MLS 1547
Chemical Name: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
Purity: ≥98%
Biological Activity
MLS 1547 is a G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 DA receptor.
Free et al.
Mol.Pharmacol., 2014;86:96
Product Datasheets
Citations for MLS 1547
The citations listed below are publications that use Tocris products. Selected citations for MLS 1547 include:
2 Citations: Showing 1 - 2
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Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas.
Authors: Ting Et al.
Br J Pharmacol 2021;178:3570-3586
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New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling.
Authors: Stefan Et al.
Sci Rep 2021;11:8288
FAQs
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