ML 315 hydrochloride

Catalog #: 5700 Datasheet

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ML 315 hydrochloride | CAS No. 1440251-53-5 | Cdc2-like Kinase Inhibitors

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Description: Inhibitor of Clk and DYRK kinases

Chemical Name: 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 315 hydrochloride is a inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC₅₀ values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Technical Data

M.Wt:

410.68

Formula:

C₁₈H₁₃Cl₂N₃O₂.HCl

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1440251-53-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Coombs et al.
Bioorg.Med.Chem.Lett., 2013;23:3654

Product Datasheets

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