MM 102
Chemical Name: 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
Purity: ≥95%
Biological Activity
MM 102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
Karatas et al.
J.Am.Chem.Soc., 2013;135:669
Product Datasheets
Citations for MM 102
The citations listed below are publications that use Tocris products. Selected citations for MM 102 include:
2 Citations: Showing 1 - 2
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Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a.
Authors: Ayumu Et al.
Kidney Int 2019;96:1162-1175
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Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization.
Authors: Ilona Et al.
Sci Adv 2019;5:eaaw9051
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