing, S. et al. (1997) J Biol Chem 272:33111.
- Nishino, J. et al. (1999) Neuron 23:725.
- Enomoto, H. et al. (2001) Development 128:3963.
- Andres, R. et al. (2001) Development 128:3685.
Product Datasheets
Citations for Mouse Artemin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Gdnf, Neurturin and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute To Inflammatory Bone Pain
Authors: S Nencini, M Ringuet, DH Kim, C Greenhill, JJ Ivanusic
J. Neurosci., 2018-04-30;0(0):.
Species: Rat
Sample Types: In Vivo
Applications: Neutralization -
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
Cell, 2018-03-29;0(0):.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: In Vivo, Neutralization -
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin
Nat. Immunol., 2016-11-21;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
Nature, 2016-07-13;535(7612):440-3.
Species: Mouse
Sample Types: Whole Cells
Applications: Blocking -
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice.
Authors: Li J, Klein C, Liang C, Rauch R, Kawamura K, Hsueh AJ
FEBS Lett., 2009-07-04;583(15):2479-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold.
Authors: Elitt CM, McIlwrath SL, Lawson JJ, Malin SA, Molliver DC, Cornuet PK, Koerber HR, Davis BM, Albers KM
J. Neurosci., 2006-08-16;26(33):8578-87.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity
Authors: Yuzhu Hou, Hua L. Liang, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao et al.
Science Translational Medicine
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