Modafinil

Catalog #: 1811
1 Citation Datasheet

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Modafinil | CAS No. 68693-11-8 | Additional Adrenergic Receptor-related Compounds

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Description: Psychostimulant

Alternative Names: CRL 40476

Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Technical Data

M.Wt:

273.35

Formula:

C₁₅H₁₅NO₂S

Solubility:

Soluble to 75 mM in DMSO and to 10 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

68693-11-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers.
Ferraro et al.
Biol.Psychiatry, 1997;42:1181
Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro.
Madras et al.
J.Pharmacol.Exp.Ther., 2006;319:561
Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset.
Jenner et al.
Exp.Brain Res., 2000;133:178

Product Datasheets

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Citation for Modafinil

The citations listed below are publications that use Tocris products. Selected citations for Modafinil include:

1 Citation: Showing 1 - 1

Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.
Authors: Yu Et al.
Sleep 2019;42

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