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ML 162

Catalog #: 7821 Datasheet
Catalog # Availability Size / Price Qty
7821/50
7821/10
ML 162 | CAS No. 1035072-16-2 | Glutathione Peroxidase 4/GPX4
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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis

Chemical Name: 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide

Purity: ≥98%

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Biological Activity

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Technical Data

M.Wt:
477.41
Formula:
C23H22Cl2N2O3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1035072-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
    Weïwer et al.
    Bioorg.Med.Chem.Lett., 2012;22:1822

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