Mouse Amphiregulin Antibody Summary
Ser94-Lys191
Accession # P31955
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Amphiregulin
Amphiregulin (AR), also known as Schwannoma-derived growth factor (SDGF), is a member of the epidermal growth factor (EGF) family of growth factors which includes, AR, EGF, transforming growth factor-a (TGF-a), heparin binding EGF-like growth factor (HB-EGF), betacellulin (BTC), epiregulin, and the neuregulins-1 through -4. All EGF family members are synthesized as type I transmembrane precursors and contain one or several EGF domains in their extracellular region. The bioactive form of the proteins is released by proteolytic cleavage. The ErbB family of receptors that includes ErbB1 - B4, mediates the biological activities of the EGF family ligands. AR was originally isolated from the conditioned media of PMA-treated MCF-7 human breast carcinoma cell line. AR mRNA expression can be detected in numerous carcinoma cell lines and in the epithelial cells of various human tissues including colon, stomach, breast, ovary and kidney. AR stimulates the proliferation of keratinocytes, mammary epithelial cells, fibroblasts, astrocytes and glial cells. AR is also a growth inhibitor for certain tumor cells. The gene for AR has been mapped to human chromosome 4q13-q21 and mouse chromosome 5. Human and mouse AR cDNA encode 252 and 248 amino acid residue type I membrane proteins, respectively. The two proteins share approximately 69% sequence identity. Mouse AR also shares 81% amino acid sequence homology with rat AR. Several secreted isoforms of AR that vary in length and/or glycosylation level can be found in cell conditioned media. The 98 amino acid residue recombinant AR has better receptor binding and biological activity than the C-terminal truncated forms of the protein.
- Thompson, S.A. et al. (1996) J. Biol. Chem. 271:17927.
- Sonoda, H. et al. (1992) Biochem. Biophys. Res. Commun. 185:103.
- Normanno, N. et al. (2001) Frontiers in Bioscience 6:685.
Product Datasheets
Citations for Mouse Amphiregulin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Investigating the impact of antibiotic-induced dysbiosis on protection from Clostridium difficile colitis by mouse colonic innate lymphoid cells
Authors: Uddin, MJ;Thompson, B;Leslie, JL;Fishman, C;Sol-Church, K;Kumar, P;Petri, WA;
mBio
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity
Authors: Sun, R;Zhao, H;Gao, DS;Ni, A;Li, H;Chen, L;Lu, X;Chen, K;Lu, B;
Science advances
Species: Mouse
Sample Types:
Applications: In Vivo -
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Authors: Alexandra Schnell, Linglin Huang, Meromit Singer, Anvita Singaraju, Rocky M. Barilla, Brianna M. L. Regan et al.
Cell
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Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis
Authors: JH Ko, HJ Kim, HJ Jeong, HJ Lee, JY Oh
Cell Rep, 2020-03-17;30(11):3806-3820.e6.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.
Authors: Monticelli L, Osborne L, Noti M, Tran S, Zaiss D, Artis D
Proc Natl Acad Sci U S A, 2015-08-04;112(34):10762-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Temporal expression of growth factors triggered by epiregulin regulates inflammation development.
Authors: Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M
J Immunol, 2015-01-02;194(3):1039-46.
Species: Mouse
Sample Types: In Vivo, Whole Tissue
Applications: IHC-P, Neutralization -
The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
Authors: Jaya Nautiyal, Jennifer H. Steel, Meritxell Rosell Mane, Olayiwola Oduwole, Ariel Poliandri, Xanthippi Alexi et al.
Development
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