ML 281
Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
Purity: ≥98%
Biological Activity
ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells.
Weiwer et al.
ACS Med.Chem.Lett., 2012;3:1034
Product Datasheets
Citation for ML 281
The citations listed below are publications that use Tocris products. Selected citations for ML 281 include:
1 Citation: Showing 1 - 1
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Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
Authors: Christopher J Et al.
Cancer Res 2022;82:3375-3393
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