ML 334
Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
Purity: ≥98%
Biological Activity
ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
Hu et al.
Bioorg.Med.Chem.Lett., 2013;23:3039 -
Oxidative stress in Alzheimer's disease: are we connecting the dots?
Rosini et al.
J.Med.Chem., 2014;57:2821
Product Datasheets
Citation for ML 334
The citations listed below are publications that use Tocris products. Selected citations for ML 334 include:
1 Citation: Showing 1 - 1
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A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.
Authors: Vladimir Et al.
Redox Biol 2021;48:102186
FAQs
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